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Biomedical subjects

A Jovanovic

Publications and source records attributed to A Jovanovic.

47 records · Page 3Linked to original sources
PubMed1993

Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas.

This study examined p53 expression immunocytochemically in 40 lingual squamous cell carcinomas from Dutch patients with known histories of smoking and/or drinking alcohol. 30% of neoplasms showed positive p53 reactivity, suggesting increased levels of p53 protein. No alcohol or tobacco risk factors were evident in 33.3% (4/12) of p53-positive neoplasms whereas only 7.1% (2/28) of p53-negative neoplasms showed an absence of these risk factors. 25% (3/12) of p53-positive neoplasms and 71.4% (20/28) of p53-negative neoplasms were found in patients who had been exposed to both alcohol and tobacco. A similar negative association with p53 reactivity was also found when either tobacco or alcohol were used in isolation. The results contrast with previous observations in head/neck and oral carcinomas and indicate that the association of alcohol/tobacco and p53 expression remains open to question.

Alcohol Drinking↗
PubMed1993

Squamous cell carcinoma of the lip and oral cavity in The Netherlands; an epidemiological study of 740 patients.

The epidemiological data of 740 patients with primary squamous cell carcinoma (SCC) of the lips or oral cavity is reported. The mean age was 63 years. The mean onset of oral cancer in women was 7 years later than in men. Patients under the age of 40 years were mainly males. The male-to-female ratio ranged from 8.3 for the lower lip to 0.9 for the upper alveolar ridge with an overall ratio of 1.8. In the case of multiple oral SCCs the tongue was the most frequently affected site. No significant association was found between the age or gender of patients and the size of the tumour. However, a significant association was observed between the site and size of the tumour. Lesions of the lower lip had a significantly smaller size than tumours of other sites. Furthermore, a linear trend could be observed between the size of the tumour and the clinical stage of the neck.

Adult↗
PubMed1993

Tobacco and alcohol related to the anatomical site of oral squamous cell carcinoma.

The aim of the present study was to evaluate the possible relationship between tobacco smoking and alcohol drinking and the anatomical sites of squamous cell carcinoma (SCC) of the lip and oral cavity. For this purpose, a case-case study has been performed in 690 patients. The study was focused on the relative risk (RR) or developing SCC at various (sub)sites, for smokers and drinkers of alcohol (divided into moderate and heavy users) relative to non-smokers and non-drinkers. Estimates of ratios of these relative risks were obtained. The relative risk associated with tobacco smoking, adjusted for the use of alcohol, appeared to be highest for SCC in the retromolar area, followed by the floor of mouth, whereas the lowest RR was found in the cheek mucosa. For alcohol drinking, adjusted for tobacco smoking, RR of SCC of the floor of mouth was significantly higher than for the tongue, whereas the RR of SCC of the cheek appeared to be lowest. Furthermore, this study suggests that the contrasts between relative risks, observed by anatomical site of oral SCC, are more pronounced for tobacco smoking than for the use of alcohol. The possible local and systemic factors responsible for these variations of susceptibility for tobacco and alcohol within the oral cavity are discussed.

Aged↗
PubMed1992

Delay in diagnosis of oral squamous cell carcinoma; a report from The Netherlands.

The referral pattern, patients' and doctors' delay of a limited number of 50 patients suffering from oral squamous cell carcinoma have been investigated. The majority of the patients consulted the family doctor as the first source of help. The mean patients' and doctors' delay was 103 and 22 days, respectively the median being 35 and 11 days, respectively. The gender, dental status, site and tumour size did not show a significant correlation with the delay. Measures directed to the early detection of oral cancer should place special emphasis on the patients' delay.

Attitude to Health↗
PubMed1992

Referral pattern of patients with oral mucosal lesions in The Netherlands.

The referral pattern of 140 Dutch patients with oral mucosal lesions, who had been referred to a Department of Oral & Maxillofacial Surgery and Oral Pathology, shows that patients with oral mucosal lesions consult the dentist as often as the family doctor as the first source of help or information. Furthermore, family doctors were much more used to refer patients with oral mucosal disease to medical specialists rather than to the dentist or the oral and maxillofacial surgeon.

Adolescent↗
PubMed1989

[Prevalence study of oral mucosal lesions in 300 patients].

Intraoral examination was performed in 300 consecutive patients, who attended the Department of Oral and Maxillofacial Surgery of the Free University Hospital, Amsterdam. In 89% of the patients one or more oral mucosal lesions were observed. Fordyce's spots, coated tongue, leukoedema, melanin pigmentation, frictional keratosis, and morsicatio buccarum were the most frequent occurring lesions.

Dental Health Surveys↗
PubMed1987

ST 567 (alinidine) in stable angina: a comparison with metoprolol.

Alinidine, a drug which reduces heart rate without depressing myocardial function was compared against metoprolol, a beta-blocking drug, in the treatment of stable angina pectoris in a double-blind cross-over trial. It was found that both drugs reduced anginal attacks and nitroglycerine consumption to a comparable degree. Exercise tolerance did not appear to be improved by either drug yet chest pain at ergometry was postponed by both drugs. In the doses used metoprolol was more effective in restraining heart rate, both at rest and even more during exertion. Both drugs were well tolerated and side-effects were few. It seems probable that the optimal dose of alinidine was not used in this trial and that the dosage could have been higher.

Angina Pectoris↗
PubMed1984

Flecainide: one-year efficacy in patients with chronic ventricular arrhythmias.

During a one-week short-term in-hospital period, 60 patients with chronic ventricular arrhythmias were treated with 200 mg flecainide twice a day. Flecainide reduced premature ventricular complexes (PVCs) by more than 85% without causing important side-effects in 47 patients, who entered a one-year follow-up period and were followed with bimonthly 24-h ECGs. Median PVC-frequency remained reduced by more than 99% during the follow-up period. Repetitive ventricular beats and ventricular tachycardia were present in 83% and 42% of patients, respectively, before flecainide. During follow-up, these arrhythmias were seen in less than 32% and less than 10% of patients, respectively, at each 24-h ECG. Furthermore, the mean number of hours with repetitive ventricular beats and ventricular tachycardia remained reduced by more than 76% and more than 79%, respectively, throughout the follow-up period. Ventricular arrhythmias remained suppressed despite a gradual reduction in flecainide dosages (to a median of 300 mg day-1) and flecainide plasma levels. In nine out of 47 patients, an increase in ventricular arrhythmias above baseline values on one or more occasions was observed. During a flecainide withdrawal period, a 65-fold increase in median PVC-frequency was observed and ventricular tachycardia reappeared in 18 patients. Subjective side-effects were acceptable except for two patients. During the follow-up period, one patient developed reversible heart failure and sinus node dysfunction. During the total study period, four patients, with either severe coronary artery disease (2) or cardiomyopathy (2) developed lethal arrhythmias (3) or ischaemic events (1). We conclude that prolonged flecainide treatment is effective in a high proportion of patients with chronic ventricular arrhythmias. In some patients an arrhythmogenic effect may occur.

Adult↗