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Biomedical subjects

A K Angelov

Publications and source records attributed to A K Angelov.

13 recordsLinked to original sources
PubMed1987

[Clinical and morphological changes in the hoof sole of large ruminants with inflammatory diseases].

Clinical, morphological, and histomorphological investigations were carried out of the changes taking place in the solar matrix in some more common diseases in cows raised in the conditions on the enlarged farms of industrial cattle breeding. With the traumatic aseptic inflammations of the solar matrix the nova and its effect predetermine histologically the various degrees of changes, consisting in circulation disturbances, oedema of the connective tissue, disintegration of the connective tissue bundles, divergence of the collagen fibres, mucinous dystrophy, fibrinoid-necrotic foci, and heterophilic infiltration around the blood vessels and in their wall (arteriitis and periarteriitis). In suppurative inflammations of the solar matrix the process assumes diffuse character with strongly manifested leukocytic infiltration, with the development of dystrophic necrobiotic processes. As a result of these partially or more widely expressed separation (exungulatio) of the solar horn tissue from the matrix sets in. In the initial stage of the traumatic sole ulcer are observed the signs described for an aseptic inflammation. Later on the processes assume a more strongly manifested course, involving the matrix with atrophy and necrosis, separation of the hoof horn from the matrix. With the secondary complication with pathogenic organisms the signs of purulent and necrotic inflammation are seen, resulting in an ulcus defect.

Animals↗
PubMed1986

[Enterotoxemia in newborn calves due to Cl. perfringens types A, C and D].

The clinical symptoms and the morphologic picture of calf enterotoxemia are described. Studied were a total of thirty-two dead and slaughtered animals. Bacteriologically, the disease was shown to be caused by types A, D, and C of Clostridium perfringens. Types C and D proved pathogenic for guinea pigs, while type A did not. Isolated was a strain of Clostridium perfringens, which had high toxigenicity. It was found that calves were fairly often affected with the disease. Most severe were the infections caused by type C of Cl. perfringens, with most pronounced morphologic lesions. There were differences in the changes caused by all three types of the organism in calves, which made it possible to distinguish them as causative agents. Type A induced slight icterus and slightly manifested hemosiderosis of the liver, kidneys, and spleen; type D was responsible for severe injury and hyalin dystrophy of the kidneys; and type C caused necrotic enteritis, pronounced hemorrhagic diathesis, degenerative changes in the ganglial cells, and demyelinization of the brain.

Animals↗
PubMed1986

[Pathomorphological changes in experimental Erysipelothrix infection in lambs].

Investigations were carried out with eight lambs treated i/v with a broth culture of Erysipelothrix rhusiopathiae at the rate of 10(8) microbial cells per 1 cm3. Following infection the lambs developed polyarthritis. Studied were the morphologic changes in both dead and slaughtered lambs at various intervals after the infection was performed. It was found that from the 2nd up to the 7th day the lesions were characterized by moderate infiltration (neutrophil granulocytes) of the parenchymal organs as well as by dystrophic- and necrotic foci in the liver and hyperemia, edema, and hemorrhages in the spleen, lung, and brain. After the 7th day were found reticulohistiocytic proliferations in the liver and heart, and intracapillary glomerulonephritis, thromboendocarditis, and polyarthritis.

Animals↗
PubMed1986

[Clinical picture and pathomorphology of acute coenuriasis in sheep].

Clinical and morphological investigations were carried out in the case of two enzootics of coenurosis in weaned lambs. The disease was established in two flocks of 180 and 160 animals, respectively. Outbreaks were recorded two weeks after they were put on premises where dogs untreated for worms had been kept. Instable gait and incoordinated movements of the head and limbs were observed along with circling movements of the body, loss of herd instinct, and lay ill for a long time. Morphologically, hyperemia was seen in the meninges, hemispheres, cerebellum, and the basal portions of the brain, with swelling of the tissue, numerous oncospheres, and purulent and necrotic foci. Histopathologically, there were in the acute stages great numbers of parasite passages with detritus mass, hemorrhages, purulent-and-necrotic meningoencephalitis, and higher counts of neutrophile and eosinophile granulocytes. Besides, in the subacute cases there were histiocytes and lymphoid and gigantic alien cells. Differential diagnosis should take into consideration listeriosis, cerebrocortical necrosis, estrosis monesiosis, and enterotoxemia.

