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Biomedical subjects

A Jmelnitzky

Publications and source records attributed to A Jmelnitzky.

24 records · Page 2Linked to original sources
PubMed1987

[Alcoholic hepatitis: epidemiologic nature and severity of the clinical course in Argentina].

Focusing on frequency and severity of alcoholic hepatitis (AH) in our country, data provided by 10 university and health care centers were analyzed, based on a form specially designed; 3428 autopsy protocols, 4315 laparoscopy and/or liver biopsy records, and 414 clinical histories from histopathologically proved AH patients, were selected as information source. Autopsy prevalence was 2.4%, corresponding to AH 7.7% of whole diagnostic liver biopsies, 24.6% of those taken from chronic alcoholics, and 32.2% of biopsied alcoholic liver diseases. Clinical severity was related to the kind of centre where data came from (hepatological, neuropsychiatric, etc.) but general sample showed 76.5% mild AH, 17.6% moderate, and 5.7% severe. Acute mortality attributable to AH was 5.5%, raising up 40.0% in severe type group; clinical severity seemed to be more related to mortality than co-existent cirrhosis. Spontaneous encephalopathy, prothrombin concentration under 50% without response to K vitamin supply, and hepato-renal syndrome, were the more significant bad prognosis factors (31.2%, 50.6% and 66.6% mortality respectively).

Adult↗
PubMed1983

[Algorithm in hepatology. Blind biopsy or laparoscopic biopsy?].

Data from 1035 laparoscopic examinations were evaluated with 1% general morbidity and 0.1% death rate - Comparative diagnostic sensibility, specificity and predictive value between endoscopic and histologic findings from 748 cases (408 diffusse - parenchimatous liver diseases, 246 focal - nodular lesions, and 94 normal liver) were calculated. General sensibility (s) was similar for both laparoscopy and histology (s = 93) with different behavior for diffusse liver disease (DLD) and focal-nodular disease (FND) as follows: DLD: Laparoscopy s = 90 +/- 3 Vs. Histology s = 100. FND: Laparoscopy s = 98 +/- 1.8 Vs. Histology s = 85 +/- 4.8 Laparoscopic specificity (Sp) for FND was high (Sp = 100), but 10.6% false positive was diagnosed as DLD (Sp = 90 +/- 6.5). Non histologic false positive were found. High positive predictive value (p.p.v.) was found all cases: DLD: Laparoscopy ppv = 0.97 Vs. Histology p.p.v. = 1. FND: Laparoscopy ppv = 1 Vs. Histology p p.p.v. = 1. On the other hand, negative predictive value (npv) evidences well diferentiated results: DLD Laparoscopy n.p.v. = 0.69 Vs. Histology n.p.v. = 1. FND Laparoscopy n.p.v. = 0.94 Vs. Histology n.p.v. = 0.68. Histologic findings can not replace high fiability of macroscopic ones for FND diagnosis; then, blind liver biopsy is not recommended for this cases, but it could be very useful for DLD diagnosis.

Adolescent↗
PubMed1982

[Epidemiological significance, clinico-morphological evaluation and behavior of pathogenetic factors, in asymptomatic chronic carriers of the HBsAg in the La Plata area. Study in voluntary blood donors].

Seric positivity for HBsAg (CIED) investigated on 100.000 volunteer blood donors of La Plata city was 0.239%. Humoral findings on 40 cases only revealed TGO-TGP seric levels over twice the normal in 15 and 10% respectively. On 27 biopsied patients, chronic active hepatitis in one case and chronic persistent hepatitis in another one were found. Non-specific chronic inflammatory changes were seen in 18.5%. Correlation between TGO-TGP levels and histologic damage was generally proved. HBeAg seric positivity in 3/29 cases (10.3%) was accompanied of both raised TGO-TGP levels and some kind of chronic inflammatory change. Statistic high risk was determined for both O-Rh negative blood group and HLA-Bw21 individuals. Diminished cutaneous PPD reactivity without significative alteration of linfocite population was established.

Adult↗
PubMed1979

[Endoscopic cytological diagnosis of the upper digestive tract].

207 cases of oesopha-gastric endoscopic exfoliative citology was realized during 1976-1977, 126 was malignant and 81 non-malignant. The high general diagnosis posivity in oesophagus (96,9% without erroneous posivity, and a posivity of 88,8% en stomach, with 4,2% erroneous posivity are remarked. The quick diagnosis, the easy technique and the unexpensive process, both the needed of high professional capacity, are realized. The incidence of tumoral localization, macroscopic and histologic characters on diagnosis security are comented.

Biopsy↗