This is a report of a patient with Hodgkin's disease who underwent a staging splenectomy and extensive radiation therapy and then developed "idiopathic" thrombocytopenic purpura. This appears to be the second known instance of such a combination of events. The patient was in complete remission of his Hodgkin's disease from radiation therapy at the time and continues in remission 56 mo since completing therapy. There was a complete and, apparently, permanent response of the thrombocytopenic purpura to a course of corticosteroid therapy.

Adult↗

PubMed1976

Toxicity of adenine arabinoside in humans.

Six forms of reversible adverse reactions to adenine arabinoside (vidarabine) were observed in a two-year period among 42 patients (19 of whom had lymphomas, leukemias, or other malignancies) who were treated for complicated infections with varicella-zoster or herpes simplex virus. Six patients received placebo. Ten patients received 10 mg of adenine arabinoside/kg per day; three received 15 mg/kg; 22 received 20 mg/kg; and one received 30 mg/kg. Patients were treated (by continuous intravenous injection) for an average of seven days. Toxic effects were nausea and vomiting, weight loss, weakness (often with impaired ambulation), megaloblastosis in erythroid series in bone marrow, tremors five to seven days after the start of therapy (including tremors in one patient with abnormal electroencephalograms that were consistent with toxic-metabolic encephalopathy), and thrombophlebitis at the intravenous site. Side effects clearly predominated in patients who received 20 mg/kg per day. Therefore, treatment with 10 mg/kg per day appears preferable until the relation of toxicity to dosage level can be clarified.

Anorexia↗

PubMedDate not supplied

[Heparin-induced thrombopenia].

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Aged↗