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A Karpas

Publications and source records attributed to A Karpas.

122 records · Page 7Linked to original sources
PubMedDate not supplied

Lack of evidence for involvement of known human retroviruses in multiple sclerosis.

The recent report by Koprowski et al. that human T-cell lymphotropic retroviruses (HTLVs) may be involved in the development of multiple sclerosis (MS) has aroused much interest. The report was based largely on immunological evidence, using enzyme-linked immunosorbent assays (ELISAs) with viral antigens or disrupted virions. We have accordingly sought confirmation by screening sera and cerebrospinal fluid (CSF) samples from MS patients against cell lines infected respectively with adult T-cell leukaemia (ATL) virus (ATLV/HTLV-I) of Japanese cells (MT-1 and MT-2 lines), our own isolate from British black patients with ATL, the MoT cell line which produce HTLV-II, and our own T-cell line containing a local isolate of acquired immune deficiency syndrome (AIDS) virus (C-LAV/HTLV-III). We have failed to find antibodies against these retroviruses in the sera or CSF. Furthermore, neither virus could be isolated from the peripheral white blood cells of two MS patients.

Antibodies, Viral↗
PubMedDate not supplied

Human T cell leukemia virus-1 antibodies not detected in AIDS.

A collaborative study of sera from men in New York City with AIDS and at risk for AIDS, by investigators in Omaha, Cambridge and Kyoto, has failed to identify antibodies to human T cell leukemia virus I (HTLV-I).

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Viruses and leukemia.

Explore the source record for details and available documents.

Cell Transformation, Neoplastic↗