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Biomedical subjects

A Kafatos

Publications and source records attributed to A Kafatos.

At least 55 records · Page 3Linked to original sources
PubMed1998

Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2.

OBJECTIVE: The purpose of the present study was to investigate the relation state and trait anxiety and adipose tissue essential fatty acid precursors for prostaglandins E1 and E2. METHODS: The sample consisted of 144 male and female Cretan adults, 23 to 69 years of age. Anthropometric and arterial blood pressure measurements were taken, and adipose tissue samples as well as data concerning general health habits were collected. Dietary data were collected using the weekly food frequency questionnaire and the 24-hour dietary recall method, while state and trait anxiety was assessed through the use of the Spielberger State-Trait Anxiety Inventory (STAI) and the Zung anxiety scale. RESULTS: State anxiety (STAI) related positively with sex (p < 0.0003) and negatively with adipose fat myristic acid (C14:0) (p < 0.004). Similarly, Zung trait anxiety related positively with sex (p < 0.0001) and negatively with adipose tissue myristic acid (C14:0) (p < 0.04). Spielberger trait anxiety related positively with adipose (LA + ALA)/(AA + EPA) ratio (p < 0.0002) and negatively with (C14:0) (p < 0.02) and dietary monounsaturated fat (p < 0.03). CONCLUSION: It appears that the positive relation between trait anxiety and adipose (LA + ALA)/(AA + EPA) ratio may stem from the inhibiting role of catecholamines on delta 6 and delta 5 desaturases.

Adipose Tissue↗
PubMed1998

Effect of long-term olive oil dietary intervention on postprandial triacylglycerol and factor VII metabolism.

Although the beneficial effects of Mediterranean-type diets, which are rich in olive oil, a good source of monounsaturated fatty acids (MUFAs), are generally accepted, little is known about the effects of long-term dietary MUFA intake on postprandial lipoprotein metabolism and hemostasis. This study used a single-blind, randomized, crossover design to investigate the relative effects of a long-term dietary olive oil intervention and a control [saturated fatty acid (SFA)-enriched] diet on postprandial triacylglycerol metabolism and factor VII activity. The postprandial response to a standard test meal was investigated in 23 healthy men who adhered to both diets for 8 wk. cis-MUFAs were successfully substituted for SFAs in the MUFA diet without affecting total dietary fat or energy intakes. The long-term dietary MUFA intervention significantly reduced plasma and LDL-cholesterol concentrations (P = 0.01). Postprandial triacylglycerol concentrations were significantly greater in the early postprandial period after the MUFA diet (P = 0.003). Postprandial factor VII activation and the concentration of the factor VII antigen were significantly lower after the MUFA diet (P = 0.04 and P = 0.006, respectively). This study showed that isoenergetic substitution of MUFAs for SFAs reduces plasma cholesterol and reduces the degree of postprandial factor VII activation. The alterations in the postprandial triacylglycerol response suggest a greater rate of dietary fat absorption and postprandial triacylglycerol metabolism after a diet rich in MUFAs. This study presents new insights into the biochemical basis of the beneficial effects associated with long-term dietary MUFA consumption, which may explain the lower rates of coronary mortality in Mediterranean regions.

Adult↗
PubMed1998

The effects of a health education intervention initiated at first grade over a 3 year period: physical activity and fitness indices.

A health education intervention was carried out for three consecutive years on primary school Cretan children. Baseline measures were obtained from 962 pupils (509 boys and 453 girls) registered in first grade in 1992. The health education intervention programme was directed at both the children of the intervention group and their parents, and has a projected duration of 6 years. After the completion of the 3 years of intervention and while pupils were in fourth grade, measures were obtained for evaluation purposes on a random subsample of 393 pupils of the original cohort. Statistically greater improvements in the intervention, as opposed to the control group, were observed for both children's and parents' health knowledge, and children's standing broad jump, sit-ups (SUP), sit-and-reach, handgrip and endurance run test (ERT). Furthermore, time spent on moderate to vigorous physical activities out of school significantly increased for intervention group children compared to the control group. Statistically smaller increases in the intervention as opposed to the control group were observed in suprailiac skinfold and body mass index. The degree of improvement in both SUP and ERT related positively to parent's baseline physical activity score. Finally, the parental attitude of health-related hedonism related negatively to SUP improvement.

