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Biomedical subjects

A Janni

Publications and source records attributed to A Janni.

At least 37 records · Page 2Linked to original sources
PubMed1991

Results of treatment and lessons learned from pathologically staged T4 non-small cell lung cancer.

Depending on the local extension of primary non-small cell lung cancer (NSCLC) and invaded T4 structure(s), 49 patients underwent complete (CR, n = 14) or palliative (PR, n = 13) resection of exploratory thoracotomy (ET, n = 22) between January 1982 and June 1988. Thoracic radiotherapy (TR) was given to all patients receiving PR (median dose, 43 Gy) and ET (median dose, 53 Gy). With a median follow-up of 44 months, overall 2- and 5-year survival was 25 and 5%, respectively. Patients undergoing ET plus TR had a significantly worse survival than those treated by CR (P = 0.041) and PR plus TR (P = 0.046). Only completely resected patients became long-term survivors (5-year survival, 29%) and significant predictors of their survival were previous weight loss, hemoglobin, and creatinine level, in univariate analysis, and previous weight loss in multivariate analysis. The site of initial treatment failure was mainly local for PR plus TR (85%) and systemic for CR (71%) and ET plus TR (86%). Presented results suggest that surgery might play a role for selected patients with T4 NSCLC, but advances in systemic and local therapy are necessary.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1991

Functional results of bronchial sleeve lobectomy.

The primary purpose of this study was to evaluate whether preservation of lung function parallels preservation of anatomy following elective bronchial sleeve-lobectomy (BSL). Between January 1984 and July 1988, 21 male patients (median age 51 years) with non-small cell lung cancer (n = 18), atypical carcinoid (n = 2) and inflammatory stenosis (n = 1) entered the study. Pulmonary function tests were performed pre- and postoperatively (at 3 and 12 months) and included spirometry, a quantitative perfusion lung scan and arterial blood gas analysis. The majority of operations were performed on the right lung (n = 15, 71%), with no operative deaths or major complications. Three months after surgery, the values of PaO2, PaCO2 and overall perfusion improved significantly (P less than 0.05), while there was a non significant improvement of the forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). The only parameter correlating (r = 0.46) and significantly (p = 0.032) predicting outcome after resection was overall perfusion. The preserved, reimplanted lobe rather than contralateral lobe(s) significantly (p = 0.014) contributed to remaining overall function. In 16 patients examined 12 months post-operatively a further improvement in pulmonary function occurred. The data presented demonstrate that preservation of pulmonary function parallels preservation of anatomy following BSL and that the functional contribution of reimplanted, ipsilateral lobe(s) is of paramount importance.

Carcinoma, Non-Small-Cell Lung↗
PubMed1988

Prevalence of late-onset 11 beta-hydroxylase deficiency in hirsute patients.

Serum levels of 11-deoxycortisol were determined in 182 hirsute women. Three patients presented high basal 11-deoxycortisol levels and an exaggerated response of this steroid to ACTH stimulation. A fourth patient had normal basal 11-deoxycortisol but was hyperresponsive to ACTH stimulation. Therefore diagnosis of late-onset 11 beta-hydroxylase deficiency was made in 4 out of 182 hirsute women with a prevalence of 2.2% in the group studied. In these patients, clinical findings and other hormonal patterns were not different from those of other women suffering from hirsutism.

Adolescent↗
PubMed1985

Surgical treatment of primary lung cancer and solitary brain metastasis.

Twenty patients with carcinoma of the lung and a brain metastasis have undergone combined lung and brain surgery, which was synchronous in five. There were no operative deaths. Survival from the first surgical intervention was less than one year (3-10 months) in four patients (20%), one to two years in four (20%) and more than two years (26-66 months) in five patients (25%). Seven patients (35%) are alive and well after an average period of three years and three months (15-66 months). Actuarial survival at five years is 33.6%. All patients had severe neurological symptoms and 18 (90%) had a complete remission. Our experience and data reported in the literature point to the effectiveness of combined lung and brain surgery in prolonging symptom free survival in patients with lung cancer and solitary brain metastasis.

Adult↗
PubMed1984

Results of en bloc resections for lung cancer.

The results of en bloc resection carried out in 33 patients with lung cancer involving the chest wall are described. Microscopic examination of the lung specimen revealed large cell anaplastic carcinoma in 14 cases, squamous carcinoma in 10, adenocarcinoma in 5, microcytoma and fibrosarcoma in 2 cases respectively. The 5 year survival, calculated according to the actuarial method, was 32%, only slightly lower than the 5 year overall survival observed in our survey. The long-term prognosis was essentially related to the presence of lymph node metastases, which were found to occur at a late stage of the clinical evolution.

Actuarial Analysis↗
PubMed1980

[Association of secondary short esophagus and adenocarcinoma of the esophagogastric junction].

The case of a 39-yr-old male with adenocarcinoma which arose on short oesophagus secondary to congenital hiatal hernia is reported. The patient was treated by oesophagogastric resection and intrathoracic anastomosis. After a short analysis of the literature, the infrequent incidence of hiatal hernia and the rarity of secondary short oesophagus are considered and the association in question is attributed to chance.

Adenocarcinoma↗
PubMed1976

Incomplete type I male pseudohermaphroditism.

The observation of a case of male pseudohermaphroiditism offered the opportunity for an analytical review of this pathology. Clinical features and failure to respond to prolonged testosterone treatment allowed this case to be included in the group characterized by androgen resistance of which a recent classification distinguishes various types on the basis of phenotypic and hormonal features. Incomplete virilization of the external genitals and high testosterone and LH plasma levels were evidence in favour of the conclusion that the case should be classified as incomplete male type I pseudohermaphroditism.

Adult↗
PubMedDate not supplied

Perfusion MRI in normal and abnormal pituitary gland. A preliminary study.

Perfusion MRI (magnetic resonance imaging) of the pituitary gland was performed in 20 healthy volunteers and 63 patients with various lesions involving the pituitary gland. All patients underwent sequential contrast-enhanced MRI using spoiled gradient recalled sequences with high temporal resolution (7 seconds). Four pituitary areas (pituitary stalk, posterior lobe, postero-superior, and antero-inferior adenohypophysis) were tested with a selected region of interest. Maximal contrast percentual variation was calculated. The timing of enhancement in normal patients matched perfectly with normal pituitary vascularization. Abnormal timing in pathological condition was investigated.

Adenoma↗