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Biomedical subjects

A Jori

Publications and source records attributed to A Jori.

At least 19 recordsLinked to original sources

[The doctor and his relationship with patients in Greece in the fifth and fourth centuries B.C].

Ever since the fifth century B.C. Greek doctors were well aware of the importance and implications of the doctor/patient relationship. In the fifth and fourth centuries B.C. two contrasting views developed. The first is set out in various treatises of the corpus Hippocraticum, especially in those in which the genuine hippocratic spirit seems to be present, with significant echoes in Platonic thought. According to this, the doctor should carry on a continuous informative and persuasive dialogue with the patient. Under the alternative view, which is explained most clearly in another treatise of the Corpus entitled The Art, the medical practitioner, as the only person possessing scientific knowledge, acts only to convey instructions to ill people, without trying in any way to instal an exchange of information with them. This second model of the doctor/patient relationship has undoubtedly dominated throughout the history of western medicine, until this century in fact. Only recently has the need to involve the patient more directly in treatment been realised, as part of a humanistic approach to medicine.

Greece, Ancient↗

[Intelligent man and medicine].

In this article, three definitions of the ideal of the pepaideumenos (learned man) are examined in their mutual relations. In the pseudo-Platonic dialogue Amatores, the culture of the pepaideumenos is conceived as exhaustive as regards content, whereas it is attributed a merely 'formal' character in Plato's Charmides. However, on the theoretical level both solutions appear to be unsatisfactory. Aristotle's proposal is more convincing. He considers the pepaideumenos as the man who is able to assess the technicians' preparation adequately, since he knows the endoxa either with reference to knowledge as a whole or to individual technai. In all three cases, the example of the iatrikê (medicine) is the means to test the validity of the proposed resolutions.

Attitude to Health↗

Ecotoxicological profile of xylenes. Working Party on Ecotoxicological Profiles of Chemicals.

The xylenes (o, m, p), which are produced in large amounts and widely used, must be considered as environmental contaminants, as they have been identified in the atmosphere of many countries. Their acute and chronic toxicity in mammals is moderate. Mutagenic and teratogenic properties can be excluded. Carcinogenic potential has been at present inadequately studied. In man some disturbances are evident at the concentration of 45 ppm. Hepatic metabolism is a valid process of detoxification and its high rate limits the risk of accumulation of the xylenes in adipose tissue. Ecotoxicological data refer almost exclusively to water. No long-term tests have been made. However, the high volatility, elevated elimination, and the low factor of accumulation suggest the impact on aquatic environment should be limited. Xylenes are easily biodegraded by many microorganisms. Photoxydation is one of the main degradation processes, responsible for the disappearance of the xylenes from the atmosphere.

Animals↗

Distribution and localization of p-hydroxy-d-amphetamine in rat brain.

p-Hydroxy-d-amphetamine (p-OHdA) penetrates the blood--brain barrier poorly, when given acutely or by repeated systemic treatments, or when formed by biotransformation from administered d-amphetamine. However its distribution is relatively selective as it accumulates in the striatum more than in the brainstem. The rate of disappearance also differs in the two areas, being slower in the striatum than in the brainstem. These findings suggest that p-OHdA might be stored in different compartments. To check whether p-OHdA specificially accumulated in nerve terminals, catecholaminergic nerve endings were destroyed with 6-hydroxydopamine (6-OHDA). It has been shown that p-HOdA accumulates much less in the striatum of 6-OHDA-treated rats than of controls. This effect was not present in the brainstem. Accumulation of p-OHdA was similar after repeated d-amphetamine administration. The results are interpreted as showing that p-OHdA tends to accumulate in dopaminergic structures.

Amphetamines↗

A genetic analysis of the hyperthermic response to d-amphetamine in two inbred strains of mice.

A genetic analysis of amphetamine-induced hyperthermia was conducted in inbred mice of the strains Balb/c and C3H and in their F1F2 and backcross generations. The results of biometric analysis indicate that the effect of amphetamine on body temperature is genetically determined. The mode of inheritance characterized by a partial dominance (Balb/C over C3H strain). However, a possible maternal effect of C3H can overcome the dominant effect in male progenies and inhibit amphetamine hyperthermic effect.

Animals↗

Stereoselective disposition of fenfluramine enantiomers in the rat.

1. Rats were treated with d-, l-or dl-fenfluramine. The two optical isomers and their metabolites were determined in plasma, red blood cells and brain areas such as striatum and brainstem. 2. In all cases, the levels of d-fenfluramine were higher than those of the l-enantiomer, while levels of the metabolite norfenfluramine were lower for the d- than the l-form. 3. When metabolism of fenfluramine was inhibited by pre-treatment with SKF 525-A, the concentrations of the enantiomers no longer differed.

Animals↗

Differences in the availability of d- and l-enantiomers after administration of racemic amphetamine to rats.

1. Rats were treated with racemic amphetamine or separately with the single enantiomers. The two optical isomers were determined in several brain areas, in plasma and urine. 2. The concentration of d-enantiomer significantly exceeds that of the l-enantiomer in brain and plasma but not in urine, following administration of racemic amphetamine. In contrast, when the two isomers are given separately, their brain concentrations are similar. 3. Such a difference does not appear in the brain of mice treated with racemic amphetamine or in the brain of rats pre-treated with SKF 525-A, an inhibitor of amphetamine hydroxylation. 4. The possibility that the l-isomer can interfere with hydroxylation of d-amphetamine is discussed.

Amphetamine↗