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Biomedical subjects

A Karna

Publications and source records attributed to A Karna.

3 recordsLinked to original sources

Herniation of the transverse colon: an unusual complication of pedicled omentoplasty.

Pedicled omentoplasty is frequently used in chest reconstruction and treatment of sternal infection. The procedure is effective, but it is associated with several postoperative complications. The authors describe a 49-year-old man in whom sternal infection after heart surgery was successfully treated by sternectomy and omentoplasty. Several months later, the transverse colon herniated into the transposed omentum. To the authors' knowledge, this complication has not been previously reported.

Colonic Diseases↗

Serum levels of cancer-associated antigen CA-195 in gastrointestinal cancers and its comparison with CA19-9.

The antibody against CA-195 binds to an epitope that consists of both Lewis A and sialylated Lewis A blood group antigen, whereas CA19-9 has shown specificity for sialylated Lewis A blood group antigen. CA19-9 and CA-195 levels were measured in the sera of 52 normal subjects; 65 benign disease patients; and 74 non-gastrointestinal, 149 colorectal, and 119 upper gastrointestinal cancer patients to correlate their levels with disease status of the patients. Low incidence and levels were found among normal subjects for both markers; however, in the benign disease group a slightly higher incidence of elevation was seen for CA19-9. Among colorectal cancer patients CA-195 appeared to show higher sensitivity for primary as well as advanced disease. Levels of both markers showed similar incidences of elevation among upper gastrointestinal cancer patients. Based on these results the contribution of Lea specificity of CA-195 cannot be ruled out, and it may be used alone or in combination with other markers for monitoring of patients with colorectal, pancreatic, gastric, gall bladder, bile duct, and liver cancers.

Antigens, Tumor-Associated, Carbohydrate↗