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Biomedical subjects

A Janev

Publications and source records attributed to A Janev.

13 recordsLinked to original sources
PubMed1981

[Analysis of causes of CNS damages in neonates delivered by cesarean section (author's transl)].

Of 27.978 newborns delivered at the University Hospital Department of Gynecology and Obstetrics in Beogradu, from 1978 to 1980, 2218 (7.92%) were born by cesarean sections. Clinical-biochemical and morphological elements of hypoxic and ischemic CNS lesions were found in 107 (4.82%) cases out of the infants born by cesarean section and in 1301 (5.05%) cases out of the infants born by vaginal delivery. The difference is not statistically significant. Investigations of the causes, i. e. risk factors of CNS lesions in infants born by cesarean section, in correlation with the control group consisting of 670 cesarean sections performed in 1980 without CNS lesions, have revealed: a) high risk factor (p less than 0.01) appeared to involve parity (para III and more), maternal diseases (hypertension, diabetes mellitus, EPH gestosis), placenta praevia, premature rupture of the membranes, prematurity birth weight below 2500 g, and low Apgar score (1-7); b) significant risk factors (p less than 0.05) are some social factors (unemployed mothers and mothers from rural areas), duration of labor (more than 10 hours), transverse presentation, hydramnion, previous spontaneous abortions and stillbirths. The analysis has shown that CNS lesions in infants born by cesarean section may result from different factors; medical, biological, and social.

Central Nervous System Diseases↗
PubMedDate not supplied

[Morphological study of 2 cases of congenital toxoplasmosis].

A morphological study of two cases of acute generalized congenital toxoplasmosis has shown that in one case the most heavily involved organ was the heart (focal necrotic myocarditis), in addition to some changes in the central nervous system (leptomeningitis), and in the other case, the most affected organ was the cerebrum (focal necrotic encephalitis). In both cases, in almost all organs, there were degenerative and reactive changes. Toxoplasma was found in necrotic foci of the myocardium and the brain. Some basic views concerning a special vulnerability of the central nervous system in toxoplasmosis are put forward. The basic fact is that the explanation for the infection of exposed fetuses lies in the condition of the immune system (in the degree of its development and activity), especially regarding certain localizations of changes in the organs with a less developed activity of the local immune system.

Autopsy↗
PubMedDate not supplied

[Congenital anomalies of the uterus. (Pregnancy, delivery, and the newborn].

A total of 123 women with congenital anomalies of the uterus were analysed. It has been found that earlier pregnancies terminated with abortus in a high percentage (68.09%). In the course of the last pregnancy and the first in primiparas, 39.02% of women developed one or more complications. The delivery itself was completed by cesarean section in 75.6% of parturients. In the course of labour, complications appeared in 44.71% of women; most frequently there was a premature rupture of the bag of waters and the adhered placenta. The abnormal position of the fetus was found in 54.47%, it was mostly the pelvic presentation. A comparison between the perinatal mortality in earlier deliveries and the last one has shown that there is a significant association between the use of cesarean section and perinatal mortality. In earlier deliveries the perinatal mortality rate was 48.78% and in the last pregnancy 8%. There were 19.2% before-term babies. By Apgar score 1--8, 55.73% of newborns were assessed. The babies were often hypotrophic in relation to their gestation age. A high percentage of congenital anomalies in newborns (16.8%), mostly joint deformations, was established. It is concluded that uterine congenital anomalies exert an unfavourable effect on pregnancy. They put both mother and child at risk. The risk could be diminished by a timely detection of uterine anomalies, by the appropriate therapy, and by the use of cesarean section.

Adult↗