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Biomedical subjects

A K Garg

Publications and source records attributed to A K Garg.

At least 55 records · Page 3Linked to original sources

A controlled trial of high-intensity double-surface phototherapy on a fluid bed versus conventional phototherapy in neonatal jaundice.

OBJECTIVE: To evaluate a simple, relatively inexpensive method using the fluid bed to provide high-intensity double-surface (HIDS) phototherapy and to confirm that the method described is more effective than conventional phototherapy (CPT) in the treatment of neonatal hyperbilirubinemia. DESIGN: Prospective controlled study. METHOD: HIDS phototherapy (26 to 30 microW/cm2 per nanometer) on the fluid bed (n = 22) versus conventional (7 to 10 microW/cm2 per nanometer) phototherapy (n = 28) was used to treat neonates weighing more than 1500 g with hyperbilirubinemia. RESULTS: After 24 hours of therapy, the bilirubin in the group receiving HIDS phototherapy was significantly lower. The mean rate of fall of bilirubin was 5.34 mumol/L per hour in the group receiving HIDS phototherapy versus 0.7 mumol/L per hour in the group receiving CPT. HIDS phototherapy on a fluid bed was well tolerated. CONCLUSION: HIDS phototherapy on the fluid bed is significantly more effective in reducing bilirubin than CPT. It can be easily and economically provided using equipment currently available in most neonatal units.

Beds↗

Xerostomia: recognition and management of hypofunction of the salivary glands.

Unfortunately, xerostomia manifests itself in the presence of multiple chronic and acute disease states. Hyposalivation can not only persist as a side effect related to the medical management and concomitant drug use in the treatment of the disease, but it may functionally impair our patients and affect their overall health and quality of life. It is the intent of this article to assist the clinician in the recognition of those disease entities that may induce the side effect of xerostomia. In addition, protocols for the management of decreased salivary flow for each of these conditions are reviewed.

Antineoplastic Agents↗

Radiographic modalities for diagnosis and treatment planning in implant dentistry.

Early in the development of implant technology it became apparent that conventional dental imaging techniques were limited for evaluating patients for implant surgery. During the treatment planning phase, the recipient bed is routinely assessed by visual examination and palpation, as well as by periapical and panoramic radiology. These two imaging modalities provide a two-dimensional image of mesial-distal and occlusal-apical dimensions of the edentulous regions where implants might be placed. When adequate occlusal-apical bone height is available for endosteal implants, the buccal-lingual width and angulation of the available bone are the most important criteria for implant selection and success. However, neither buccal-lingual width nor angulation can be visualized on most traditional radiographs. Although clinical examination and traditional radiographs may be adequate for patients with wide residual ridges that exhibit sufficient bone crestal to the mandibular nerve and maxillary sinus, these methods do not allow for precise measurement of the buccolingual dimension of the bone or assessment of the location of unanticipated undercuts. For these concerns, it is necessary to view the recipient site in a plane perpendicular to a curved plane through the arch of the maxilla or mandible in the region of the proposed implants. Implant dentists soon recognized that, for optimum placement of implants, cross-sectional views of the maxilla and mandible were the ideal means of providing necessary pre-operative information. Today, the two most often employed and most applicable radiographic studies for implant treatment planning are the panoramic radiograph and tomography. Although distortion can be a major problem with panoramic radiographs, when performed properly they can provide valuable information, and are both readily accessible and cost efficient. To help localize potential implant sites and assist in obtaining accurate measurements, it is recommended that surgical stents be used with panoramic radiographs. In simple cases, where a limited number of implants are to be placed, panoramic radiography and/or tomography may be used to obtain a view of the arch of the jaw in the area of interest. For complex, cases, where multiple implants are required, the CT scan imaging procedure is recommended. Because of its ability to reconstruct a fully three dimensional model of the maxilla and mandible, CT provides a highly sophisticated format for precisely defining the jaw structure and locating critical anatomic structures. The use of CT scans in conjunction with software that renders immediate "treatment plans" using the most real and accurate information provides the most effective radiographic modality currently available for the evaluation of patients for oral implants. To follow patients after implant surgery, DSR can be helpful by addressing the limitations of other radiographic modalities in detecting postoperative changes. By eliminating unchanged information, DSR allows the clinician's eye to focus on actual changes that have occurred between the recordings of two images.

Cephalometry↗

Pulmonary penicillosis marneffei: report of the first imported case in Canada.

A 57-year-old female, born in Laos and who had lived in Thailand prior to immigrating to Canada in 1989, was seen by her physician with a chief complaint of cough and dyspnea. Her chest X-ray showed bilateral pulmonary air fluid levels. A fungus, with a diffusible red pigment, tentatively identified as Penicillium marneffei, was isolated from the patient's bronchial washings and sputum specimens. At 37 degrees C, the fungus converted to a yeast form when cultured on brain heart infusion agar. Microscopic examination of this culture revealed yeast cells that reproduced by fission. The identity of the patient's isolate was confirmed as P. marneffei with an exoantigen test. The patient's serum demonstrated specific antibodies to P. marneffei antigen. Treatment with amphotericin B and ketoconazole resulted in clinical improvement, clearing of chest X-rays and conversion to sero-negativity. Our case is the first recorded diagnosis of imported penicillosis marneffei in Canada. The minimal inhibitory concentrations recorded for the patient's isolate to fluconazole, 5-fluorocytosine, itraconazole and miconazole were 12.5, 0.39, < 0.195 and < 0.195 micrograms/ml, respectively.

