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Biomedical subjects

A Job

Publications and source records attributed to A Job.

36 records · Page 2Linked to original sources
PubMed1997

Light and electron microscopic findings in rhinosporidiosis after dapsone therapy.

Morphological findings in serial nasal mucosal biopsies from three cases of rhinosporidiosis on dapsone therapy were compared with biopsies from 33 patients taken before dapsone or surgical treatment was initiated. All biopsies were examined by light microscopy and five by electron microscopy. Counts of histologically intact and degenerated organisms showed a decreasing proportion of intact forms with treatment.

Dapsone↗
PubMed1996

VISAUDIO: a Windows software application for Bekesy audiogram analysis and hearing research.

A Windows software system has been designed to facilitate hearing research programs and decision aid for epidemiological surveys in a military context. VISAUDIO provides graphical displays of audiograms with the results of various processing (smoothing, pathological patterns detection and classification), audiograms with pathological patterns like scotoms and recruitments are described (number, impaired frequencies, severity of loss for scotoms). Classical French ORL indexes are calculated (Index 42 which is the French legal index in occupational medicine, PAM or Lafon's index, IPA from the French norm NF S31-013 and IRB, a new occupational medicine index). An audiometric pattern classification is done for each audiogram using discriminant factorial analysis. The program allows audiogram comparisons on the same screen. The processing and analysis results can also be copied to any Windows software package via a PC clipboard. This prototype software is to be tested in a quasi real-time audiological information system comprising audiogram acquisition, processing, analysis and storage in a database. VISAUDIO software functions are illustrated with examples of screen displays.

Adult↗
PubMed1995

Use of digoxigenin-labeled RNA probe to test hepatitis A virus antiviral drugs.

A nucleic acid hybridization assay was used to evaluate inhibitory activity of antiviral compounds against hepatitis A virus (HAV) in cell culture and compared to radioimmunoassay by analysis of variance procedure. The 5' genomic end of the HM-175 strain was used as digoxigenin-labeled RNA probe. Dot-blot examination showed a reduction of detectable HAV RNA in infected cells when treated with amphotericin B. An antiviral dose-effect was shown by statistical analysis of densitometric measures of hybridization signals. Comparison between molecular hybridization assay and radioimmunoassay by analysis of variance procedure showed the equivalence of both methods. Data previously obtained on selected drugs by antigen and infectious titres determinations were confirmed by hybridization assay and make possible digoxigenin-labeled RNA probe use to measure an antiviral dose-effect for screening of hepatitis A antiviral compounds.

Amides↗
PubMed1994

A three-dimensional representation of an athletic female knee joint using magnetic resonance imaging.

Intense interest in knee joint mechanics has resulted in the development of numerous models to predict forces acting at the knee. However, few models have accounted for the unique geometric characteristics of the knee joint's articular surfaces when predicting the mechanical response of the joint. The purpose of this study was to stimulate accurately the complex geometric characteristics of the tibiofemoral joint for input into a finite element model representing the knee joint of athletic females. The right knee of an athletic female with no history of knee joint trauma was imaged using a 0.5 T magnetic resonance imaging (MRI) unit. Twelve cross-sectional slices of the knee were scanned in each of three orthogonal planes (coronal, sagittal and axial) at slice intervals of 6 mm, 7 m, and 8 mm respectively. A scan plan (two coronal images and an axial image) was also generated to enable calculation of the orthogonal scans with respect to one another. Select anatomical reference points representing cancellous and compact bone, major ligament attachment areas, and articular cartilage of the distal femur and proximal tibia were digitized from the processed shadowgraphs. The processed digitized data were input into a computer graphics program which was the pre- and post-processing software for the finite element analysis package. Contours of the cancellous and compact bone of the tibial and femoral condyles were generated using beta and cubic spline curves. Bezier quadratic and cubic polynomials were used to reconstruct the tibial and femoral shafts.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1993

Medical therapy of rhinosporidiosis with dapsone.

Clinical, histopathological and ultrastructural studies in three cases of rhinosporidiosis show complete remission of infection within one year of therapy with dapsone. Light and electron microscope studies confirmed arrest of the maturation of the spores and accentuated granulomatous response with fibrosis following dapsone therapy.