Child↗
PubMed1997

Antibiotics prescription for indigent patients in primary care.

OBJECTIVE: A drug use evaluation focusing on prescribed antibiotics among Greek indigent and Social Security patients. METHOD: Four hundred and forty-six indigent patients insured by Social Care and 332 patients insured under Social Security Funds were interviewed and their prescription records reviewed. RESULTS: Although 88.5% of indigent patients stated that they had received instructions on antibiotic use and had understood these instructions, only 45.9% could correctly repeat these instructions. Only 9.9% read the enclosed leaflets and 59.4% reported asking the pharmacist for advice, 54.1% of these patients were unaware of the dosage of their medication, and the length of treatment was only written in 13% of cases. The most common diseases among indigent patients were respiratory infection (11.7%) and dental problems (10.1%). The latter ranked 11th among the insured patients (3.7%). Tuberculosis (3.3%) was still one of the most common diseases among the indigent patients. Overall, 30.9% of the prescribed daily defined dose (DDD) of medication for the indigent patients were for cardiovascular drugs (16.9% of the cost), 19.5% were for nervous system drugs (8.9% of the cost), 13.5% for gastrointestinal tract drugs (14.1% of the cost) and only 4.3% were antibiotics (but 16.9% of the cost). The most frequently prescribed antimicrobials were penicillins (45.6%), cephalosporins (19.7%), macrolides (12.6%) and quinolones (9.6%). Antituberculous agents made up 13.7% of the antibiotic prescriptions. The most widely prescribed antibiotics were amoxycillin + clavulanate (19.3%), amoxycillin (7.9%), cefaclor (5.6%), clarythromycin (5.1%) and rifampicin + isoniazid (6.3%). CONCLUSION: The present study emphasizes the need for more information on drug use among indigent patients and their information needs.

Adolescent↗
PubMed1997

Heart disease risk-factor status and dietary changes in the Cretan population over the past 30 y: the Seven Countries Study.

A follow-up study was conducted to identify the heart disease risk-factor status and dietary changes of surviving elderly subjects in Crete who took part in the Seven Countries Study in 1960. In 1991, data were obtained from 245 of the 686 original male participants (169 of the original 40-49-y age group and 76 men 50-59 y age group). In 1991, the men were 70-79 and 80-89 y old. There was a significant (11.5%) increase in serum total cholesterol concentrations between 1960 and 1991. Body mass index and systolic and diastolic blood pressures also increased significantly, and all age groups were characterized by central obesity. A representative subsample of 21 men took part in a 3-d weighed food record study. Dietary data indicated increases in the intake of saturated fat and decreases in monounsaturated fat over the 30-y period. Comparison with a 1962 representative Cretan sample indicated a significantly increased concentration of adipose palmitic acid (16:0) in our surviving sample. The observed changes occurred during a period when many developed countries were observing a decline in most heart disease risk factors.

Adipose Tissue↗
PubMed1997

Sources used and trusted by nationally-representative adults in the European Union for information on healthy eating.

OBJECTIVE: To assess what sources of information on healthy eating are used and in particular to ascertain which are the most trusted by European adults. DESIGN: A cross-sectional study in which quota-controlled, nationally-representative samples of approximately 1000 adults from each country completed a face-to-face interview-assisted questionnaire. SETTING: The survey was conducted between October 1995 and February 1996 in the 15 member states of the European Union. SUBJECTS: 14331 subjects (aged 15 y upwards) completed the questionnaire. Data were weighted by population size for each country and by sex, age and regional distribution within each member state. RESULTS: The five sources of information most frequently selected were: TV/radio (29%), magazines and newspapers (27%), health professionals (26%), food packages (22%) and relatives/friends (22%). Those used by less than 5% of the population included vegetarian and slimming societies and women's organizations. The reliance on health professionals for information was stronger for females and tended to increase with age. The most trusted sources of information in almost all countries were health professionals (91%) and government agencies (80%) with great consistency across countries. 15% of Europeans stated that they did not get any information on healthy eating.

Adolescent↗
PubMed1997

Stages of dietary change among nationally-representative samples of adults in the European Union.

