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Biomedical subjects

A K Rawat

Publications and source records attributed to A K Rawat.

At least 19 recordsLinked to original sources
PubMed2006

Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures.

OBJECTIVE: To evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures. METHODS: Prospective randomized study. Total 125 children of all ages of either sex, for seizure episode (n-76) and various invasive and non-invasive procedures (n-49) received either intranasal midazolam (0.2 mg/Kg) or intravenous diazepam (0.3 mg/Kg). RESULTS. Mean time from arrival at hospital to starting treatment was significantly shorter in midazolam group compared to diazepam group [2.34+/-0.90; minute vs 4.61+/-1.08 minute p< 0.001]. Mean time to control seizures after arrival in hospital was significantly shorter in midazolam group compared to diazepam group [5.25+/-0.86 minute vs 6.51+/-1.06 minute p. CONCLUSION: Midazolam by the intranasal route provides safe and equally effective non-invasive method of sedation for procedures and seizures.

Administration, Intranasal↗
PubMed2006

Effect of stimulation in coma.

OBJECTIVE: To find out efficacy and benefits of early starting of stimulation therapy in coma patients. DESIGN: Randomized controlled trial. METHOD: Sixty children admitted to the Department of Pediatrics, having coma due to non-traumatic neurological insult were randomly selected. Both study and control groups had 30 patients each. Children in the study group were given stimulation therapy while those in control group received no stimulation. The level of consciousness was assessed before and two weeks after giving stimulation therapy. RESULTS: Improvement in level of consciousness was better in study group as compared to control after two weeks of stimulation therapy. CONCLUSION: Stimulation therapy was found to be highly effective in coma patients.

Age Factors↗
PubMed2004

Health status of siblings of hospitalized children.

OBJECTIVE: To study health status of siblings of children hospitalized for various diseases. METHODS: A total of 308 siblings of 200 hospitalized children were studied by detailed history, anthropometry, physical examination and relevant laboratory tests. RESULTS: Only 43.83% siblings were fully immunized, 25.32% partially and 30.85% were totally unimmunized. Normal nutritional status was seen in 20.43% siblings; 26.95% had grade 1, 25.64% grade II, 24.02% grade III and 2.92% had grade IV malnutrition. Various morbid conditions were observed in siblings, the common ones were vit. A deficiency (22.40%), worm infestation (21.42%), anemia (19.15%), dental caries (13.63%), ARI (13.31%), diarrhoea (12.01%), malaria (7.46%) and scabies (7.14%). CONCLUSION: The siblings of hospitalized children are in a high-risk group as they share same environment and nutrition. They have various ailments in various stages of severity. The health screening of such children will have a positive impact in promoting health and diagnosing diseases at an early stage.

Adolescent↗
PubMed1997

Hepatoprotective activity of Boerhaavia diffusa L. roots--a popular Indian ethnomedicine.

The roots of Boerhaavia diffusa L., commonly known as 'Punarnava', are used by a large number of tribes in India for the treatment of various hepatic disorders. In the present study the effect of seasons, thickness of roots and form of dose (either aqueous or powder) were studied for their hepatoprotective action to prove the claims made by the different tribes of India. The hepatoprotective activity of roots of different diameters collected in three seasons, rainy, summer and winter, was examined in thioacetamide intoxicated rats. The results showed that an aqueous extract (2 ml/kg) of roots of diameter 1-3 cm, collected in the month of May (Summer), exhibited marked protection of a majority of serum parameters, i.e. GOT, GPT, ACP and ALP, but not GLDH and bilirubin, thereby suggesting the proper size and time of collection of B. diffusa L. roots for the most desirable results. Further, the studies also proved that the aqueous form of drug (2 ml/kg) administration has more hepatoprotective activity than the powder form; this is probably due to the better absorbtion of the liquid form through the intestinal tract.

Alanine Transaminase↗
PubMed1989

Toxicological consequences of chloroquine and ethanol on the developing fetus.

In the present study, the effects of chloroquine and ethanol administration during gestation have been investigated on the developing rat fetus. Intragastric administration of chloroquine (700 mg/kg body weight) resulted in several structural abnormalities. The incidence of hepatomegaly was increased by 30%, the liquification of visceral organs was increased by 15% and a 9% higher incidence of cleft palate, wrist drop, clubbed foot and brain liquification was observed in the fetuses from the chloroquine-treated group compared to the corresponding controls. Fetuses from the chloroquine-treated group also showed a decrease of about 40% in the body weight and a 30% reduction in the ossification of the sternum. The teratogenic effects of oral ethanol administration in several respects were similar to those of the chloroquine. Ethanol, when administered as 30% of the total daily calories, resulted in growth retardation, resorption, still births, liquification of the brain, wrist drop and clubbed foot. Additionally, ethanol resulted in the inhibition of several metabolic pathways in the liver and brain of the developing fetuses. This included the inhibition of protein, RNA and DNA metabolism in the fetal livers and brains. The feto-toxic effects of these two xenobiotics and their possible molecular mechanisms have been discussed.

Abnormalities, Drug-Induced↗
PubMed1981

Convenient synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester.

