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Biomedical subjects

A Köling

Publications and source records attributed to A Köling.

22 records · Page 2Linked to original sources

The blood capillaries in the subodontoblastic region of the human dental pulp, as demonstrated by freeze-fracturing.

The microvasculature of the subodontoblastic region in the human dental pulp was studied, using freeze-fracturing. This technique allows an analysis of the fine structure of the vascular endothelium with special reference to the membrane structure. The blood capillaries were noted to be of the non-fenestrated or continuous type, although a few fenestrated vessels were observed. The endothelial plasmalemma often exhibited bundles of fibrillar structures, presumably myofilaments. There was a relatively large number of micropinocytotic vesicles and the interendothelial spaces were closed juxtaluminally by tight junctions (zonulae occludentes). The junctions appeared mostly as two to four strands, seen as ridges or grooves on the cell membrane. Thin-walled, irregular, tissue channels lacking the typical, blood-vessel configuration were disclosed. These vessels were believed to represent lymphatics.

Capillaries↗

A freeze-fracture study of receptor axons and Schwann cells in the human olfactory mucosa.

Electron micrographs of freeze-fracture replicas from the human olfactory mucosa were analysed regarding the structure of the axons of the olfactory receptor cells. In the lamina propria, numerous axons were generally invested with one Schwann cell. The ensheathed axons were often found in close contact with one another. Membrane specializations were not found at these sites, nor were tightening membrane junctions observed in the mesaxons. The Schwann cell plasmalemma exhibited caveolae, whose neck was surrounded by uniformly sized intramembranous particles evenly distributed over the axolemmal fracture planes. There was a marked difference in particle density between the P face (about 850/micron 2) and the E face (about 180/micron 2).

Axons↗

The effect of ipratropium bromide on nasal hypersecretion induced by methacholine in patients with vasomotor rhinitis. A double-blind, cross-over, placebo-controlled and randomized dose-response study.

The effect of various doses of ipratropium bromide aerosol on nasal hypersecretion induced by five concentrations methacholine was studied in 24 patients with vasomotor rhinitis and excessive watery nasal secretion. The volume of nasal secretion was greater with each of the five increasing doses of methacholine from 7.5 to 120 mg/ml. The median volume of nasal secretion was alike in all patients after administration of methacholine only and after treatment by placebo followed by methacholine. When the patients were treated with ipratropium bromide prior to administering methacholine the volume of secretion was reduced significantly. With doses of 40 micrograms and 100 micrograms of ipratropium to each nostril a similar reduction in the volume of secretion occurred but a still greater reduction by the application of 200 micrograms of ipratropium when compared with treatment by the placebo. While the volume of secretion increased with each increasing concentration of methacholine, a similar pattern of reduced secretion for each concentration of methacholine was seen with each greater concentration of ipratropium. In patients with vasomotor rhinitis, treatment with ipratropium bromide was found to reduce significantly the hypersecretion induced by methacholine when compared with treatment by the placebo. This reduction was greater with greater doses of ipratropium.

Administration, Inhalation↗