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A Kadner

Publications and source records attributed to A Kadner.

23 records · Page 2Linked to original sources
PubMedDate not supplied

[Inpatient and follow-up nosocomial wound infection in orthopedics].

SUBJECT: This study was designed to determine if direct documentation (in-patients) and questionnaire (out-patients) are reliable follow-up methods to record nosocomial wound infections (NWI) after orthopedic surgery. Furthermore if postdischarge NWI were also detected without this project. MATERIAL AND METHODS: 1664 patients after orthopedic surgery were evaluated over 20 month. In-hospital infections were directly documented. Later infections were recorded by questionnaire 3 months following patient's discharge. Data of all cases with NWI were retrospectively evaluated as a control. RESULTS: A total of 18 NWI (1.1%) were recorded. 2 of these were deep wound infections after hip or knee arthroplasty, no re-operation was required. 6 NWI (33.3%) occurred after discharge. All of these post-discharge NWI were detected in our out-patient clinics. CONCLUSION: This study demonstrate, that postoperative wound infections surveillance must be continued after discharge. 33.3% NWI occurred after discharge and all cases were detected at our out-patient clinics. We conclude that questionnaires to record post-discharge NWI are not necessary in hospitals with routinely follow-up in out-patient clinics.

Adolescent↗
PubMedDate not supplied

Trained discrimination of temporal patterns: cochlear implants in gerbils.

The purpose of this study was to establish an animal model for the discrimination of temporal order cues contained in electrical stimuli to the cochlea. Gerbils were deafened and implanted in the right cochlea with a single platinum stimulating electrode. Two groups of animals were trained in a two-way active avoidance shuttle box paradigm to discriminate downward from upward interval-modulated pulse trains (1-100 ms). One group consisted of naive animals. The other group had previously been trained in the same shuttle box (same behavioral meaning) to discriminate identical pulse trains presented acoustically. Significant discrimination performance was found in the group of naive animals. However, over the 6-day training period, animals with previous acoustic experience achieved no significant discrimination performance. This suggests that temporal order cues in pulse trains can be used in cochlear implants to transmit behaviorally relevant information but that this may be in conflict with relevant auditory preexperience.

Animals↗
PubMedDate not supplied

Heat shock protein upregulation lowers cytokine levels after ischemia and reperfusion.

OBJECTIVE: Studies showed that the expression of heat shock protein 70 (HSP70) by whole-body hyperthermia or warming of the heart is associated with protection against ischemia/reperfusion injury. The aim of this study is to determine a time-related response of HSP70 expression through topical cardiac warming with correlation to cytokine production. METHODS: 30 rats were divided into three groups: no heat shock, heat shocked, and controls. Heat shock was performed with 42 degrees C saline solution applied to the heart for 5, 30, and 60 min. HSP70 and cytokines were measured. RESULTS: Heat shock treated animals showed a 1.2-fold increase after 5 min (NS) in HSP70 expression, a 2.0-fold increase (p < 0.02) after 30 min, and a 2.3-fold increase (p < 0.012) after 60 min compared to controls. The IL-1beta levels decreased from 14.3 pg/ml (normal controls) to 7.1 pg/ml after 5 min, to 1.6 pg/ml after 30 min (p < 0.002), and to 1.4 pg/ ml after 60 min of heat shock treatment (p < 0.002). The TNF-alpha levels also decreased, but not significantly. CONCLUSIONS: Upregulation of HSP70 through this novel method is instant and detectable within hours. The amount of HSP70 expression induced is time dependent, showing an indirect correlation with cytokine levels. These results suggest that the protective effect of HSP70 is immediate and might be explained by reduced cytokine levels. No prior recovery period is needed.

Animals↗