6-Nor-9,10-dihydrolysergic acid methyl ester (IV) was prepared by demethylation of 9,10-dihydrolysergic acid methyl ester (II) with 2,2,2-trichloroethyl chloroformate, followed by reduction of the intermediate carbamate (III) with zinc in acetic acid. The 6-ethyl-V and 6-n-propyl-VI derivatives were prepared by alkylation of IV with the appropriate halide. All of the ergoline derivatives were evaluated for stereotyped behavior in rats, with 6-nor-6-ethyl-9,10-dihydrolysergic acid methyl ester (V) being active but much less potent than apomorphine. Compound VI was evaluated for its effect on blood pressure; at a dose of 30 mg/kg ip, it significantly lowered, diastolic pressure in normotensive rats.

Animals↗
PubMed1980

Psychotropic drug metabolism in fetal alcohol syndrome.

Simultaneous intake of ethanol with chlorpromazine (thorazine), an antipsychotic drug, leads to about 60% decrease in the chlorpromazine removal from the rat blood. Studies with liver homogenates showed that ethanol inhibits the metabolism of this drug by about 50%. The inhibitory effect of ethanol on the metabolism of chlorpromazine can be largely abolished by pyrazole (2 mM) preincubation. Prolonged maternal ethanol consumption during pregnancy and lactation leads to a decrease in chlorpromazine metabolism in the fetal (30%), neonatal (46%) and maternal livers. Prolonged maternal ethanol intake also leads to an increase in the (UDPG)/(UDPGA) ratio in the suckling neonatal liver and the maternal liver. Simultaneous acute administration of ethanol (2g/kg) with psychotropic drugs such as chlordiazepoxide (librium), diazepam (valium), chlorpromazine (thorazine) or meprobamate (equanil) to pregnant or non-pregnant rats led to a decrease in the blood alcohol clearance rates. In another group of nonpsychotropic drugs tested, tolbutamide (orinase) produced the most pronounced (47%) decrease in blood alcohol clearance rates. This decrease was found to be accompanied by the inhibition of hepatic alcohol dehydrogenase.

Alcohol Oxidoreductases↗
PubMed1980

Development of histaminergic pathways in brain as influenced by maternal alcoholism.

The development of histaminergic pathways has been studied in the rat brain specially as influenced by maternal alcoholism. Maternal ethanol consumption during pregnancy results in an increase in the cerebral histamine levels of the fetus. An increase in the brain histamine levels is also observed in the newborn rats suckling on the ethanol-fed mothers compared to the corresponding controls. Brain histamine levels are highest towards latter part of the pregnancy and lowest in the adult brains, whereas the brain histidine decarboxylase activity is lowest in the fetal brains and highest in the adult brains. Maternal alcoholism either during gestation or during lactation did not significantly affect histidine decarboxylase activity in the fetal and neonatal brains. Acute administration of ethanol or acetaldehyde after 20 minutes resulted in significant increase in the brain histamine levels. This increase in the brain histamine levels seems to be a direct result of brain histamine release due to ethanol or acetaldehyde metabolism in the body. The effect of ethanol on brain histamine levels may have important implications inview of the fact that both histamine and ethanol influence diuresis, EEG activity, and thermoregulation in the body.

Acetaldehyde↗
PubMed1979

Inhibition of cardiac protein synthesis by prolonged ethanol administration.

Effects of prolonged ethanol consumption have been studied on the rates of cardiac protein synthesis. Prolonged ethanol consumption resulted in a significant decrease in cardiac contents of total protiens and RNA. Chronic exposure to ethanol did not result in an alteration in cardiac DNA content. The rates of protein synthesis measured by determining the rates of (U-14C)-leucine incorporation into cardiac proteins showed that chronic ethanol-feeding leads to a significant inhibition of protein synthesis. Studies with ribosomes and pH 5 enzyme fractions of heart showed that prolonged ethanol consumption inhibits the capacity of both these fractions to synthesize proteins. Acute administration of ethanol or in vitro addition of ethanol does not affect the cardiac protein synthesis in the heart. The acetaldehyde-mediated inhibition of cardiac protein synthesis can be partially prevented by antabuse. These observations suggest that, at least some of the deleterious effects of chronic ethanol consumption on the heart may be exerted through the inhibition of protein synthesis in the cardiac muscle.

Acetaldehyde↗
PubMed1978

Effects of maternal ethanol consumption on hepatic lipid biosynthesis in foetal and neonatal rats.

Effects of prolonged maternal ethanol consumption were studied on hepatic lipid content, on the rates of fatty acid synthesis and on the activities of enzymes involved in fatty acid synthesis in the livers of foetal and suckling neonatal rats. Prolonged maternal ethanol consumption resulted in a significant increase in the contents of hepatic total lipids, triacylglycerols and plasma unesterified fatty acids in foetal and neonatal rats. Studies in vitro with 3H2O showed that maternal ethanol consumption did not result in a significant change in its rate of incorporation into lipid fractions of foetal and neonatal livers. The rates of fatty acid synthesis showed a pronounced decrease immediately after birth, compared with the foetal stage, but increased in the adult animals. On the other hand, the highest rates of lipid oxidation were observed in the neonatal stage. Maternal ethanol consumption resulted in a significant decrease in the rates of [14C]palmitate oxidation to 14CO2 by both the foetal and neonatal livers. Maternal ethanol consumption did not result in an increase in the activities of any of the lipid-synthesizing enzymes tested throughout the period of development. Although increased fatty acid synthesis does not seem to be the mechanism for the accumulation of these lipids, decreased oxidation of the lipids may be partly responsible for the lipid accumulation.

Alcohol Drinking↗