Bunyaviridae: morphologic and morphogenetic similarities of Bunyamwera serologic supergroup viruses and several other arthropod-borne viruses.
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Biomedical subjects
Publications and source records attributed to A K Harrison.
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Lagos bat virus and an isolate from shrews (IbAn 27377), both from Nigeria, were found to be bullet-shaped and to mature intracytoplasmically in association with a distinct matrix. They were related to, but readily distinguishable from, rabies virus and each other by complement fixation and neutralization tests. The three viruses, including rabies, form a subgrouping within the rhabdoviruses.
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Ultrathin sections of brain tissue from mice infected with three Bunyamwera group arboviruses, Bunyamwera, Tensaw, and Maguari, were examined by electron microscopy. In all three cases, virus was observed budding from membranes into intracytoplasmic cisternae. Mature virus was found accumulated within these distended cisternae and in extracellular spaces. The three viruses were morphologically indistinguishable; particles were round or oval, 98 nm in diameter, and had a closely adherent irregular envelope.
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