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Biomedical subjects

A Kaszuba

Publications and source records attributed to A Kaszuba.

At least 19 recordsLinked to original sources
PubMed2001

[Effectiveness of a micronized purified flavonoid fraction (MPFF) in the healing process of lower limb ulcers. An open multicentre study, controlled and randomized].

OBJECTIVE: To determine the increase in healing rate of venous ulcer in patients receiving a micronised purified flavonoid fraction (MPFF) as supplementation to standard local care. METHODS DESIGN: A randomised, open, controlled, multicentre study. SETTING: Departments of Dermatology and University Outpatients Clinics. PATIENTS: One hundred and forty patients with chronic venous insufficiency and venous ulcers. INTERVENTION: PATIENTS received standard compressive therapy plus external treatment alone or 2 tablets of MPFF daily in addition to the above treatment for 24 weeks. MAIN OUTCOME MEASURE: Healing of ulcers and their reduction in size after 24 weeks of treatment. RESULTS: The percentage of patients whose ulcers healed completely was found to be markedly higher in those receiving MPFF in addition to standard external and compressive treatment than in those treated with conventional therapy alone (46.5% vs 27.5%; p<0.05. OR=2.3, 95% CI 1.1-4.6). Ulcers with diameters <3 cm were cured in 71% of patients in the MPFF group and in 50% of patients in the control group, whereas ulcers between 3 and 6 cm in diameter were cured in 60% and 32% of patients (p<0.05), respectively. The mean reduction in ulcer size was also found to be greater in patients treated with MPFF (80%) than in the control group (65%) (p<0.05). The cost-effectiveness ratio (cost per healed ulcer) in the MPFF group was 1026.2 compared with 1871.8 in the control group. CONCLUSIONS: These results indicate that MPFF significantly improves the cure rate in patients with chronic venous insufficiency.

Aged↗
PubMed1997

[White blood cell picture of the peripheral blood of psoriatic patients treated with PUVA and cignoline].

White blood cell picture of the peripheral blood was determined in 37 patients with psoriasis vulgaris treated with PUVA and cignoline. The studies were performed during active period of the disease, during its treatment and in the initial period of the remission. The results were compared with those obtained in 20 healthy age-matched persons and they were correlated with the skin surface area involved, duration of the diseases and duration of its latest relapse. In the active period of the disease per cent of peripheral blood neutrophils and basophils is significantly increased, while per cent of lymphocytes is lowered. Increased per cent of neutrophils positively correlates with the skin surface area involvement.

Administration, Topical↗
PubMed1988

[Lymphocyte transformation test following stimulation with a protein factor from neutrophilic granulocytes (PMNL) in psoriasis patients].

The lymphocyte transformation test (LTT) was given to 20 healthy subjects and 43 patients with generalized psoriasis vulgaris: it was given right after stimulation with PHA (spontaneous) and after stimulation with allogenic and autogenic protein factor (NPF). NPF was isolated from secondary lysosome granules of peripheral blood neutrophils. The results were analyzed using computer statistic tests. No distinct differences were noticed between the spontaneous transformation test in psoriatic patients compared to the controls. After stimulation with PHA, the percentage of blast cells was significantly lower in patients with psoriasis. When allogenic and autogenic NPF was used for stimulation, the LTT values were significantly higher in the psoriasis group than in the control subjects. This fact points out the increase in sensitivity of lymphocytes to NPF in active psoriasis and the possibility of abnormal neutrophil-lymphocyte interactions in vivo. This phenomenon may be intensified when under the influence of bacterial or viral agents, or medicaments; the degranulation of secondary lysosome granules of neutrophils occurs, causing the release of NPF. These investigations support our opinion that psoriasis is a systemic disease and that NPF plays a considerable role in the psoriatic reaction.

Adult↗
PubMed1987

[Leukocyte migration test following stimulation with protein factor of neutrophilic granulocytes (PMNL) in the peripheral blood of patients with psoriasis].

Blood investigations were performed in 43 patients suffering from generalized psoriasis vulgaris and 40 healthy test persons. The results were statistically evaluated with the help of the computer technique. In the patients with active psoriasis, we found stimulation of the leucocyte migration caused by the autogenic protein factor from the peripheral blood PMNL. In addition, we observed that a mechanism like this may occur in vivo under the influence of biological degranulation factors (bacterial antigens from intraorganic infection foci). The mechanism described ist likely to act in an autoimmunostimulating way on immunologic reactions and is one of the elements which stimulate the PMNL activity in psoriatics. These results support our opinion that psoriasis is a systemic disease and indicate the role of the PMNL protein factor regarding the development of the psoriatic reaction.

Adolescent↗
PubMed1977

Hospital emergency department surveillance system: a data base for patient care, management, research and teaching.

