Biomedical subjects

A K H Chan

Publications and source records attributed to A K H Chan.

3 recordsLinked to original sources

PubMed2006

Risk factors of long bone fracture in non-ambulatory cerebral palsy children.

OBJECTIVES: To identify the risk factors for long bone fractures in non-ambulatory cerebral palsy children. DESIGN. Case-control study. SETTING: A residential rehabilitation centre in Hong Kong. PATIENTS: The fracture group comprised 19 (13 male, 6 female) cerebral palsy children aged 4 years 5 months to 18 years 11 months (mean, 10 years; standard deviation, 3 years 9 months), who had their first long bone fracture during the period June 1992 to May 2001 inclusive. The control group was composed of 90 (46 male, 44 female) concomitant cerebral palsy residents aged 6 years 1 month to 16 years 11 months (mean, 9 years 11 months; standard deviation, 2 years 4 months) with no history of long bone fracture. MAIN OUTCOME MEASURES: Presence of features considered relevant to the risk of fracture, namely: anthropometry, feeding practice, orthopaedic surgery and duration of postoperative immobilisation, extremity contracture, anti-epileptic medications, and general health status in the 12 months prior to the fracture. RESULTS: Of the 19 fracture episodes, 18 occurred in the femur and one in the tibia/fibula. Multivariate analysis revealed that weight for age Z scores (adjusted odds ratio=0.41, 95% confidence interval, 0.19-0.86) and recent postoperative immobilisation (weeks) [adjusted odds ratio=1.35, 95% confidence interval, 0.97-1.89] were independent predictors for fracture occurrence. CONCLUSION: Early intervention targeting these risk factors may reduce the fracture risk in non-ambulatory cerebral palsy children.

Adolescent↗

PubMed2002

Paediatric stroke: case series.

Five cases of paediatric stroke are reported. Two patients presented with idiopathic stroke, another following vertebral artery dissection, one secondary to Moyamoya disease, and one patient with the syndrome of mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes. The presentation, investigation, and management of paediatric stroke are discussed.

Adolescent↗

PubMedDate not supplied

Congenital absence of portal vein presenting as hepatopulmonary syndrome.

A 9-year-old girl presented with cyanosis and decreased exercise tolerance. Chest X-ray, lung function and echocardiogram were normal. Contrasted echocardiogram showed intrapulmonary right to left shunt and computerized tomography of the thorax showed dilated pulmonary vasculature. There was no arteriovenous malformation. Computerized tomography of the abdomen revealed absence of the intrahepatic portion of the portal vein. The superior mesenteric and splenic veins joined as a common trunk, bypassed the liver and drained into the right atrium. We concluded that the patient had hepatopulmonary syndrome secondary to absence of the portal vein. This is the first report of hepatopulmonary syndrome in a female paediatric patient with a congenital absence of the portal vein. As all portal blood entered directly into systemic circulation, the condition was equivalent to congenital portosystemic shunt. Cases of congenital portosystemic shunt complicated by hepatopulmonary syndrome were also reviewed.

Child↗