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Biomedical subjects

A K Hati

Publications and source records attributed to A K Hati.

At least 19 recordsLinked to original sources

Emerging Plasmodium falciparum in an endemic area in Calcutta.

Calcutta is now intensely malarious. Malarial infections are detected in every month. In an endemic area in central Calcutta a year-long study from August 1996 to July 1997 reveals that 31.47% of all cases are due to Plasmodium falciparum infection. A competition is going on between P vivax and P falciparum to gain upperhand. An equilibrium is there in the month of January (1997), when P vivax and P falciparum cases constitute 51.13% and 49.43% respectively. The highest and lowest percentage of P falciparum infection is in December 1996 (67.98%) and in May 1997 (0.89%) which is just reverse in the case of P vivax in December 1996 (33.60%) and in May 1997 (99.10%). Three imported cases of P malariae have been detected but the patients cannot be traced. Six cases of mixed infections have been found.

Animals

Urban malaria vector biology.

One of the main reasons for the set-back in the urban malaria control programme is the peculiar biobehaviour of the principal urban malaria vector Anopheles stephensi. Certain relevant facts such as incrimination as the vector of malaria, sibling or biological species, resting habitat, manlanding behaviour, seasonal prevalence, blood meal analysis, longevity, parity status, daily survival and mortality rates of adults, breeding habitats and vertical distribution of larvae of An. stephensi have been discussed. Determination of density of the vector using various parameters and their relation to malaria endemicity in an urban situation have been reviewed. An. stephensi has become resistant to DDT, HCH, malathion and propoxur in many places in India. Hence for control source reduction, use of predators such as fish and biolarvicides such as Bacillus thuringiensis var israelensis H14 and B. sphaericus, personal protection, i.e., use of appropriate clothing, bed nets, indigenous repellents, etc., information, education and communication (IEC) are to be stressed.

Adult

Recent epidemiological status of malaria in Calcutta Municipal Corporation area, West Bengal.

In Calcutta, Plasmodium falciparum cases and death due to malaria show remarkably increasing trend since 1990. The incidence of P. falciparum malaria has increased more than eleven folds in 1996 in comparison to 1990, with 0, 0, 0, 3, 7, 52 and 17 deaths in 1990, 1991, 1992, 1993, 1994, 1995 and 1996 respectively. Situation is more serious than what it is projected in official records as annual blood examination rate (ABER) in Calcutta Municipal area is poor, varying from 1.5 to 3.9 in 1993 and 1996 respectively. This is further evident from the fact that in a study area in 19 months (January 1995 to July 1996) the slide positivity rate (SPR) was 47.94% on an average 28.72% suffer from P. falciparum infection (as low as 0.5% in June 1996 and as high as 71.5% in November 1996). For the first time resistance of P. falciparum to chloroquine has been noted at RII and RIII level. The response of the same parasite strain to sulfa-pyrimethamine combination drug is very much promising. Fresh infection is occurring in all the months of the year and the favourable period is from July to November 1995 that is corroborating with Container index and Breteau index related to the vector mosquito Anopheles. Susceptibility status of An. stephensi indicates that the mosquito species has acquired resistance to DDT, BHC, propoxure and malathion but is still susceptible to fenthion and deltamethrin.

Animals

Effect of DDT on Phlebotomus sandflies in Kala-Azar endemic foci in West Bengal.

Phlebotomous argentipes, the vector of Kala-azar was found susceptible to DDT and found to reappear in the nine months after one time DDT spray at the rate of lg/m2 in three endemic foci of districts North and South 24-Parganas of West Bengal. Ph. papatasi, the other predominant species found resistant to DDT appeared within one month of DDT spray.

Animals

Indoor resting anophelines of north Bengal.

A systematic survey was carried out between April 1993 and March 1994 to study the distribution and prevalence of anopheline mosquito species in two malaria-prone areas situated in the foothills of Darjeeling district. Ten different species of Anopheles viz. An. aconitus, An. annularis, An. barbirostris, An. culicifacies, An. fluviatilis, An. hyrcanus group, An. maculatus, An. subpictus, An. vagus and An. varuna were collected. Per man hour density of mosquitoes collected was 4.5 and the most prevalent species was An. vagus, comprising 63% of the total catch. An. fluviatilis, an efficient vector of malaria in the foothill regions of India, was reported for the first time from this area. However, the classical vector of this region viz. An. minimus was altogether absent during the course of the present survey. All the ten species were found in cowsheds while, human habitation harboured higher population density (56.5%) of the total catch.

Animals

Transmission of Sarcoptes scabiei from animal to man and its control.

Outbreak of Sarcoptes scabiei in animals spilling over to man in close association was observed in two adjacent villages, Fewgram and Nurpur in the district of Birbhum, West Bengal, from mid-November to mid-December, 1991. Nineteen goats and one calf who did not receive any treatment died of sarcoptic manage. All infected animals got cured with external application of deltamethrin, a synthetic pyrethroid and triazapentadiene. Human cases were treated successfully with benzene hexachloride (2%).

Adult

An institutional outbreak of hepatitis E--reported first time from Calcutta city.

A sudden outbreak of hepatitis occurred in a micro-epidemic form, amongst the staff members of the School of Tropical Medicine, Calcutta, during May-June, 1995. A total of 21 persons developed jaundice, out of whom 11 members who attended the Virology Department and were tested for detection of different serological markers of hepatitis by ELISA. All the sera (N = 11) showed evidence of non-A, non-B infection by process of exclusion and 9 of the above sera showed evidence of anti-HEV when tested specifically. This is the first documented outbreak of viral hepatitis in respect of Calcutta.

Adult

Susceptibility status of Phlebotomus argentipes to DDT, dieldrin and malathion in Hoogly, West Bengal.

Susceptibility tests were carried out with DDT (4%), dieldrin (0.4%) and malathion (5%) using the WHO test kits against Phlebotomus argentipes sandflies collected from Dankuni, situated in Hoogly district, 21 km from Calcutta, West Bengal. P. argentipes was found to be susceptible to all the three insecticides tested. LT 50 was calculated to be 10.6 minutes, 10.2 minutes and 2.8 minutes for DDT, dieldrin and malathion against the flies.

Animals

Anophelines of Siliguri-Naxalbari block, Darjeeling, West Bengal.

A systematic survey has been carried out during 1993-94 to study the occurrence and distribution of anopheline mosquitoes in Siliguri-Naxalbari block of Darjeeling district. The anopheline fauna of this region consists of 13 species, namely, An. vagus, An. culicifacies, An. annularis, An. barbirostris, An. subpictus, An. maculatus, An. tessellatus, An. jamesii, An. aconitus, An. "hyrcanus" group, An. karwari, An. fluviatilis and An. jeyporiensis among which the first five species forms the major bulk (92%). All the species showed preference to cattlesheds than human-habitation for resting. The ratio between morning and evening collection was 1:0.87.

Animals