The Johns Hopkins Health Services Research and Development Center and Emergency Department have developed a processing and feedback mechanism to provide a data base for management planning, allocating available resources, research strategies to evaluate the quality of care and teaching programs to train physicians in emergency medicine. A 10% sample of all emergency department visits is randomly selected each day, and data collected on patient age, sex, race, marital status, mode of arrival, method of payment, census tract of residence, complaint, diagnosis, disposition, date of visit, and times of entry and departure. In addition, process data on nursing care are collected. A sub-sample is selected for telephone or household follow-up aimed at gathering outcome data as part of the surveillance study. Turnaround time from the subject's emergency department visit to provider's feedback is one month. Thus, an ongoing, current description of usage is available. Retrieval of data for longer time periods provides valuable information on daily, monthly and seasonal usage patterns.

Abstracting and Indexing↗
PubMedDate not supplied

Fungal flora in human skin and skin appendages infections in the region of Lódź, Poland.

In the years 1987-95, 3550 patients with mycotic skin infections were divided into two groups: a group of 2282 (64.3%) subjects with dermatophytosis and a group of 1268 (35.7%) subjects with other fungal infections. Among dermatophytes the most common infectious agent was Trichophyton mentagrophytes (33%), followed by T. rubrum (30%) and Microsporum canis (11%). A total of 17% of all infections were caused by Candida sp.

Arthrodermataceae↗
PubMedDate not supplied

[Retinoids in the treatment of skin diseases in the light of the data of the Dermatology Clinic, Medical Academy, in Lódź].

Tigason was applied in 51 patients with psoriasis and 19 with other skin diseases. In 18 patients was applied alone, in 42 combined with PUVA and in 10 with SUP. Roaccutan was applied in 18 patients with acne conglobata et phlegmonous resistant to other methods of treatment. Tigason was found to be a useful drug in psoriasis and some other skin diseases. The combination with PUVA or SUP allowed to reduce the doses of drugs and the dose of radiation. Roaccutan was found to be a useful drug in severe forms of acne vulgaris. The side effects of the treatment with retinoids were transient and they did not create danger to the patients.

Acne Vulgaris↗
PubMedDate not supplied

[Production of superoxide free radicals by peripheral blood leukocytes in patients with psoriasis treated by the Re-PUVA-C method].

The investigations were carried out in 20 patients with severe forms of psoriasis, and in 18 healthy subjects. The generation of free superoxide radicals by polymorphonuclear leukocytes of peripheral blood was evaluated by Bellavite et al. (1983) method by use superoxide dismutase of Sigma firm. The obtained results may confirm alterations in PMNL functions in patients with psoriasis observed by many authors. It may confirm the probability of damage of membrane structures and alterations in their bactericidal functions.

Adult↗
PubMedDate not supplied

[Evaluation of metabolic efficiency of the liver in patients with psoriasis by the antipyrine test].

In 47 patients with generalized psoriasis vulgaris and 23 healthy subjects the effectiveness of the hepatic metabolism reflected by drug biotransformation was assessed with the antipyrine elimination test. In the group of psoriatic patients there were 25 men and 22 women and in the control group--age-matched 12 men and 11 women. The half-time of antipyrine was longer and the clearance index was lower in the patients than those in the control group. The differences were statistically significant. After 2 weeks of PUVA or SUP-therapy the differences were more significant. The findings indicate an impairment of the liver metabolic effectiveness reflected by drug biotransformation in psoriatic patients.

Adult↗
PubMedDate not supplied

[Selective phototherapy (SUP) in the treatment of psoriasis].

113 psoriatic patients were treated with SUP combined with 0.1-0.3 per cent cignoline. The lamps produced by Heraeus were used, in 48 patients--Psorilux 3060 and in 65--Psorilux 5050. The first symptoms of improvement were visible after 7-10 days. The mean duration of the treatment was 4 weeks. In 46 per cent of the patients psoriatic eruptions disappeared completely and in the further 44 per cent ones a considerable improvement was observed. The better results were obtained in patients irradiated with lamp of greater power and in those, who received a greater number of irradiations. Severe side effects were observed only in 2 cases. Selective ultraviolet phototherapy was found to be a useful method in the treatment of psoriasis.

Adolescent↗
PubMedDate not supplied

[Lysozyme activity in the blood serum and lysosomes and lysosomal supernatant of neutrophils in patients with psoriasis treated by the PUVA method].

The determinations of the activity of lysozyme in the serum, lysosomes and lysosomal supernatant of neutrophil granulocytes were done in 33 patients with generalized psoriasis and in 19 healthy controls. A decrease of lysozyme activity was demonstrated in the serum, lysosomes and lysosomal supernatant in the patients. During treatment by the PUVA method this activity rose gradually above the values in the control group. Systematic determination of lysozyme activity may help in monitoring of treatment progress.

Adult↗