OBJECTIVE: To investigate the distribution across the different stages of change for each of the 15 participating European countries, and the effect of socio-demographic variables such as sex and education on this distribution. Also to assess the relationships between stages of change and influences of food choice, and other variables. DESIGN: A cross-sectional study in which quota-controlled, nationally-representative samples of approximately 1000 adults from each country completed a face-to-face interview-assisted questionnaire. SETTING: The survey was conducted between October 1995 and February 1996 in the 15 member states of the European Union. SUBJECTS: 14331 subjects (aged 15 y upwards) completed the questionnaire. Data were weighted by population size for each country and by sex, age and regional distribution within each member state. Subjects were divided into five different categories according to their attitudes towards 'changing their eating habits in order to eat healthier': (1) Precontemplation; do not consider any changes, (2) Contemplation; consider changes, (3) Decision; make plans to change, (4) Action; carry out the changes, and (5) Maintenance; maintained changes for more than six months. RESULTS: 52% of the subjects were in the precontemplation stage, whereas 31% of the subjects were in the maintenance stage. Two, one, and seven percent of subjects were in the contemplation, decision and action stage, respectively. In the Mediterranean countries, and in Germany, there were more people (55-64%) in the precontemplation stage, whereas in the Scandinavian countries there were less people in precontemplation stage (20-38%). The opposite was true for the maintenance stage, whereas women and people with a higher education level tended to be more in the maintenance stage. With respect to influence on food choice, subjects in precontemplation stage found that taste was more important, whereas people in maintenance stage found that health was more important. CONCLUSIONS: The stages of change model makes a useful distinction between people with different attitudes towards nutrition and health. Nutrition education can benefit from this distinction.

Adolescent↗
PubMed1996

Prescribed medication and nutrition of social care patients in Crete, Greece.

OBJECTIVE: The aim of this study was to make a systematic registration of a group of 354 social care indigent patients in relation to: their pharmaceutical needs: the conditions for which it was prescribed, its cost, and details of prescriptions. In addition patients' eating patterns relating to and knowledge of how to use their medication was assessed. They were compared to a control group of 153 Social Security patients. SUBJECTS: The Social Care indigent patients were of low income, consisting of groups as unmarried mothers with their children and Greeks emigrants coming back home from other countries (Albania, Russia, Georgia, Ukraine, Romania etc.). The socio-demographic profiles of this group reveal an unemployment rate of 74% and an illiteracy rate of 18%. As regards marital status, 20% are bachelors and 12% divorcees. RESULTS: The results of the study indicated no significant difference between the two groups in the mean cost of prescription (40 ECU for Social Care patients vs 32 ECU for Social Security patients), in the mean number of medication per prescription (2.6 vs 2.6 respectively), in the percentages of the Daily Defined Doses and the cost of the various categories of drugs. For both groups, the most common drugs were those of the Cardiovascular system (30% vs 26%), Gastrointestinal system (17% vs 27%) and Nervous system (16% vs 18%). The most common diagnosis was Hypertension (10% vs 8%) and the most common drugs were Ranitidine (3% vs 2%), Diclofenac (3% vs 3%), Salbutamol (3% vs 3%) and Paracetamol (2% vs 2%). Significant differences between Social Care patients to Social Security patients respectively were found regarding: knowing how to take their medication correctly (47% vs 77%), knowing for how long treatment needed to be taken (21% vs 43%), requesting information from the pharmacist (39% vs 68%) knowledge of dietary instructions regarding medication (17% vs 41%) and in smoking more than 20 cigarettes per day (15% vs 3%). CONCLUSIONS: The results indicated that the Social Care patients, in comparison with the patients of the Social Security, need more education and more help in the area of the proper use of drugs and in the personal contact that this procedure involves.

Adolescent↗
PubMed1996

Changing prevalence of coronary heart disease risk factors and cardiovascular diseases in men of a rural area of Crete from 1960 to 1991.

