[Pharmacological properties of the methylamide of N-(4-antipyril)-oxaminic acid (oxapyrine)].
Comparative results of a pharmacological study on amidopyrine and a new original drug--N-(4-antipyril)-oxaminic methylamide are reported. Investigations conducted on animals showed the anodyne action of amidopyrine to manifest itself in toxic doses. This drug has a direct depressing effect on an isolated heart, a length of the intestine and the uretus of test animals. When employed in experimental conditions N-(4-antipyril) oxaminic methylamide displayed a much greater analgesic action that did amidipyrine. The drug has low toxicity both with its single and systemic introduction for a period of 60 days and it produces no inhibitory effect on isolated smooth muscle organs. It is concluded that the advantages of the newly synthetized agent come as a result of purposefully made structural changes in the formula, viz by introduction of a hydrazine group and of an oxaminic radical in the side chain.