Betamethasone valerate aerosol given in doses of 100 mug into each nostril twice daily was compared with a placebo in a double-blind, cross-over trial involving thirty patients with seasonal rhinitis. Patients recorded symptoms of eye irritation and watering, sneezing, rhinorrhoea, and nasal blockage, on a diary card. Analysis of the symptom scores showed that nasal symptoms were significantly better on betamethasone valerate than on placebo (P less than 0.01) and that nasal blockage in particular was improved (P less than 0.001). The patients' preference was significantly in favour of the active compound (p less than 0.02) and no side-effects were noted. It is concluded that betamethasone valerate offers a safe and effective form of treatment for seasonal rhinitis.

Administration, Intranasal↗

PubMed1975

Antibacterial activity of some newly synthesized azaphenanthrene and diazachrysene compounds.

Four newly synthesized azaphenanthrene compounds viz., 7,8,9,10-Tetrahydro-7-oxo-2-methoxy-benzo(c) phenathridine; 7,8,9,10-Tetrahydro -7-oxo-benzo(c) phenanthridine-2-[1-6-methoxy-1-naphthylimino)-methyl]cyclohexane-1,3-dione and 2-[1-(1-naphthyli; mino)-methyl]cyclohexane-1,3 dione and two diazachrysene compounds viz., 1,5-Diazachrysene and 2,5-Diazachrysese were screened for their antibacterial potency against a large number of bacterial strains. The antibacterial activity which to a varying degree was shown to be related to the aza, methoxy and keto groups, in the case of the Azaphenanthrene compounds, however, it was related to the position of the nitrogen atom in the ring in the case of Diazachrysene compounds.

Anti-Bacterial Agents↗

PubMedDate not supplied

A double-blind comparison of a microcrystalline theophylline tablet and salbutamol in reversible airways obstruction.

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Adult↗