Administration, Oral↗
PubMed1993

[Evaluation of consumptions of alcoholic drinks during the National Service].

Using only ingested alcohol quantity, where individual erroneous values are counted and weigh a lot, alcohol consumption evaluation is biased. An original alcohol consumption evaluation is explained: ordinal factor analysis, and evaluation scales are described. This study shows several people groups, whose sensitivity about alcohol consumption safety varies greatly: from people whose alcohol consumption is low and have a bad picture of alcohol, to people whose consumption is high, have a good picture of alcohol, or think that their consumption is low or normal. In fact, for the last ones, alcohol consumption safety will never be effective.

Adolescent↗
PubMed1993

[Early effects of neutron-gamma or gamma irradiation on the group toxicity induced by (+) amphetamine in mice].

To better understand the mechanism of action of gamma and neutron radiation on the dopaminergic system, the influence of the two irradiation modalities on the group toxicity of (+) amphetamine was studied in mice. Neutron-gamma irradiation (3.6-4.95 Gy) leads to an early toxicity reduction, while gamma-exposure (7-12 Gy) induces an increase in toxicity. This suggests that these two types of radiation induce different early effects on central dopaminergic system. Possible mechanisms are discussed.

Actuarial Analysis↗
PubMed1993

[Detection of hepatitis A virus by riboprobe labeled with digoxigenin: comparison of methods].

A riboprobe (RNA probe), corresponding to the 5' end of the HM175 hepatitis A virus (HAV) genome, was synthetized in vitro and was digoxigenin-labeled. Then the riboprobe was used to detect the CF53 HAV strain. Conditions of virus denaturation (with or without SDS and proteinase K, timing of assay) to release viral RNA were tested by dot-blot hybridization on a ten fold dilution of HAV suspension. Densitometric measures of dot-blot spots allowed to appreciate optimization of the method. Sensitivity of hybridization was compared with sensitivity of radioimmunoassay (RIA) and cell culture methods. Hybridization signals and scale of HAV suspension were consistent when 0.05% SDS, 0.17 micrograms/ml Proteinase K, 37 degrees C, 30 mn or 3 hours are used. 8.10(2) TCID50 HAV was detected by hybridization with digoxigenin-labeled RNA probes. Detection threshold was the same as radioimmunoassay and lower comparatively to cell culture.

Densitometry↗
PubMed1993

[Computer analysis of audiograms in epidemiologic surveillance of cohorts exposed to excessive noise].

We have developed a method for the assessment of auditive loss using a sample of 1794 Bekesy audiograms recorded in young military students. A rectangular digital filter was used to smooth rough audiogram signals so as to detect pathological patterns such as scotoms and recruitments. Three factors were extracted from principal component analysis. They were correlated with the usual auditory indices and explained 70% of the total observed variance. The first factor is a general indicator of deafness, while the second and third describe the shapes of the hearing threshold level (asymmetry and convexity). This method can be used for rapid identification of suspect audiograms and is thus of value for epidemiological surveillance of populations exposed to impulsive noise.

Adolescent↗
PubMed1992

Medical management of pseudocyst of the auricle.

Four male patients with pseudocyst of the auricle were successfully treated with oral corticosteroids. This condition is an asymptomatic, non-inflammatory, cystic swelling, usually located in the scaphoid or triangular fossa of the anti-helix which if untreated, leads to deformity of the pinna. All successful methods of treatment described in the literature so far have been invasive. All four patients in the above series responded to oral steroid therapy alone.

Adult↗
PubMed1992

Laryngeal stridor in myasthenia gravis.

Two patients with laryngeal stridor secondary to myasthenia gravis are reported. The cause of bilateral abductor weakness in myasthenia is discussed; anticipation of the stridor in myasthenic patients is highlighted.

Adult↗
PubMed1988

Reactional states in the nasal mucosa: a clinical and histopathological study.

Twenty leprosy patients in the reactive phase of the disease were studied clinically and histologically for evidence of reactive lesions in the nasal mucosa. Ten of 14 patients with erythema nodosum leprosum (ENL) showed characteristic polymorphonuclear leukocytic infiltration and two patients showed vasculitis. The histological changes of reversal reactions in the nasal mucosa, one with upgrading reaction and the other with downgrading reaction, are reported.

Adult↗