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Biomedical subjects

A K German

Publications and source records attributed to A K German.

At least 19 recordsLinked to original sources
PubMed1992

[The erythrocyte composition of the peripheral blood in tobacco smokers].

Data of cytometry and acid erythrography were evaluated in 60 tobacco smokers and 30 non-smoking healthy persons depending on length of smoking. Tobacco smoking was found to effect blood erythrocytes. Five-year smoking resulted in an increase of macrocytes, young resistant cells. Toxic signs were less pronounced concerning the resistance of circulating red cells. 6-10 years duration of smoking resulted in toxic lesions of the circulating erythrocytes confirmed by an increase of the number of spherulation-altered and low-resistant cells, early onset and late termination of hemolysis, increase of the percent of perished cells.

Adult↗
PubMed1991

[The effect of smoking on the composition of the peripheral blood in normal subjects].

The peripheral blood erythrocytic and leukocytic status was studied in 60 healthy young tobacco-smokers and in 30 non-smokers. The smokers were divided into two subgroups, each with 30 members: those smoking for not more than 5 years and those smoking for 6 to 10 years. A trend to inhibition of erythro- and leukocytopoiesis was detected in Subgroup 1 tobacco smokers: reticulocyte maturation rate was reduced, as was bone marrow production and the level of circulating red cells, macrocyte count was increased and planocytosis was likely to develop, leukocyte counts were decreased at the expense of the neutrophils, eosinophils, and monocytes; basophil count was growing. Subgroup 2 tobacco-smokers presented with normalization of erythro- and leukocytopoiesis: reticulocyte maturation rate was growing, as was bone marrow production and the count of circulating red cells, erythrocytogram normalized, leukocyte count was increasing at the expense of the neutrophils, eosinophils, and lymphocytes; basophil count has decreased. The detected changes in the peripheral blood erythro- and leukocytic composition, related to the duration of tobacco-smoking, appear to reflect different phases of tobacco smoke toxic product effects on the bone marrow and the formation of the defense, adaptive, allergic, and immunologic reactions of the body in conditions of prolonged tobacco antigenemia.

Adult↗
PubMed1991

[The effect of tobacco smoking on tissue oxygen balance].

Oxygen tension (pO2) in the muscles was studied in 90 healthy young males: 60 were tobacco (cigarette) smokers and 30 were non-smokers. In the smokers pO2 in the muscles was higher than in the non-smokers. Functional tests revealed worsening of O2 to the tissues and reduced tissue metabolism intensity. The latter occurred against the background of quantitative and qualitative compensatory reactions of pO2 regulation mechanisms directed for improvement of O2 transport and tissue aeration indicating a negative effect of smoking on the capacity of tissue cells to utilize O2 in aerobic breathing.

Adult↗
PubMed1991

[The antitryptic activity of the blood in pulmonary tuberculosis patients who smoke tobacco].

The general activity of the antitryptic system of the blood was studied in 60 practically healthy persons and in 65 patients with active tuberculosis. A group of tobacco smokers (5 years, 6-10 years) was singled out. It was established that tobacco smoking and pulmonary tuberculosis was accompanied by activation of the antitryptic system which should be considered as a peculiar defensive reaction of the body to increase of the proteolytic activity of enzymes in the lungs. In persons that have been smoking from 6 to 10 years there was a reduction of the general antitryptic activity which can further the development of dystrophic changes in the pulmonary parenchyma and produce an unfavourable effect on the course of specific inflammation.

Adult↗
PubMed1990

[Lung volume, capacity and alveolar ventilation in smokers].

Pulmonary volume and capacity as well as the intensity of alveolar ventilation depending on the length of smoking were examined in 60 practically healthy smokers and 30 non-smoking males. It was established that smokers with a smoking length of 6-10 years revealed a significant increase of residual pulmonary volume, volume of breathing dead space and a reduction of the alveolar ventilation/minute pulmonary volume ratio indicating a reduction of the amount of ventilated air. The revealed changes are results of a reduction of the pulmonary elasticity due to development of restrictive disorders in the parenchyma.

Adult↗
PubMed1989

[Hemoglobin functional activity in smokers].

Production, heterogeneity and functional activity of hemoglobin were studied in 60 practically healthy young smokers depending on the length of smoking. Those smoking under 5 years showed an increase of oxygen capacitance of the blood which is a response reaction to hypoxia; those smoking for 6-10 years showed changes of these values that may be interpreted as an adaptation reaction to chronic hypoxia. The functional activity of hemoglobin was reduced.

2,3-Diphosphoglycerate↗
PubMed1989

[Study of peripheral blood thrombocytes in smokers].

Total circulating platelet count and thrombocytogram were examined in 60 tobacco smokers and in 30 nonsmoking normal subjects aged 23-32. The smokers were divided into two subgroups, 30 subjects in each: Group 1 included those with a history of smoking under 5 years and Group 2 those smoking for 5 years and Group 2 those smoking for 6-10 years. The platelet count was found increased in Group 1 smokers at the expense of old, atypical, and involutional forms. In Group 2 smokers the total platelet count and the counts of their differentiation forms were reduced. This evidences the effect of tobacco smoking on circulating platelets, this effect depending on the length of tobacco smoke inhalation.

Adult↗
PubMed1989

[Treatment efficacy in destructive forms of pulmonary tuberculosis in relation to the methods of administering rifadin and isoniazid].

The efficacy was studied of 130 patients with freshly detected destructive forms of pulmonary tuberculosis depending on the method of administration of rifadin and isoniazid. Treatment of pulmonary tuberculosis was realized with rifadin, isoniazid and streptomycin. Three groups of patients were distinguished. In group I rifadin and isoniazide was taken orally, in group II--rifadin was administered orally and intrabronchially, isoniazid--orally. In group III rifadin was orally and intrabronchially, isoniazid--intravenously. The treatment was more effective with combined administration of rifadin and intravenous administration of isoniazid.

Administration, Inhalation↗