This study compares the prevalence of coronary heart disease (CHD), risk factors (RF), and cardiovascular diseases (CVD) among Cretan men from a rural area examined in 1960 and 1991. The study population consisted of 148 men in 1960 and 42 men in 1991 of the same age group (fifty-five to fifty-nine years old) and from the same rural area. All men had a complete examination of the cardiovascular system and a resting electrocardiogram (ECG). Systolic BP (SBP) > or = 140 mmHg was found in 42.6% of the subjects in 1960 and in 45.2% in 1991 (NS). Diastolic BP > or = 95 mmHG was found in 14.9% of the subjects in 1960 as opposed to 33.3% in 1991 (P < 0.02). Total serum cholesterol (TSCH) > or = 260 mg/dL approximately 6.7 mmol/L) was found in 12.8% of the subjects in 1960 and in 28.6% in 1991 (P < 0.01). Heavy smokers ( > or = 20 cigarettes/daily) were 27.0% in 1960 as compared with 35.7% in 1991 (:NS); 5.4% of the subjects in 1960 had light physical activity (PA) as compared with 14.3% in 1991 (P < 0.01); 74.7% of the subjects were farmers in 1960 as compared with 43.6% in 1991 (P < 0.1). The prevalence of CHD was 0.7% in 1960 as compared with 9.5% in 1991 (P < 0.001). Hypertensive heart disease was found in 3.4% of the subjects in 1960 and 4.8% in 1991 (NS). The prevalence of all major CVD was much higher in 1991 (19.1%) as compared with 1960 (8.8%) (P < 0.01). In conclusion, the prevalence of CHD RF and CVD was much higher in 1991 than in 1960 for Cretan men of the same age group. This higher prevalence seems to be related to dietary and life-style changes that have taken place in Crete during the last thirty years.

Cardiovascular Diseases↗
PubMed1996

Dietary vitamin E intake and plasma tocopherol levels of a group of adolescents from Spili, Crete.

Vitamin E is a very important nutrient in the human diet mainly due to its antioxidant properties. In this study an attempt was made to measure and evaluate vitamin E intake and to determine plasma tocopherol levels in a group of adolescents in Spili, Crete, Greece. It is known that Crete is an area with a high consumption of olive oil. It has been shown in this study that the mean olive oil consumption of these adolescents was 70.7 +/- 15.4 g/day. Vitamin E intake was 11.7 +/- 2.3 mg/day and olive oil provided 67% of this intake. Furthermore the vitamin E/PUFA ratio in food intake was 1.5 mg/g a value higher than reported by other investigators for populations with a high consumption of seed oils. The mean serum a-tocopherol levels in the selected 12 adolescents was 0.79 mg/dl (range 0.7-1.02).

Adolescent↗
PubMed1996

Prevalence of obesity in Greece.

The purpose of the present study is the presentation of the available literature on obesity in Greece. The heterogeneity of design, small sample size and limited number of studies conducted, complicates the delineation of definite trends. Nevertheless, the existing literature appears to point at a high prevalence of obesity among Greek children. Childhood obesity, may partly be accounted for by the over-protection and forced feeding by Greek parents. With regard to the incidence of obesity among Greek adolescents, studies have yielded controversial results. On the other hand, the existing evidence appears to indicate a high prevalence of obesity among Greek adults and the elderly, particularly those above 30 years of age. In contrast to the females, males appear to be characterised by central obesity. These observations highlight a need for primary prevention measures.

Adolescent↗
PubMed1995

The seroprevalence of ten zoonoses in two villages of Crete, Greece.

The seroprevalence and incidence of 10 zoonoses due to Rickettsia typhi, R. conorii, Coxiella burnetii, Burcella sp., Borrelia sp., Toxoplasma sp., Leishmania sp., Entamoeba histolytica, Echinococcus granulosus and Fasciola hepatica were studied in an animal husbandry and a farming village in Crete, Greece. The serum conversion incidence of each infectious agent was determined by testing 2 blood samples, collected in 1985 and in 1987. The surveillance was conducted using detailed transparent maps of the 2 villages studied, on which epidemiological data were interrelated to the results obtained from the serological tests. Thus the importance and spread of each infection were visualized. C. burnetii, Toxoplasma sp., R. conorii, and E. granulosus, were the most common infectious agents encountered during this study.

Adult↗
PubMed1994

Type A behavior and adipose tissue linoleic acid: implications for stress management.

