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Biomedical subjects

A Kamińska

Publications and source records attributed to A Kamińska.

15 recordsLinked to original sources
PubMed1991

Type III collagen deficient EDS IV producing muscular hypotonia with abnormal muscle fibroblasts.

Muscle biopsy and fibroblast culture of a floppy child with Ehlers-Danlos syndrome type IV were studied. Biochemical analysis of the tissue showed drastically reduced amount of collagen type III. Electron microscopic examination of muscle as well as of cultured fibroblasts showed grossly dilated and dominated the cytoplasm endoplasmic reticulum. Dilatation may result from storage of an abnormal collagen type III molecule. Our observations indicate that type III collagen deficiency may be present clinically as a congenital muscle hypotonia. Specific ultrastructural abnormalities of fibroblasts found in muscle biopsy can enable the proper diagnosis.

Child↗
PubMed1991

Muscle cell death. Ultrastructural differences between muscle cell necrosis and apoptosis.

The morphology and incidence of muscle cell necrosis and apoptosis are presented. Necrosis which occurs as a massive tissue damage is structurally characterized by swelling of the muscle cell and disruption of cellular components. Apoptosis, on the other hand, is a process of active cellular self-destruction. It shows characteristic sequence of muscle cell shrinkage, which is ending in transformation of each muscle cell into compact apoptotic bodies that in turn are phagocytized by adjacent cells or macrophages.

Autophagy↗
PubMed1976

Myofibrillar protein pattern in experimental myotonia in rats.

Experimental myotonia was induced in rats by long-term administration of 20,25-diazacholesterol. Electrophysiological, morphological and biochemical investigations were carried out on m. soleus, m. extensor digitorum longus and m. gastrocnemius. The effect of 20,25-diazacholesterol administration on myofibrillar proteins was studied and a significant rise in the concentration of a protein presumed to be alpha-actinin was demonstrated in m. gastrocnemius. A change of the same character, not statistically significant, was observed in the m. extensor digitorum longus.

Actinin↗
PubMedDate not supplied

Apoptosis: a basic pathological reaction of injured neonatal muscle.

A light and electron microscopic study of immature muscle cell degeneration induced by bupivacaine (BPVC) was performed. The pattern of muscle cell death is related to muscle maturity; in newborn rats, cell death has the morphology of apoptosis, whereas in the older animals muscle cell death resembles cell necrosis and the ultrastructural feature of these changes are essentially the same as those described in adult muscle. The ability to undergo apoptosis in response to a pathological stimulus is a common effector mechanism of immature muscle.

Animals↗