Acute Disease↗
PubMed1984

[Enzymatic and morphological study of the liver in acute radiation sickness].

The morphologic changes in the liver were investigated along with those in the activity of the specific liver enzymes in the blood plasma of rats in the case of the severe form of acute radiation disease. The rats were treated with 670 Rad at the rate of 90 Rad/min. The studies were carried out on the 1st, 8th , 15th, 22nd, and 30th day following irradiation. It was found that under the conditions of the experiment the activity of the cytoplasmic enzymes sorbitoldehydrogenase , cholinesterase, and leucinaminopeptidase strongly rose on the 1st day after treatment (the activity of sorbitoldehydrogenase increased 11 times). The activity of acid phosphatase and glutamate dehydrogenase also increased strongly, whereupon there was deterioration of the mitochondrial and lysosomal structures. Seen were well expressed processes of fatty and parenchymal dystrophy. The studies on the changes in the activity of these enzymes can be used as an adjunct, resp., an auxiliary test to the haematologic indices in the evaluation of the severity of radiation disease.

Acid Phosphatase↗
PubMed1984

[Morphological changes in the oviducts of infertile cows of the zebu breed].

Gross and histologic studies were carried out with a total of 118 Fallopian tubes of 59 slaughtered sterile cows of the Zebu breed originating from the Gamagüey region in Cuba. Morphologically, there were changes in 53 of the animals (89.8 per cent); of these in 29 cases both oviducts were affected, and in 24 of them only one was with lesions. In 6 of the cases (5 per cent) there were signs of acute salpingitis--hyperaemia, serous exudate, infiltration with lymphocytes and neutrophile granulocytes, and desquamation of the epithelium paving the folds. In 15 cases (13 per cent) there was subacute salpingitis--desquamation of the fold epithelium, negligible hyperaemia with oedema of the mucous membrane, and numerous plasmatic cells, fibroblasts, lymphocytes, and neutrophile granulocytes. In 61 cases (51 per cent) there were chronic salpingitis with varying fibrosis, atrophy of the folds, and cysts in the base of the folds. There were also sporadic cases of perisalpingitis.

Animals↗
PubMed1983

[Morphological changes in the placenta and in fetuses in cows with hypovitaminosis A].

Studied were morphologically 12 aborted fetuses of cows, 12 placentas of cows that miscarried, 6 placentas of cows with normal birth but with certain lesions, and 6 uteri of cows that miscarried, originating from various regions of the country. No organisms were found in both the placentas and fetuses. Carotenes in cows that miscarried gave the following values: 0.123 mg%, 0.287 mg%, 0.342 mg%, 0.684 mg%, 0.160 mg%, 0.168 mg%, 0.231 mg%, 0.430 mg%, and 0.484 mg%. Six grams of liver tissue of one of the slaughtered cows contained as many as 36 UI of vita. A. Gross investigations of the placentas revealed gray-whitish to gray-yellowish, round or oblong bulgings of 1-2 cm length. Histologically, hyperplasia and metaplasia of the surface epithelium were established, which from a monolayer one changed through metaplasia into a multilayer, flat, and cornificating one. In the lung, tongue, intestines, and vesical bladder of the fetus as well as in the endometrium of the cows that miscarried there were hyperplasia and metaplasia of the epithelium.

Abortion, Veterinary↗
PubMed1983

[Tumors of the ovaries in zebus].

In a total of 112 slaughtered sterile cows of the Zebu cattle, originating from the Camaguey region, Cuba, 25 tumors were found in 22 animals (in three of the cows the tumors were bilateral). Histologically, the tumors were differentiated as follows: 1 papillary adenoma, 6 papillary cystadenomas, 1 adenocarcinoma, 1 papillary adenocarcinoma, 8 granulosocellular tumors, 1 thecoma, 2 luteomas, 4 hemangiomas, and 1 angiocarcinoma. In two of the cases, beside tumors there were in the ovaries parovarian cysts. The differentiation of the tumors were made on the basis of the international histologic classification of tumors of the World Health Organization. Most frequently, the tumors turned out to be granulosocellular ones as well as papillary cystadenomas and hemangiomas.

