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Biomedical subjects

A K Khattab

Publications and source records attributed to A K Khattab.

17 recordsLinked to original sources

Rheumatic fever and rubella immunity.

Anti-rubella IgG titer was estimated in 106 children: sixty five had acute rheumatic fever and 41 had either a history of rheumatic fever or a definite rheumatic heart disease. Their ages ranged from 6 to 16 years old (11.4 +/- 2.7 years). Sixty two were females and 44 were males. They were compared with 35 control normal subjects of both sexes with no history of rheumatic affection, aged 5 to 14 years (10.2 +/- 3.6 years). The results obtained showed a significantly (p less than 0.001) higher rubella IgG titer level in the controls (1066.5 +/- 8.3) as compared to the rheumatic cases (521.2 +/- 3.0). No differences were found in the rubella antibody titer between cases of acute rheumatic fever and those with history of rheumatic fever or rheumatic heart disease, nor between males and females in either cases or controls. We suggested that the low rubella IgG levels encountered in the rheumatic cases, make them more susceptible to rheumatic fever affection. In other words, a high immunity level against rubella might also produce an immunity against an agent, possibly related to rubella virus, with a specific role in the development of rheumatic fever. Vaccination against rubella could be worth a trial, for prevention of rheumatic fever.

Adolescent↗

Profile of liver disease in Egyptian infants and children.

The causes of hepatopathies were studied retrospectively in a group of 200 infants who were inpatients at the Paediatric Department of Ain Shams University, Cairo, over the period 1977-1981, and prospectively in 50 children who were outpatients of the Paediatric Hepatology Clinic over the period October 1982-March 1983. The main cause of hepatopathy in both groups was hepatitis, followed by protein-calorie malnutrition in infants and bilharziasis in children. Suggestions are made as to methods of prevention.

Child, Preschool↗

Hepatic succinic dehydrogenase in marasmic Egyptian infants.

In a group of 15 marasmic infants, the activity of the liver enzyme "succinic dehydrogenase" (SDH) was studied. This was compared with the activity of that enzyme in the livers of 10 normal infants, taken as controls. Histologic changes were found in only one third of the marasmic cases studied while abnormal liver functions were noted in two thirds of them and diminished SDH activity in all of them. The presence of diminished activity of SDH in 100% of the cases may explain the discrepancy between the occurrence of histologic hepatic changes in about 33% only and the occurrence of disturbed liver functions in about 66% of the cases.

Egypt↗