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A Katsanos

Publications and source records attributed to A Katsanos.

10 recordsLinked to original sources
PubMed2005

Comparison between fixed-angle and customised corneal-polarisation compensation methods in scanning laser polarimetric measurement of the retinal nerve fibre layer in glaucoma.

PURPOSE: To investigate the differences between the results of scanning laser polarimetric (SLP) measurements of the retinal nerve fibre layer thickness (RNFLT) made using two different corneal-polarisation techniques; customised (SLP-C), and fixed-angle (SLP-F) compensations. METHODS: Both SLP-C and SLP-F were performed on 37 consecutive phakic patients with chronic open-angle glaucoma, and on 14 healthy control subjects. One randomly selected eye per subject was evaluated. RESULTS: Both SLP-C and SLP-F parameters were able to discriminate between the glaucoma group and the control group, except in the case of the ellipse modulation, which differed significantly between the two groups with SLP-C (P=0.017), but not with SLP-F (P=0.056). When SLP-C and SLP-F values were compared, inferior maximum thickness and ellipse standard deviation were significantly lower with SLP-C in both groups (P<0.05 for each parameter). Superior maximum thickness was significantly lower in glaucoma with SLP-C than with SLP-F (P=0.006) and tended to be lower with SLP-C than with SLP-F in the control group (P=0.053). In the glaucoma group, it was only with SLP-C that a significant (positive) correlation between the superior maximum thickness and the inferior hemifield mean sensitivity (MS) (r=0.653, P<0.001), and between the inferior maximum thickness and the superior hemifield MS (r=0.420, P=0.023) was found. The other global and sectoral SLP parameters showed significant correlation with the corresponding visual field parameters with both techniques. CONCLUSION: Our findings suggest that SLP measurements with customised compensation provide more realistic results for RNFLT than those made with the conventional fixed-angle compensation.

Adult↗
PubMed2005

Influence of subfoveal choroidal neovascularisation on macular imaging with scanning laser polarimetry of the retinal nerve fibre layer.

PURPOSE: To investigate the influence of subfoveal choroidal neovascularisation (CNV) on macular imaging performed using scanning laser polarimetry (SLP) of the retinal nerve fibre layer. METHODS: SLP was performed on 22 consecutive patients with angiographically verified CNV, and on 23 healthy control subjects. One eye per subject was evaluated using the GDx Nerve Fibre Analyser. Regularity of the corneal retardation on the macular SLP images was assessed according to three criteria: (1) magnitude of the 'macular ratio', defined as the ratio of mean retardation values along two axes (the axis with the maximum retardation and the perpendicular one, corresponding in healthy eyes to minimum retardation); (2) the values of GDx parameters which are independent of quadrant position (ellipse modulation and ellipse average); and (3) the frequency of the regular 'bow-tie' polarisation pattern. RESULTS: 'Macular ratio' was significantly higher in the CNV group than in the control group (P<<0.001). Ellipse modulation did not differ between the groups, but ellipse average was higher in the CNV group (P=0.016). The variance for each of these two parameters was significantly higher for the CNV group (P<<0.001 for both comparisons). A 'bow-tie' pattern polarisation was seen in 23 of the 23 control eyes, but only in 7 of the 22 CNV eyes (P<<0.001). CONCLUSION: The results show that CNV influences the macular image obtained with SLP. This suggests that measurements with SLP may be disturbed for eyes with CNV when the customised corneal compensation method, which makes use of the macular retardation image, is employed.

Adult↗
PubMed2004

Scanning laser polarimetry of retinal nerve fibre layer thickness after laser assisted in situ keratomileusis (LASIK): stability of the values after the third post-LASIK month.

BACKGROUND: Monitoring the retinal nerve fibre layer thickness (RNFLT) is essential in the diagnosis and treatment of glaucoma. In a previous study we found that a decrease of the polarimetric RNFLT observed in the early period after laser-assisted in situ keratomileusis (LASIK) disappears or tends to disappear by the third post-LASIK month. PURPOSE: To study the stability of the "recovered" polarimetric retardation values between the third and twelfth month after LASIK. METHODS: Scanning laser polarimetry (SLP) with the classic GDx Nerve Fiber Analyzer was performed on 13 consecutive healthy subjects with no eye disease who underwent LASIK for ametropia correction. Measurements were performed preoperatively, then at 3 and 12 months postoperatively. RESULTS: Inferior, temporal and nasal average thickness as well as ellipse average thickness and average thickness showed no difference among the three time points (ANOVA, p > 0.05). Superior average thickness was significantly smaller both at three months (Sheffe test, p =0.008) and 12 months (p =0.006) than before LASIK. However, no difference was seen between the values measured at three months and at 12 months after LASIK (p =0.997). A statistically significant interaction between treatment type (myopic or hyperopic correction) and the change of retardation was found for the superior average thickness (two-way ANOVA, p =0.016). In this quadrant the RNFLT values of the myopic eyes decreased between the baseline and the month 3 measurements but became stable after that; the retardation of the hyperopic eyes remained unchanged throughout. CONCLUSION: RNFLT measured with the classic GDx device after LASIK shows transient changes probably due to the LASIK-induced alteration of the polarization and the healing process. The polarimetric RNFLT values, however, become stable by the third post-LASIK month, and show no further change until the end of the first year after LASIK. Baseline SLP measurements for long-term glaucoma follow-up can be obtained from the third post-LASIK month onwards.

