A study of the plasma vitamin C concentration in patients in an assessment geriatric ward was carried out for 1 year. The incidence of vitamin C deficiency, as reflected by the plasma vitamin C level was 40.1%. There was almost no difference in its prevalence amongst the sexes or various age groups, but the incidence of vitamin C deficiency was highest in patients admitted from institutions. Furthermore, this study also revealed that patients with certain illnesses were more vulnerable to vitamin C deficiency than other patients and the standard hospital diet alone was not sufficient to improve the vitamin C status of these patients in the short-term.

Administration, Oral↗

PubMedDate not supplied

Cultured lung cells: effects of isotopic dilution and some undefined stimulation on the incorporation of radiolabeled palmitate and choline into phosphatidyl choline (lecithin).

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Animals↗

PubMedDate not supplied

Cultured lung cells: interplay effects of beta-mimetics, prostaglandins and corticosteroids in the biosynthesis of dipalmitoyl lecithin.

Cell lines derived from type II lung cells were used to study interplays of substances affecting incorporation of labeled precursors [1(-14)C]palmitate and [methyl-3H]choline into phosphatidyl choline. Ethanol stimulated markedly biosynthesis of dipalmitoyl phosphatidyl choline in cloned rabbit lung cells; the stimulating action of ethanol was reduced very much by cortisol and less by ritodrine. In the presence of 0.1 microM isoproterenol, two prostaglandins, E2 and F2alpha, caused marked depressions in the incorporation of both precursors by cell line A 549 derived from human lung adenocarcinoma. One concluded that among the agents studied, ethanol and cortisol are potent antagonists, and so were also the prostaglandins and isoproterenol.

Animals↗

PubMedDate not supplied

Cerebral oedema and blood-brain and blood-CSF barriers in experimental brain trauma: effect of indomethacin-A prostaglandin synthetase inhibitor.

Cerebral oedema often occurs following trauma to the brain. Recently several biogenic amines have been suggested for their possible mediation in the pathophysiology of traumatic brain oedema. The present investigation indirectly indicates that prostaglandins of E series are also involved in the etiology of cerebral oedema, since administration of a potent PG synthetase inhibitor, indomethacin significantly diminished oedematous swelling of traumatised rat brain.

Animals↗

PubMedDate not supplied

Anterior cerebellum as a site for morphine analgesia and post-stimulation analgesia.

The microinjection of 10 micrograms Morphine into culmen region of anterior cerebellum produced profound analgesia in rats, and this was antagonised with intraperitoneal administration of naloxone. On the other hand, the same injection of morphine into lobus simplex and declive region of posterior cerebellum was without any effect on nociception. Further it was observed that chronic surgical ablation of culmen-centralis region of anterior cerebellum markedly diminished the duration of analgesia elicited with systemic administration of morphine, though ablation per se had no influence on nociception. Also, the focal electrical stimulation of culmen region for brief period exhibited post-stimulation analgesia. These findings indicate that anterior cerebellum specifically plays some role in the modulation of physiological mechanisms of pain relief.

Animals↗