Amphotericin B↗

Double surface phototherapy on a fluid bed.

Jaundice is a common neonatal problem with a higher incidence in premature infants. Phototherapy is an established treatment modality, effective and safer than exchange transfusion. Double surface phototherapy is more effective. The present methods have drawbacks, viz limited availability, high cost of equipment and difficulties in nursing infants during phototherapy. A modification to the technique which overcomes these difficulties made with equipment available in most neonatal units is described with three case reports of hyperbilirubinaemia successfully treated using this method.

Bilirubin↗

Isolation of bluetongue virus from sheep in Rajasthan State, India.

A cytopathic agent was isolated in a baby hamster kidney (BHK)-21 cell-line from blood samples of cross-bred sheep showing typical bluetongue symptoms at Avikanagar in Rajasthan State, India. The cytopathic agent was identified as a bluetongue virus (BTV) by immunofluorescence, the immunoperoxidase test and electron microscopy of BHK-21 cells infected with the new isolate. The new isolate was typed as BTV serotype 1.

Animals↗

Postextraction ridge maintenance using the endosseous ridge maintenance implant (ERMI).

Classically, alveolar bone height in the maxilla and mandible is naturally lost by resorption soon after exodontia; or subsequently by pressure that is exerted on the edentulous ridge by the removable denture. As the alveolar bone is resorbed, the only alternative given to the dental practitioner in the past was to constantly reline the removable prosthesis. With the ERMI, the postextraction edentulous ridge can be sustained; thus reducing the physiological and retentive complications encountered by the patient over time. The intent of this article is to review the physiology of the ERMI in bone, describe in detail the basic placement procedure, as well as discuss the indications and contraindications to the use of the Endosseous Ridge Maintenance Implant System.

Alveolar Bone Loss↗

The importance of asepsis in dental implantology.

All surgical procedures, including dental implantation, involve certain risk factors. One of the most common is that of postoperative infection. The harsh realities of today's medical environment such as the threat of blood-borne pathogens and transmittable infections, the increased cost of hospitalization, and the increase in malpractice suites against surgeons, make it imperative that all surgeons follow safe and sterile surgical protocols that reduce the chances of infections and ensure satisfactory results.

Asepsis↗

In vitro susceptibility of mycelial and yeast forms of Penicillium marneffei to amphotericin B, fluconazole, 5-fluorocytosine and itraconazole.

The mycelial (25 degrees C) and yeast-like (37 degrees C) forms of Penicillium marneffei clinical and type strains were investigated for their in vitro susceptibility to amphotericin B (AmB), 5-fluorocytosine (5-FC), fluconazole (FLU) and itraconazole (ITZ), using Bacto antibiotic medium 3, yeast-nitrogen, Sabouraud's dextrose (pH 5.7) and high resolution (pH 7.1) broth media (1ml/tube), respectively. Results indicated that the minimal inhibitory and minimal fungicidal concentrations (MICs and MFCs) for the mycelial cultures of P. marneffei to AmB were in the range 0.78-1.56 and 0.78-3.125 micrograms/ml, respectively, as against 3.125-25 micrograms (MICs) for the yeast form cultures. The MFCs to AmB for the yeast form were one dilution higher. The MICs to FLU were generally lower for the yeast form (6.25-25 micrograms) than the mycelial form (25-50 micrograms/ml), whereas MFCs for the mycelial cultures were > 100 micrograms as compared to 6.25-100 micrograms for their yeast form. The MICs for the mycelial form to 5-FC ranged from < 0.195-0.39 microgram. Higher MICs (6.25 micrograms) were recorded for their yeast form. The MFCs to 5-FC for the yeast form were 25-100 micrograms/ml. The MICs for the mycelial form to ITZ ranged from < 0.195 to 3.125 micrograms/ml. Higher values (< 0.195-50 micrograms) were recorded for their yeast-like form. The MFCs to ITZ for mycelial and yeast forms ranged from < 0.195-0.39 and 25-100 micrograms/ml, respectively. Results indicate that P. marneffei's yeast form is more sensitive to FLU and ITZ (8 of 10 strains) while the mycelial form displayed greater susceptibility to AmB and 5-FC. The MICs for ITZ remained steady in SD medium, pH 5.7 to 7.1. However, some strains gave higher MIC values (0.39-1.56 micrograms/ml) when tested in the HR.

Amphotericin B↗

Burns with pregnancy--a review of 25 cases.

We have treated 25 pregnant patients with burns over a period of 6 years (1986-91). During this period total admissions to the burn unit were 1260. There were 187 women of child-bearing age, with burns ranging between 15 and 100 per cent TBSA. We would like to emphasize that, with proper care, the prognosis of patients with burns who are pregnant is encouraging and is comparable to any other routine burn patient. Abortion was common in the first trimester of pregnancy. Septicaemia was the commonest cause of abortion. Fetal death is not always preceded by maternal death.

Abortion, Spontaneous↗