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Biomedical subjects

A K Bekbolotova

Publications and source records attributed to A K Bekbolotova.

16 recordsLinked to original sources
PubMed1999

[Changes in hypoxic resistance and conditional avoidance reflex during hypobaric adaptation on the "flatland" and in mountains].

White rats--males with mass 200-250 g were exposed ipobaroadaptation (rise on 12,000 m with an exposition 5 minutes) with periodic testing them on gipocsition stability. After shaping in the result of gipobaroadaptation stressostability, that it was judged in 2-3 times enlarging of reserve time, rats produced conditional reflexes at active avoid (CRAA) as on plain area (760 m) so in high-mountainous (2500 m). It is observed that gipobaroadaptation increases gipocsition stability and accelerates the CRAA shaping on plain area and in mountains. The maximum effect of gipocsition stahility increasing, CRAA consolidation and perfecting of efferention synthesis at high-mountainous gipobaroadaptation rats is more significant, thah at "flat." gipobaroadaptation has important protective significance for function of a brain, decreasing its sensibility to lock of oxygen and fixing maximum adaptive responses.

Adaptation, Physiological↗
PubMed1993

[The effect of high-altitude ecological and experimental stresses on the thrombocyte-vascular wall system].

Experiments in animals (rats) and examinations of the population of high-altitude shepherds were used to study the functional system "Thrombocytes-Vessel Wall" (STVW) for evaluation of the organism ecological adaptation to "pure" high-altitude stress, with and without combination with experimental-adrenergic cardionecrosogenic stress (ACNS, in rats). The adaptive increase of antiaggregation prostacyclin activity of the aorta in rats and PGI2 reaction of vessels in human population of high-altitude in mountains (2000, 3000-3500 m) were found to be a common biologist regularity. The adaptive increase of coronary reserve of the heart and vasodilatator-antiaggregation status in high-altitude shepherds correlated with an increase of antiaggregation activity of the aorta and decrease of spontaneous aggregation of the thrombocytes in rats under conditions of more prolonged adaptation to high-altitude ecological stress.

Adaptation, Physiological↗
PubMed1992

[Prostacyclin-thromboxane imbalance after adrenergic damage of the heart and aorta and its correction with calcium antagonist finoptin and the adaptation to high-altitude climate].

Adrenergic cardiac and aortic lesion was reproduced by using intramuscularly a stress-necrogenic epinephrine dose of 2 mg/kg. Following 24 hours, the levels of malonic dialdehyde (MDA) as a TxA2 marker, were measured in the platelets. The antiaggregability of the aortic wall where PGI2 is synthesized was also examined. The adrenergic lesion was found to impair the platelet function-vascular wall balance, creating the condition for enhancing spontaneous platelet aggregation. This led to 50% death of experimental "lowland" rats. The short-term high-altitude adaptation failed to substantially modify the death rates in adrenergic lesion, though the platelets showed a 30% decrease in MDA generation. The combination of high-altitude adaptation and the calcium antagonist finoptin completely prevented the stress-induced increase in the platelet generation of MDA, a TxA2 marker, which was followed by a drastic reduction (16.6% versus 50%) in sudden death cases among the rats during adrenergic cardiac and aortic lesion.

Adaptation, Physiological↗
PubMed1990

[The effect of alpha-tocopherol on conditioned reflex activity in adrenaline-induced myocardial dystrophy in rats].

Adrenolytic heart defect (AHD) proceeds with the breaking of higher adaptational reactions, i.e. the change of latent period of conditioned active prevention reaction and arising of retrograde amnesia. alpha-Tocopherol--antioxidant prevents the breaking of conditioned reflex activity and sharply reduces the mortality rate in AHD. More effective is the prophylaxis of the brain function breaking and lethality.

Adaptation, Physiological↗
PubMed1989

[Changes in lipid peroxidation and the antioxidative system of the myocardium in adrenaline-induced damage of the heart].