OBJECTIVE: The purpose of the present study was to investigate the relation between Type A behavior and adipose tissue linoleic acid composition. METHODS: The sample consisted of 73 male and female Cretan adults, 23-64 years of age. Anthropometric and arterial blood pressure measurements were taken. Adipose tissue samples were collected by aspiration and data concerning general health habits were obtained. Food intake was estimated by a 24-hour dietary recall, while Type A profile was assessed with a Greek translation of the Bortner scale. RESULTS: Factors associated with Type A profile are adipose tissue linoleic acid (p < 0.0004), annual income (p < 0.001), total serum cholesterol (p < 0.009), and adipose fat myristoleic acid (p < 0.02). Negative correlations were observed between adipose linoleic and myristoleic acids and the dependent variable. CONCLUSION: It appears that adipose tissue linoleic acid may be one of the etiological factors for Type A behavior in adults.

Adipose Tissue↗
PubMed1993

Nutrition status of the elderly in Anogia, Crete, Greece.

General health and nutritional status of 167 free-living elderly Greek (aged 65-91 years) were assessed. The most prevalent diseases/symptoms encountered were related to respiratory, gastrointestinal, musculoskeletal and vascular systems (hypertension). Most subjects were socially active. Body mass index was < 20 and > 25 Kg/m2 in 7 and 57% of the subjects, respectively. Systolic blood pressure was significantly higher in women than in men, and as a group, 18 and 42%, respectively, had diastolic blood pressures > 90 and systolic blood pressures > 160 mmHg. Anemia and hypoalbuminemia were detected in < 5% of the population. Total fat intake was 40-45% of total energy intake and most of it came from monounsaturated fat. Hypercholesterolemia (> 6 mmol/L) was present in 32% of subjects. The percentages of men who smoked (66%) or drank (68%) were significantly higher than those of women (2 and 1%, respectively). Dietary intake data were compared with US recommended dietary allowances (RDA) for elderly. Daily energy and protein intakes were lower than the US RDA levels; calcium intake was > 50% of the US RDA, while magnesium and vitamin B6 levels were < 50% of the US RDA. Vitamin C intake was much higher than that of the US RDA. Mean thiamin, vitamin A, riboflavin and iron intakes were below the US RDA, while fiber intake was < 50% of the corresponding US estimate. Phosphorus was higher than the US RDA in men, while lower for women. Sodium intakes exceeded those recommended, while potassium levels were higher than those recommended in males, and lower in females.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1993

Alcohol, tobacco, and father's aggressive behavior in relation to socioeconomic variables in Cretan low versus medium income families.

In order to identify socioeconomic factors affecting parents' alcohol and cigarette consumption and father's aggressiveness toward other family members, 87 low-income and 92 medium-income Greek families were tested. Father's alcohol consumption correlated positively with his smoking (p < .0008) and aggressive behavior (p < .00005), while mother's alcohol correlated positively with her smoking (p < .0001) and number of marriages (p < .01), and negatively with the family's overcrowding index (p < .006). Furthermore, father's smoking correlated positively with his alcohol (p < .01), and mother's smoking with her alcohol (p < .0004) and tenancy (p < .01). Finally, father's aggressiveness was found to be positively related to his alcohol consumption and negatively to his work and level of education.

Adult↗
PubMed1991

The effects of a health education intervention program among Cretan adolescents.

BACKGROUND: An educational intervention program for the prevention of cardiovascular disease among 171 Cretan school students (13- and 14-year-olds) is assessed. Three schools from the province of Agios Vassilios acted as the intervention group while two schools from a neighboring province (Amari) formed the control group. METHODS: Variables measured included: systolic and diastolic blood pressures, body mass index, triceps skinfold thickness, serum total and high-density lipoprotein cholesterol, triglycerides, and smoking habits. The intervention, based upon social learning theory, consisted of 10 sessions of theoretical and practical instruction on health issues in the classroom, supplemented with discussion, in the classroom, of the issues raised by different sessions. RESULTS: At the end of 1 academic year of intervention the results showed, after adjusting for age, sex, baseline value, height, and weight, an increase in total serum cholesterol of 0.70 mg/dl in the intervention group and 17.91 mg/dl in the control group (P less than 0.0001). Diastolic blood pressure (fourth phase) decreased by 2.95 mm Hg in the intervention group and by 0.48 mm Hg in the control group (P less than 0.05). Similar changes were observed in the body mass index (P less than 0.05). The proportion of school children starting smoking was significantly lower in the intervention group (6%) than in the control (20%) (P less than 0.01). The results indicate that this health education program in schools is effective in decreasing some of the major CVD risk factors. The long-term effect remains to be evaluated.

Adolescent↗