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A Jobert

Publications and source records attributed to A Jobert.

60 records · Page 4Linked to original sources
PubMed1980

Conditioned suppression of behavior: its reversal by intra raphe microinjection of chlordiazepoxide and GABA.

Chlordiazepoxide and GABA (5 X 10(-5) M; 0.2 microliters) applied into the nucleus raphe dorsalis significantly reduced behavioral suppression induced in rats by a 10-min presentation of a signal previously associated with the punishment of lever pressing for food. As compared to saline control rats, this reduction was of the same order of magnitude as that obtained after intraperitoneal administration of chlordiazepoxide (8 mg X kg-1). Chlordiazepoxide or GABA (5 X 10(-5) M) failed to alter response maintained under non-aversive conditions. These data suggest the involvement of GABAergic neurons of the raphe dorsalis in the 'disinhibitory' effects of benzodiazepines.

Animals↗
PubMed1979

[Effects of muscimol and diazepam: a comparative study on behavioral inhibiton induced by novelty, punishment, and nonreward (author's transl)].

Diazepam and muscimol, a direct GABA agonist, were compared on behavioral inhibition induced in rats by (1) novelty, (2) punishment, and (3) nonreward. (1) Muscimol (0.03--0.25 mg . kg-1 i.p. 30 min before testing, or i.v. immediately before testing) failed to enhance food intake consistently in a nonfamiliar situation and (0.125--0.5 mg . kg-1 i.p. or i.v.) to increase the ingestion of an unknown food (chocolate); (2) muscimol (0.125--0.5 mg . kg-1 i.p. or 0.25 i.v. 10 min before testing) was ineffective in reducing the inhibition of lever presses for food elicited by the delivery of an electric shock at every eighth press; (3) muscimol (0.125--0.5 mg . kg-1 i.p.) failed to attenuate the inhibitory effects on responding induced by the suppression of the reinforcement during extinction. Contrastingly, diazepam (2 mg . kg-1 i.p. 30 min before testing) was found to reduce each type of behavioral inhibition. These data lend no support to the hypotheses of GABA control of behavioral inhibition and of GABA involvement in the action of benzodiazepines on inhibition induced by novelty, punishment, or nonreward.

Animals↗
PubMed1978

Picrotoxin-diazepam interaction in a behavioural schedule of differential reinforcement of low rates.

In rats working in a behavioural schedule of differential reinforcement of low rates (6 or 10 sec), picrotoxin (1 mg kg-1) decreased the number of premature responses and increased (in DRL 10 sec only) the number of rewarded responses. The effect of picrotoxin was antagonized by diazepam (2 mg kg-1). In contrast to picrotoxin, strychnine (1.5 mg kg-1) increased the number of premature responses.

Animals↗