Animals↗
PubMed1979

[Chronic progressive interstitial pneumonia in sheep (adenovirus pneumonia)].

Adenoviral infection was established in imported specialized meat strains of sheep Ile de France and Romni marsh. The disease followed a course typical of chronic interstitial progressive pneumonia with reduced tonus, loss of body weight, and high lethality. The disease was serologically proven by the discovery of specific complement binding antibodies in dynamics against the adenovirus. Titers varied from 1 : 2 to 1 : 32. The infestation was reproduced on sheep and lambs by tracheal infection with ultrafiltrate of changed lung tissue and bronchial lymph nodes. Morphologically the infection manifests itself by considerable hypeplastic processes in the lungs and less pronounced ones in the liver and kidneys. The typical changes indicated are accumulation of lymphoid cells and histocytes in the interstitial tissue, as well as adenomatous expansion of alveolar and bronchial epithelium. Considerable cell polymorphism is observed in the alveoles along with presence of gigantic cells and cell syncytia of desquamous epithelial cells, alveolar macrophages and intranuclear inclusions in some of these cells. Complications of Past. Haemolytica with developing catharalsuppurative pneumonia were observed in some cases.

Adenoviridae Infections↗
PubMed1979

[Toxicological studies of the technical phosphate of Pharmachem tylosin].

Studies on the acute, subchronic and chronic toxicity of technical tylosine phosphate (TTP) with 50 UI/mg activity, produced by Pharmachim were carried out. It was established that TTP does not cause lethality in white rats following application of 20, in white mice--of 40, in chickens--of 30 and in pigs--of 2 g/kg body weight. Long term application to the rations--of chickens for 40 days, in doses of 20, 40 and 60 g/kg fodder (=1.3 and 5 ED100) and of pigs for 32 days in doses of 2.6 and 10 g/kg fodder (=1.3 and 5 ED100) stimulates gain in weight of both species by 2-11.5% and improves the utilization of nutrition by 4.5-12.5% without any unfavourable effect on the clinical-biochemical composition of the blood and the structure and development of inner organs.

Animals↗
PubMed1978

[Morphological changes in the liver of gamma-irradiated chick embryos and chickens].

The morphologic changes produced in the liver through irradiation at the rate of 1000 rad are characterized chiefly by a well expressed fatty dystrophia. At many sites there are pycnotic and lysed nuclei of the parenchymal cells. In the embryonic liver these changes are most strongly manifested in 12-day-old embryos. In contrast to the irradiated adult birds the embryonic liver presents no processes on necrosis after radiation treatment.

Animals↗
PubMed1978

[Toxicity studies of Pharmachem's tylosin tartrate for broilers and turkeys].

Studied were the acute, subchronic, and chronic toxicity of the Pharmachim tylosin tartrate as well as the tolerance of chicken broilers and turkeys. The mean lethal dose of the antibiotic at subcutaneous application to 28-32 day-old broilers was 620 mg/kg; the oral dose was 1500 mg/kg. In the case of 42-45-day-old broilers these values were 740 and 5400 mg/kg. The LD50 at i/v infusion for 75-77-day-old ones was 48 mg/kg. Beside the age and route of introduction toxicity was found to depend on the initial biologic activity of tylosin tartrate. The subcutaneous injection of tylosin tartrate at the rate of 30 mg/kg for 20 days did not lead to changes in the appetite, behaviour, growth, and structure of viscera. A 42-day treatment at the same rate, however, resulted in slightly manifested and fully reversible dystrophic changes in the liver and kidneys. Higher doses (90 and 150 mg/kg) led to transient depression, stunting of growth, and a rise of the urea level and the activity of blood transaminases as well as to moderate destructive changes in the liver and kidneys. The stimulation of growth and the improvement of feed conversion (without deviations in the clinical and biochemical indices of the blood and the structure and development of the viscera in broilers) were recorded after the application of a water-soluble formula of tylosin tartrate for a period of 98 days offered via the drinking water in amounts equal to or exceeding 2 to 4 times the ED50. Turkeys' tolerance for the preparation was evaluated as very good so far as single i/m injective applications were concerned in doses exceeding 3, 5, and 10 times the average effective rates, no differences in this respect being noted with the comparative use of tylosin tartrate produced by the Elanco firm.

Animals↗