Biomedical subjects
Publications and source records attributed to A K Bhattacharya.
A brief description is given of an outbreak of foot and mouth disease in gayals (Bos gaurus frontalis) which occurred in Calcutta Zoo in October 1990. Four of the five affected animals died within ten days of onset of the disease. The disease did not spread to other animals in the Zoo.
We report in situ treatment, by focal hyperthermia, of a recurrent hepatoma in the transplanted liver of a 53-year-old man. Hyperthermia was generated by neodymium-yttrium-aluminum-garnet laser, which was delivered through a fiber placed inside a 19-gauge needle and inserted percutaneously into the liver under ultrasound guidance. The effect was monitored in real time by ultrasound and subsequently confirmed by computerized tomography and needle core biopsy. Objectively the tumor growth was halted for 3 months, indicating partial response to this minimally invasive treatment.
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Cyclic AMP binding in the extract of E. coli was taken as a measure of cAMP receptor protein (CRP) present in the cells. The gamma-irradiation of cells caused a dose-dependent inhibition of cAMP binding activity indicating that CRP gene is affected by gamma-irradiation. The binding activity in cells irradiated with 240 Gy gamma-ray dose remained unaltered by post-irradiation incubation. This supports previous finding that the enhanced inhibition of the L-arabinose isomerase synthesizing capacity, following incubation of gamma-irradiated cells at higher doses, must be due to a different cause than the catabolite repression.
The incorporation of [14C]adenine into the cyclic AMP fraction by whole cells of Escherichia coli B/r was taken as a measure of the in vivo adenylate cyclase activity. This activity was significantly inhibited by irradiation of the cells either with 60Co gamma-rays or with UV light from a germicidal lamp, suggesting inhibition of cyclic AMP synthesis. The incubation of cells after irradiation with lower doses (50-100 Gy) of gamma-rays produced a significant increase of in vivo adenylate cyclase activity, whereas there was no significant change after higher doses (150 Gy and above). Dark incubation of cells after irradiation with UV light (54 J m-2) led to recovery of enzyme activity to the level measured in unirradiated cells. Thus it appears that the catabolite repression of L-arabinose isomerase induced by UV light, as well as gamma-irradiation, is due to reduced cyclic AMP synthesis in irradiated cells.
Gamma irradiation of Escherichia coli B/r caused a dose-dependent inhibition of the capacity of the cells to synthesize L-arabinose isomerase in response to the inducer. At higher doses (18 krad and above), postirradiation incubation led to further inhibition of the capacity to synthesize L-arabinose isomerase, whereas cells receiving lower doses recovered from the damage to the enzyme synthesizing system following incubation. Cyclic AMP partially reversed the inhibitory effect on L-arabinose isomerase induction produced immediately after irradiation by all gamma-ray doses (up to 30 krad), but the enhanced inhibitory effect caused by induction in cells irradiated at higher doses could not be reversed by the nucleotide. It is suggested that although catabolite repression is partly responsible for causing the inhibition of the enzyme synthesizing capacity of the cells observed immediately after gamma irradiation, the enhanced inhibition caused by incubating cells irradiated at higher doses is not due to interference with the control mechanism regulated by catabolite repression.
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The differences in the distribution pattern of muscle fiber types between short-, middle-, and long-distance runners are well known. Since slow- and fast-twitch muscle fibers have different oxidative and glycolytic activities, lactate and pyruvate blood concentrations are expected to behave differently in athletes training in different sports disciplines after short exercise. Twenty-four well-trained athletes participated in the present study. The purpose of the investigation was to examine lactate and pyruvate blood concentrations during a 5-min treadmill exercise test at 6 km/h with a slope of 10% in short-, middle-, and long-distance runners and athletes of other disciplines (nonrunners). The highest and lowest post-exercise lactate and pyruvate levels were found in the short- and long-distance runners, respectively. In contrast to what was found in all other athletes, a decrease of the lactate-pyruvate ratio was observed in the middle-distance runners after exercise. The combination of both aerobic and anaerobic training in these athletes could account for this observation.
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The participants of inter-university "Kabaddi" competition showed higher values of height, weight and surface area than average Indian population, indicating better attainment of growth in them. Further, the values of respiratory efficiency tests like, FEV1, MEFR and PEFR were also observed to be more in these players, probably due to training effect. The grip strength values were high in comparison to those of Indian football goalkeepers and hockey players.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.