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Biomedical subjects

A K Prabhakar

Publications and source records attributed to A K Prabhakar.

22 records · Page 2Linked to original sources
PubMedDate not supplied

Natural history of precancerous and early cancerous lesions of the uterine cervix.

A prospective study of cervical dysplasia cases and control cases matched for age and parity was undertaken in search of factors related to cervical carcinogenesis. Cytologic examination of 66,736 women revealed negative findings in 28.5%, inflammation in 70.3%, dysplasia in 1.4% and carcinoma in 0.1% of the cases. Data on epidemiologic features, cytomorphologic characteristics and serologic findings of antibodies to herpes simplex virus (HSV) were collected for proven cancer patients, dysplasia cases and control subjects. Cancer patients revealed significantly elevated antibodies to HSV as compared to the controls. The analysis revealed a higher proportion of dysplasia cases with an age at consummation of marriage of less than or equal to 15 years as compared to controls, with a relative risk of 1.5 (P less than .05). Similarly, a higher proportion of women with dysplasia had HSV-II-specific antibodies as compared to control women. The relative risk was found to be 1.3, which was not statistically significant (P greater than .05). The Mantel-Haenszel summary relative risk between antibodies to HSV and the two groups (dysplasia cases and controls), adjusted for the age at consummation of marriage, worked out to be 1.38, which was also statistically not significant (P greater than .05). The overall progression rate of dysplasia to malignancy was found to be 11.7% at the end of 54 months (during a total follow-up period of 84 months). Progression to cancer was highest in severe dysplasia cases and less in mild dysplasia cases. The progression rates were also significantly higher in the group of women who revealed antibodies to HSV II. Similar differences in the progression rates were observed with regard to the age at consummation of marriage.

Adult↗
PubMedDate not supplied

Cytologic monitoring of women using copper-containing intrauterine devices: five-year follow-up study.

Cytologic monitoring of the epithelia of the female genital tract in 2,603 women using copper-containing intrauterine devices (Cu IUDs) was carried out, with a detailed cytomorphologic study of the cervical smears. The women were followed-up to a maximum period of 60 months of study. The rate of dysplastic lesions in the initial smears was 2.5%. Grouping the 60 months into five time intervals of one year each, the annual rates of dysplasia at follow-up were 4.2%, 1.6%, 3.8%, 0.9% and 3.0%. The rate of dysplasia development in women with initially negative or inflammatory smears did not change significantly during the five years. No dysplasia progressed to carcinoma during the follow-up period. No difference in the behavior of dysplastic lesions detected at the initial stage as compared to those developing during the course of Cu IUD use was observed during the study. This study indicated that there is no significant risk of an increased incidence of cervical dysplasia or carcinoma development in women using copper-containing IUDs for five years.

Adolescent↗