Neonatal cardiac rhabdomyoma.
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Fatal Outcome↗
Biomedical subjects
A Kalgutkar
Publications and source records attributed to A Kalgutkar.
Papillomatosis of the gallbladder in metachromatic leukodystrophy.
A 2-year-old boy who presented with a cystic gallbladder mass was found histologically to have metachromatic leukodystrophy. Diffuse hyperplasia of the gallbladder mucosa, multiple tendrillar fronds extending into the lumen, extensive papillomatosis, and the presence of large numbers of macrophages bearing metachromatic material confirmed the diagnosis. The child developed progressive degeneration of the central nervous system, refractory bronchopneumonia, and generalized muscular atrophy. A computed tomographic scan of the brain demonstrated hypodense areas of white matter suggestive of demyelination. This report describes the rare association of gallbladder papillomatosis with a storage disorder and reviews the relevant literature.
Child, Preschool↗
Nonmidline yolk sac tumour of the head and neck region in an infant with Dandy Walker syndrome--case report and review of literature.
Germ cell neoplasms are among the most commonly observed tumors in the pediatric age group. However, yolk sac tumors, which form a common subtype occur rarely in the head and neck region. In this paper we share our experience of one such rare case and review the literature about this condition.
Antineoplastic Combined Chemotherapy Protocols↗
Primary adenocarcinoma of the jejunum masquerading as abdominal tuberculosis.
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Adenocarcinoma↗
Congenital primary cerebral neuroblastoma.
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Adult↗
Chylous mesenteric cyst: an unusual cause of neonatal intestinal obstruction.
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Chylous Ascites↗
Glycogen storage disease type IIa.
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Biopsy, Needle↗
Mechanistic studies on the monoamine oxidase B catalyzed oxidation of 1,4-disubstituted tetrahydropyridines.
Previous studies have established that 1-cyclopropyl-4-phenyl-1,2,3,6- tetrahydropyridine (6) is an efficient time and concentration dependent inhibitor of the flavin containing enzyme monoamine oxidase B (MAO-B). This behavior is consistent with a proposed mechanism based inactivation pathway initiated by transfer of one of the nitrogen nonbonding pairs of electrons to the oxidized flavin cofactor to generate an amine radical cation intermediate. Subsequent opening of the strained cyclopropylamine ring is thought to lead to a primary carbon centered radical that inactivates the enzyme by covalent modification of the flavin or an essential active site functionality. We now have examined the MAO-B inactivator and substrate properties of 4-benzyl-1-cyclopropyl-1,2,3,6-tetrahydropyridine (11). This compound also is a time and concentration dependent inhibitor of MAO-B. Unexpectedly, however, compound 11 proved to be an excellent MAO-B substrate. These results are discussed in terms of possible catalytic pathways for the MAO-B catalyzed oxidation of 1,4-disubstituted-1,2,3,6- tetrahydropyridines.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗
Proximal jejunal obstruction due to eosinophilic gastroenteritis.
Eosinophilic enteritis or gastroenteritis is a rare disease characterised by tissue eosinophilia which can affect different layers of bowel wall. It can affect any area of gastrointestinal tract from the esophagus to the rectum, although stomach and small intestine are sites most frequently reported. It is important to recognize this disease early and institute the necessary treatment. An eight year old girl presented with acute intestinal obstruction. Exploration revealed a structure of proximal jejunum. Histopathology demonstrated eosinophilic jejunitis. The case is reported owing to this rarity and relevant literature is reviewed.
Acute Disease↗