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Biomedical subjects

A K Mukherjee

Publications and source records attributed to A K Mukherjee.

At least 55 records · Page 3Linked to original sources
PubMed1988

Diaphyseal dysplasia associated with anemia.

Five patients in early childhood had moderate to marked anemia and clinically demonstrable thick long bones of the extremities with radiologic features of diaphyseal dysplasia. Although the anemia was persistent and not responsive to hematinics, prednisolone was administered to two of these patients and caused remarkable improvement of the anemia in both. Roentgenologic examination carried out after 1 year of corticosteroid therapy in one patient and after 11 years in another showed considerable improvement of the bony changes. The clinical and radiologic examinations of these patients and their follow-up study suggest that they may constitute an unusual group of patients with diaphyseal dysplasia associated with anemia, hitherto not well defined.

Anemia↗
PubMed1988

Evaluation of serology as a tool for malaria surveillance in East Champaran District of Bihar, India.

The indirect immunofluorescence test was evaluated as a tool for malaria surveillance. The population of 12 villages in the East Champaran District of Bihar with a low annual parasitic index and a low annual blood examination rate was surveyed in order to confirm the low endemicity of malaria in these villages. Two specimens of blood, one taken during the pre-transmission season and one taken during the post-transmission season, were collected for parasitological and serological studies. The paired samples showed no parasite positivity in the study population in both surveys. All the villages had very low serological titres. However, the presence of malaria antibodies in the zero to five years age group (the sentinel group) indicated that malaria transmission occurred in the study area at a very low level. The seropositivity and the geometric mean titre were lower in the pre-transmission season than in the post-transmission season, but the overall reduction in geometric mean titre, which was very low throughout the study, was not statistically significant. The study emphasizes the importance of serological tests in malaria surveillance.

Adolescent↗
PubMed1987

Epidemiology. The incidence and management of joint contracture in India.

An epidemiologic study in India showed that 50% of the severely disabled (1.8% of the total population) had locomotor disorders. There is a considerable difference in the incidence of disability and disease in rural and urban populations. The deformities from poliomyelitis are encountered predominantly in the rural areas (53.5%). The incidence in urban areas is only 1%. After poliomyelitis, the pathomechanics of deformity are prominent in the lower limbs. In a developing country, the management of contractures differs considerably from treatment in economically advanced nations. The use of postural exercises with body weight is well illustrated by certain Yoga postures such as paschimottansana or ushtrasana and is a prescribed treatment.

Adolescent↗
PubMed1986

Immunochemical properties of the lipopolysaccharide O-antigen of Vibrio cholerae O1 in relation to its chemical structure.

D-Glucuronic acid and D-glucosamine have an immunodominant role in the lipopolysaccharide (LPS) O-antigen of both the Ogawa and the Inaba subtypes of Vibrio cholerae O1. This was evident from the pronounced inhibitory effect on the LPS precipitin reaction demonstrated by these monosaccharides and by oligosaccharides containing either of them which were isolated from LPS hydrolysate. There was a considerable decrease in the antibody-combining capacity of chemically modified LPS in which the carboxyl group of the glucuronic acid had been reduced. Similarly, on deamination, the O-specific polysaccharide fraction of the LPS molecule from both subtypes completely lost the ability to precipitate the LPS antibody.

Antigens, Bacterial↗
PubMed1986

Primary tuberculosis of the retina.

A case of pseudoglioma diagnosed on histopathology to be retinal tuberculosis is presented with a general review of the literature on ocular tuberculosis. The case is peculiar in that retinal tuberculosis occurred without concomitant involvement of the choroid.

Child, Preschool↗
PubMed1985

Glucose metabolism in insulin administered euthyroid, hypothyroid and hyperthyroid rats.

Glucose metabolism was studied as evidenced by the sugar and pyruvic acid levels in blood and glycogen and pyruvic acid content of tissues in euthyroid, hypothyroid and hyperthyroid rats by giving insulin. Results show that in a normal thyroxine-excess insulin state, the rise in blood sugar was less, glycogenesis was much enhanced and glycolysis was reduced in comparison to these data in the euthyroid state. When tyroxine deficiency was associated with excess insulin, glycogenesis was enhanced further and an almost complete inhibition of glycolysis was observed. In excess thyroxine-excess insulin state glycogenesis was increased at the expense of glycolysis in comparison to the finding in the hyperthyroid state. Thus exogenous insulin in the euthyroid state altered the pattern of carbohydrate metabolism enhancing glycogenesis and inhibiting glycolysis. In a low thyroxine-excess insulin state, further enhancement of glycogenesis and inhibition of glycolysis were observed. But in an excess thyroxine-excess insulin state, the higher thyroxine activity was somewhat neutralized by higher insulin action allowing glycogenesis with glucose to proceed to some extent.

Animals↗
PubMed1984

Studies on Escherichia coli as a cause of acute diarrhoea in Calcutta.

The prevalence of different types of diarrhoea-producing Escherichia coli among 240 patients with acute diarrhoea in hospital was investigated. The 25 patients (10.4% of the total) from whose faeces we isolated enteropathogenic E. coli (EPEC) were all less than 5 years old but the 29 (12.1%) from whom we isolated enterotoxigenic E. coli (ETEC) were of various ages, most of them greater than 12 years old. No enteroinvasive E. coli (EIEC) strains were isolated. ETEC strains that produced heat-labile toxin (LT) were encountered more often than those that produced either heat-stable toxin (ST) alone or both LT and ST. The ETEC isolates were distributed among eight different serotypes, the commonest being O148:H28 (38%). Correlations between enterotoxin production, serotype pattern and possession of colonisation factor antigens I and II were observed.

Acute Disease↗
PubMed1983

The cytoplasmic 4 S translation inhibitory RNA species of chick embryonic muscle. Effect on mRNA binding to 43 S initiation complex.

A cytoplasmic 10 S ribonucleoprotein (iRNP) isolated from chick embryonic muscle is a potent inhibitor of mRNA translation in vitro and contains a 4 S translation inhibitory RNA species (iRNA) (Sarkar, S., Mukherjee, A. K., and Guha, C. (1981) J. Biol. Chem. 256, 5077-5086). Using an in vitro assay system, we show that the iRNA has no effect on the elongation phase of peptide synthesis. iRNA inhibits translation at the initiation step by inhibiting mRNA binding to 43 S initiation complexes. The iRNA does not inhibit the binding of Met-tRNAf to the 40 S ribosomal subunit, but rather causes an increase in the level of 43 S initiation complexes in the reticulocyte lysate. The formation of the 80 S initiation complex from the 43 S complex is specifically blocked in the presence of iRNA. The significance of these results in relation to biological function of iRNA is discussed.

Animals↗
PubMed1983

Studies on the partial structure of the O-antigen of Vibrio cholera Ogawa G-2102.

Detailed information was obtained regarding the partial structure of the lipopolysaccharide (LPS), containing glucose, glucuronic acid, 2-amino-2-deoxy-glucose, L-glycero-D-gluco-heptose, and small proportions of L-glycero-D-manno-heptose, mannose, and galactose, isolated from Vibrio cholera Ogawa G-2102. Structures of three oligosaccharides were determined. Results of deamination experiments established the sequence of the linkages between the amino sugar and heptose residues in the O-antigenic polysaccharide.

Antigens, Bacterial↗