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Biomedical subjects

A Karátson

Publications and source records attributed to A Karátson.

At least 37 records · Page 2Linked to original sources
PubMed1982

Iron turnover in patients with chronic uraemia treated with hemodialysis.

Radio-iron kinetic tests were performed in 7 patients with end-stage renal disease treated by hemodialysis; the study could be completed in 6 patients. The incorporation of radio-iron into the erythrocytes was 21% on average in patients with acute anemia. The red cell life-span determined in 4 patients became significantly shorter in 3 patients. Iron turnover in the bone marrow was significantly lower than normal, the rate of ineffective erythropoiesis being higher. Serum ferritin levels were significantly higher, and tissue and extravascular iron turnover was found to be enhanced compared to normal. At the same time, serum iron level was normal. The data on iron turnover indicated deficient hemopoiesis in the bone marrow, due partly to the lack of erythropoietin and partly to the insufficiency of the BFU-E (burst forming units) and CFU-E (colony-forming units) reserves. Undoubtedly, this was a consequence of the uremia.

Bone Marrow↗
PubMed1981

Infection of the abdominal cavity and chronic peritoneal dialysis.

Peritoneal dialyses have been performed in 1072 instances by the manual infusion technique in 16 patients with chronic renal failure, during a period of 2 years. Among the intraabdominal bacterial cultures done before each dialysis, 79 were positive, and peritonitis developed in 7 cases. As related to the total number of dialyses, these figures represent 7.37 and 0.65 per cent, respectively. Local intraabdominal applications has been found to reduce the hazard of peritonitis. Increased frequency of dialyses and combined antibiotic therapy proved curative to peritonitis. The results of the bacterial cultures indicate that in case of intraabdominal infections caused by Pseudomonas aeruginosa, acetate-containing dialysing fluids should be given preference.

Acetates↗
PubMed1980

[Clinical chemistry parameters in continuous peritoneal dialysis].

The continuous peritoneal dialysis (CAPD) is with four or five change of 1 1/2-2 l dialysis solution a day a 24 hours/day and 7 days/week dialysis. In 6 patients with terminal renal insufficiency the behaviour of biochemical parameters which serve as acknowledged indicators for the efficiency of a dialysis technique, were pursued under this method more than 4 weeks. At the end of the treatment period the following average values came up: creatinine 9.0 mg/dl, urea-N 65 mg/dl, anorganic phosphate 4.8 mg/dl (without Al-hydroxide), potassium 4.3 mval/l, calcium 4.1 mval/l and a pH-value of 7.35. The results allow the conclusion that with the CAPD a sufficient elimination of retention products is possible and values in the suburaemic region may be achieved similar to the conditions in the intermittent dialytic technique. Conclusions concerning a broad application of the technique in the terminal renal insufficiency may, however, not be made alone from these observations, since the problems of relapsing peritonitis and of the chronic loss of protein known from literature did not yet play a role in our patients in the short observation period.

Adult↗
PubMed1980

Effect of haemo- and peritoneal dialysis on the cell-mediated immune response in chronic uraemia.

Lymphocytopenia, decreased spontaneous rosette formation, and a decreased T lymphocyte count have been found in patients with non-uraemic glomerulonephritis (71 cases) and in different stages of uraemia (68 cases). In chronic glomerulonephritis and in the early stage of uraemia, cell-mediated hypersensitivity (lymphocyte migration inhibition) to glomerular basement membrane (GBM) characteristic of glomerulonephritis could be demonstrated. Hypersensitivity disappeared in the terminal stage of uraemia indicating endogenous immunosuppression.

Adult↗
PubMed1980

Satellite peritoneal dialysis.

In 29 cases of chronic renal failure 1325 peritoneal dialyses were performed between January 1, 1976 and April 31, 1978. The technique of peritoneal dialysis, the general lines of supervision and follow-up, the results and shortcomings of the procedure are discussed. Peritoneal dialysis is regarded as an alternative to haemodialysis in chronic renal failure. On ground of the favourable observations, organization of satellite PD services on a large scale, parallel with the expansion of other services (haemodialysis, renal transplantation), is advocated.

