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Biomedical subjects

A Künzler

Publications and source records attributed to A Künzler.

7 recordsLinked to original sources
PubMed1992

[Pathological changes in face and skull in acromegaly].

31 patients (mean age 52.7 years) suffering from persistent symptoms of a growth hormone producing pituitary adenoma underwent both clinical and roentgenological examinations. The results of standardized x-ray analysis of the viscero- and neurocranium were compared with those of a group of 25 healthy subjects (mean age 42.1 years): Although several remarkable changes were observed, statistically significant changes of the facial skeleton could be found only in the lower jaw. The main contribution to its elongation was given by the chin prominence and the condyle. The findings in the neurocranium could be divided in symptoms of first and symptoms of second choice. With the help of these parameters, a score was established to facilitate interpretation of early signs of acromegaly in lateral skull radiographs. Two clinical symptoms found in our patient sample have not been mentioned before in literature about acromegaly: the so-called "hanging columella" and marked changes in diameter of the canalis mandibularis.

Acromegaly↗
PubMed1991

Typical changes in the viscerocranium in acromegaly.

31 patients (mean age 52.7 years) suffering from persistent symptoms of a growth hormone-producing pituitary adenoma underwent both clinical and radiological examination at least one year after transnasal extirpation of the tumour. The results of standardized X-ray analysis of the viscerocranium were compared with a group of 21 healthy subjects (mean age 42.1 years): Although several remarkable changes of the facial skeleton were observed, statistically significant changes could be found in the lower jaw only. The ascending ramus as well as the mandibular body were found to be elongated. The main contribution to the elongation was made by the chin prominence and the condyle. Two different growth patterns of the mandible could be determined; neither of them was pathognomonic for acromegaly. Due to overgrowth of the septal cartilage in 7 patients we found a so-called "hanging columella". In 16 patients the mandibular canal was widened and showed marked deviations in its diameter or a funnel-shaped mandibular foramen.

Acromegaly↗
PubMed1981

[Rhythm disorders in the rehabilitation phase after myocardial infarct].

45 patients with uncomplicated myocardial infarction and on no cardiac drugs underwent an exercise test and 24-hour monitoring 53 (range 22-80) days after the acute event before entering a 4-week rehabilitation program. These same tests were repeated 21 days later. Severe ventricular arrhythmias were registered in 14 patients (31%) while monitored on tape, in only 1 patient during exercise. Arrhythmias were more common in patients with ST-depression during exercise (38%) and in patients with reduced work capacity (42%). Non-smokers had no severe arrhythmias. The rehabilitation program had no influence on these findings. Arrhythmias after myocardial infarction correlate with work capacity and myocardial ischemia.

Adult↗
PubMed1979

Cytomegalovirus strain differentiation by DNA restriction analysis.

The heterogeneity of CMV DNA obtained from standard strains and new isolates, including a vaccination strain (Towne 125), was investigated. The cleavage patterns produced by the restriction endonucleases Eco RI and Bam 1 revealed stable strain specificities of CMV. On the other hand, a remarkable homology of sequence-specific CMV DNA fragmentation was demonstrated. A CMV subtyping relevant to clinical questions seems to be improbable.

Antigens, Viral↗