Epinephrine-induced cardiac injury (ECI) was simulated in rabbits. The indices of the system of peroxidation of lipids (LPO) and antioxidants were examined during various periods (3 hours, 3 and 9 days) of ECI. It was found that lower lipid antioxidative activity of blood, i.e. weaker body's antiperoxide protection, was found most early, then there was higher malonic dialdehyde (MDA) (a marker of thromboxane, TBA2) generation. The increase in antiperoxidase protection occurred at the level of the target organ (heart). There was a rise in the activity of the antioxidative enzyme superoxide dismutase and inhibited formation of primary products of LPO such as dien conjugates from early to 9 hours of the observation. When the natural antioxidant alpha-tocopherol was given prior to ECI, it prevented enhanced MDA formation in the platelets, optimized prostacyclin synthesis in the vascular wall, and stabilized blood lipid antioxidative activity.

Animals↗
PubMed1987

[Effect of adaptation to central highlands conditions on active avoidance conditioning and its retention after emotional pain stress].

The generation of conditioned reflex of active avoidance (CRAA) and its retention after emotional stress were studied in different groups of rats. The degree of conditioned reflex of active avoidance in pre-adapted rats was higher than in non-adapted animals. However, the degree of CRAA maintenance was independent of the character of CRAA fixation and the rats' adaptability after 1 and 3 exposures to emotional stress. In a usual degree of conditioned reflex fixation its maintenance was higher in rats living on the plain than in low-mountain rats (adapted and non-adapted).

Adaptation, Physiological↗
PubMed1984

[Changes in the homeostatic balance of prostacyclin-thromboxane generating systems during experimental social stress].

Chronic emotional stress leads to the reduction in prostacycline content in the vascular wall and to the elevation of the malonic aldehyde level in the platelets, with a simultaneous increase of the spontaneous platelet aggregation index. Antistressor and antiaggregation action of the adaptation to high mountains occurs at later times (day 30) in both normal and stress-exposed rats despite the fact that stress-exposed rats yield to normal ones as regards the magnitude of prostacycline activation in the vascular wall. This is accounted for by initial (before adaptation) stress-induced disturbance of the balance between prostacycline and thromboxan.

Acclimatization↗
PubMedDate not supplied

[Effect of hormone-induced stress and high altitude on the higher nervous activity of rats].

The hormonally induced stresses have been studied for their effect on higher nervous activity (HNA) of rats under conditions of low-(1760 m above the sea level) and highland (3200 m above the sea level). Hydrocortisone-induced stress (HIS) in mountains decreases to an optimal degree the latent period (LP) of conditioned reflex of active avoidance (CRAA) and strengthens differentiating inhibition (DI). In mountains and on plain it impedes appearance of extinctive inhibition (EI). DOCA-induced stress (DIS) has the same effect though in the emergency period of adaptation it sharply (unlike GIS) increases the number of cases of CRAA amnesia manifestation and prolongs their LP. ACTH-induced stress (AIS) makes the appearance of amnesia cases more frequent and prolongs LP of realized CRAA, unlike DIS, over all the periods of Alpine adaptation. However, DI strengthens, while EI is hindered irrespective of the altitude level. Injection stress in mountains occurs with deviations of HNA; the number of cases of the CRAA amnesia increases as well as differentiation disinhibition. DI fails rapidly being tested for strength. Adaptation of intact rats to highland occurs faithfully without essential changes of LP but with impeded development of EI.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Changes in conditioned reflex activity during adaptation of the rat to pressure-chamber and high-altitude hypoxia].

A group of rats with a stereotype of conditioned reflexes was preliminarily trained to hypoxia effects during 30 days (at the "altitude" of 6000 m, time of exhibition--from 10 to 60 min, for 18 days--only 60 min). Adaptive changes in the process of training consisted in a weakening of differentiation inhibition, partial amnesia of the conditioned reaction of active avoidance and appearance of phasic states (equalization and paradoxical phases) in the cerebral cortex. The following adaptation of hypoxia "trained" rats to new natural conditions of Alpine altitude (3200 m) proceeded favourably, without disturbance of differentiation inhibition and without phasic states. Rats without preliminary training to altitude chamber hypoxia, in mountains (3200 m) were subjected to moderate tension resulting in protective inhibition, partial amnesia and transient disturbance of differentiation inhibition.

Adaptation, Physiological↗