Adolescent↗
PubMed1979

Observations with the "Bi-flo" cannula (continuous, single-needle haemodialysis).

Observations with the double-lumen "Bi-flo" cannula in chronic intermittent haemodialysis are reported. On the evidence of urea and creatinine measurements, recirculation of blood corresponds to 7.9 and 6.1 per cent, respectively. In comparison with double-needle or single-needle dialysis, use of the double-lumen cannula does not affect the efficiency of dialysis to any notable degree. The advantages and shortcomings of the "Bi-flo" cannula with regard to the technique of dialysis are summed up.

Catheterization↗
PubMed1978

Factors influencing the prognosis of acute renal failure. (Analysis of 228 cases).

Two hundred and twenty-eight patients were treated for acute renal failure between October, 1964, and December 31, 1976. Complex antiuraemic therapy has been applied in 96, and haemodialysis or peritoneal dialysis in 132 cases. The overall mortality rate was 40.7%. The part played by age, primary process and possible complications of acute renal failure in the mortality figures is examined. From the analysis of clinical features, infections and septicaemia emerge as primary factors responsible for the high mortality. In conclusion the therapeutic measures which may minimize the hazard of inflammatory complications are summed up.

Acute Kidney Injury↗
PubMed1976

Haemorrhagic pericarditis and cardiac tamponade during chronic haemodialysis.

Three cases of uraemic haemorrhagic pericarditis observed during haemodialysis treatment are described. The condition is explained with uraemic toxicosis, cyclic heparinaemia resulting from dialysis, deficient thrombocyte function, and decreased capillary resistance. The clinical appearance of haemorrhagic pericarditis was not typical in any of the cases. Two patients died, while in one patient partial pericardiectomy was performed with success.

Adult↗
PubMed1976

Single-needle haemodialysis.

The single-needle method, which greatly simplifies the technique of haemodialysis, was tested for its efficiency by in vitro and in vivo studies. It has proved equal in efficiency to the conventional double-needle techniques. The possibilities of unilateral puncture of the femoral vein in association with the single-needle technique are pointed out.

Blood Urea Nitrogen↗
PubMed1976

Hepatitis and its problems in a haemodialysis Unit.

Current knowledge on the hazard of hepatitis in haemodialysis units is reviewed. Its routes of access and spread, and the possibilities of prevention are discussed. The preventive measures employed at the Haemodialysis Unit of the Department of Urology, University Medical School, Pécs, are outlined and the results reflecting three and a half years' experience are presented.

Hepatitis↗
PubMed1975

Estimated frequency of acute and chronic renal insufficiencies in a Transdanubian region of Hungary.

The literature on the incidence of chronic and acute renal insufficiency is reviewed and the results of own investigations in an area with a population of 1,560,000 are presented. Data were collected in questionnaires. The yearly incidence of patients with chronic uraemia requiring active therapy was estimated at 33 per 1 million population. The number of acute cases was 45 per million. The necessity of increasing the dialysis capacity is stressed. The importance of peritoneal dialysis in the therapy of uraemia cases which do not meet the requirements of the acute and chronic dialysis programmes is emphasized.

Acute Kidney Injury↗
PubMed1975

Renal handling of human beta2-microglobulin in the rat: the importance of sham-operation.

The plasma disappearance rates of human beta2-microglobulin and (hydroxy-methyl-C14)-inulin was measured in unoperated, sham-operated, ureter-ligated and nephrectomised rats. Judging from the C14-activity curves in ureter-ligated and nephrectomised rats a substantial glomerular filtration continued after obstruction of the urine flow. Almost 90% of the injected protein had disappeared from plasma 120 min after injection into nephrectomised rats indicating a considerable extra-renal elimination and invalidating attempts to evaluate different renal mechanisms of elimination before and after ureter-ligation. Sham-operation induced an increase of the plasma disappearance of both beta2-microglobulin and inulin. The latter phenomenon may explain earlier findings of similarity between the disappearance curves of low molecular weight proteins in unoperated and ureter-ligated animals and stresses the importance of using sham-operated animals as controls.

Animals↗