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Biomedical subjects

A Karev

Publications and source records attributed to A Karev.

At least 19 recordsLinked to original sources
PubMed1987

The mechanical efficiency of the pulley system in normal digits compared with a reconstructed system using the "belt loop" technique.

A specially designed tensiometer was employed to compare the mechanical efficiency of normal and reconstructed pulley systems in the thumb and the fingers. The "belt loop" technique for reconstruction was used in five fresh cadavers. A total of 10 thumbs and 40 fingers were dissected, and after a measured pull on the proximal tendon the yielded power output at the tip was compared with the normal and reconstructed systems. A mean of 10% loss of power in the reconstructed system in the thumb and 40% of power in the fingers, with excellent range of motion and no bow stringing was recorded.

Aged↗
PubMed1987

Dupuytren's contracture studied with monoclonal antibodies to connective tissue differentiation antigens.

Seventeen patients with Dupuytren's contracture underwent partial fasciectomy, and frozen tissue sections from the involved palmar fascia were prepared for binding studies with hybridoma-derived murine monoclonal antibodies (MoAb) recognizing connective tissue differentiation antigens. The two MoAb used were both generated using human sarcomas as immunizing agents, 23H7 known to bind to an antigen shared by selected sarcomas and carcinomas but not normal adult tissues except a subset of granulocytes, and 12C9 shown to recognize a common fibroblastic marker. MoAb 23H7 was discovered to bind to a subset of fibroblasts within the lesions of six of 17 patients with Dupuytren's disease. Occasionally it immunostained a single cell population associated with tissue granulocytes dispersed in the surroundings of the lesions. MoAb 12C9 was found to be expressed in only 12 of 17 specimens prepared from involved lesions from Dupuytren's disease. It is suggested that fibroblasts from selected patients with Dupuytren's contracture express a novel antigen, defined by MoAb 23H7, previously shown to be associated with human sarcomas and other neoplasia. The other fibroblast marker which is defined by MoAb 12C9 and known to be a common connective tissue antigen, is only occasionally expressed in lesions involved with this disease. Though additional markers associated with Dupuytren's contracture remain to be defined, the MoAb, capable of defining connective tissue differentiation markers, reported in this study may serve as new immunological probes for immunodissecting this syndrome into subsets of diseases which may better define the variety of clinical patterns presented by patients.

Adult↗
PubMed1986

Trapezius transfer for paralysis of the deltoid.

A case of selective paralysis of shoulder muscles with its reconstructive procedure, is presented. The deltoid, infra- and supraspinatus paralysed, leaving one of the steering group of muscles around the shoulder--the subscapularis--intact, made the transfer of the trapezius to deltoid feasible, utilizing a modification of Saha's technique. An excellent result with full range of motion of the paralysed shoulder has been achieved.

Adult↗
PubMed1985

Anatomic observations of the carpal tunnel in cadavers with a report of unusual thickening of the perineurium of the median nerve.

The carpal tunnel of 50 cadavers (100 hands) was dissected. Macroscopic finding included 14 median nerves with pressure signs (in 4 cadavers, unilaterally and 5 bilaterally). In three cadavers, marked synovitis was seen around the tendons and the nerve; in one, lipoma was evident; and in the rest, thickening of the volar carpal ligament was seen. Microscopic examination of the compressed nerves showed concentric thickening of the perineurium, thrombosis of veins, and intrafascicular fibrosis. In one nerve, the thickening of the perineurium was not concentric, but only at that part of the fascicle adjacent to the volar carpal ligament in an "onion peel" form.

Adult↗