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Biomedical subjects

A K Frazer

Publications and source records attributed to A K Frazer.

6 recordsLinked to original sources
PubMed1979

Multiple disparate cranial neoplasms.

The case of a three-year-old girl with fibrosarcoma of the right orbit is presented. She was initially treated with surgery and later with radiotherapy. After an interval of thirty-three years she developed a suprasellar epidermoid cyst and two years later a right frontal meningioma. The two benign tumors fulfill the usual criteria for irradiation induced tumors and the possible role of radiotherapy in their induction is discussed.

Brain Neoplasms↗
PubMed1976

The reliability of prediction of outcome in spina bifida.

The clinical findings in 85 neonates with spina bifida were given to two neurosurgeons and two paediatricians, who were asked to predict from them the length of survival and quality of survival with regard to intellect, locomotion and continence, without their knowing the actual outcome. All four clinicians correctly predicted the survival of infants with meningocele, closed myelocele and encephalocele. The paediatricians correctly predicted the survival of all infants with open myelocele who actually survived, but also included some who had died. The surgeons correctly predicted the deaths of all those with open myelocele who actually died, but expected a considerable number to die who in fact survived. All four clinicians were similar in their predictions of intellect: they underestimated the outcome in patients with successfully shunted hydrocephalus, they overestimated the intellect in patients who had developed intracranial infection and shunt blockage, and they largely underestimated the outcome in the patients who did not require shunts. They made correct predictions for limb and sphincter function in nearly all the survivors. This investigation underlines the problem of selection for treatment caused by the inability to predict the complications of hydrocephalus and infection. Reasons for the differences between the expectations of the paediatricians and surgeons, and the implications of the results of this study for selection for surgery are discussed. It is suggested that limb paralysis and incontinence ought not to be considered as factors excluding infants from treatment.

Child↗
PubMed1973

Cranial and spinal meningiomas in a pair of identical twin boys.

A unique set of identical twin boys with spinal and intracranial meningiomas is described. Three distinct spinal tumours and one intracranial one were removed surgically. One intracranial meningioma has been symptomless, so far. The red cell and leucocyte groups of the two patients were found to be identical, and the probability of their being monozygous was estimated from these data as being 0·932 (Appendix).

Adolescent↗