Adult↗
PubMed2003

Influence of LASIK on scanning laser polarimetric measurement of the retinal nerve fibre layer with fixed angle and customised corneal polarisation compensation.

BACKGROUND/AIM: Retinal nerve fibre layer thickness (RNFLT), as measured with scanning laser polarimetry using the fixed angle corneal polarisation compensator (SLP-F), has been found to be reduced after uncomplicated laser assisted in situ keratomileusis (LASIK) compared to the pre-LASIK measurement. Since this virtual RNFLT thinning is attributed to the corneal changes induced by the LASIK, the authors investigated whether customised corneal polarisation compensation (SLP-C), which compensates for the actual corneal polarisation during each measurement, can avoid the LASIK induced, virtual changes of the polarimetric RNFLT values. METHODS: Scanning laser polarimetry using both the SLP-F and SLP-C methods (GDx-Access, software version 5.0) was performed on 15 consecutive healthy subjects with no eye disease who underwent LASIK for ametropia correction. The SLP measurements were performed before the surgery, then on day 1 and day 6 after LASIK. Thickness data from images of one randomly selected eye per subject were analysed using the ANOVA and Scheffe multiple comparison tests. RESULTS: Superior maximum, inferior maximum, normalised superior area, and normalised inferior area (SLP parameters representing the RNFLT at the superior and inferior poles of the optic nerve head) remained unchanged with SLP-C (ANOVA, p>0.05) but decreased (superior maximum, normalised superior area, Scheffe test, p<0.05) or tended to decrease (inferior maximum) after LASIK, when measured using SLP-F. In contrast, certain other parameters-namely, superior ratio and inferior ratio (representing the ratios between the superior or the inferior sector and the temporal sector), maximal modulation, and ellipse modulation decreased with SLP-C (Scheffe test, p<0.05), but remained stable with SLP-F (ANOVA, p>0.05) after LASIK. Superior to nasal ratio, symmetry of the superior and inferior RNFLT as well as the parameter showing the probability of having glaucoma (called "the number") remained unchanged with both types of corneal compensation (ANOVA, p>0.05). With SLP-C the parameter ellipse average thickness increased after LASIK (Scheffe test, p = 0.021). No parameter value altered between day 1 and day 6 after LASIK, for either method. CONCLUSION: The results suggest that the LASIK induced decrease of the polarimetric RNFLT, which is consistently detected with polarimeters when using the fixed angle corneal polarisation compensator, is due to alterations of the corneal polarisation. The use of customised corneal polarisation compensation avoids this virtual decrease of the polarimetric RNFLTHowever, our results suggest an increase of the measured retardation in the temporal quadrant of the SLP-C image after LASIK. Since ratios of parameters using the temporal RNFLT in the denominator are important in the polarimetric glaucoma diagnosis algorithm, their decrease as a consequence of using SLP-C needs further investigation.

Adult↗
PubMedDate not supplied

Correlation between polarimetric retinal nerve fiber layer thickness and retinal sensitivity determined with frequency-doubling technology.

BACKGROUND AND OBJECTIVE: Correlation between polarimetric retinal nerve fiber layer thickness measured with variable corneal compensation and retinal sensitivity measured with frequency-doubling technology (FDT) and standard automated perimetry (SAP) was investigated. PATIENTS AND METHODS: Twenty-four consecutive patients with chronic open-angle glaucoma and 17 healthy control subjects (1 randomly selected eye for each subject) were evaluated. RESULTS: For all subjects, quadrant scanning laser polarimetry parameters correlated positively with both FDT and SAP mean sensitivity of the opposite hemifield (P< .001). Global scanning laser polarimetry parameters correlated positively with FDT-mean sensitivity, SAP-mean sensitivity, and FDT-mean deviation, and negatively with SAP-mean deviation (in SAP, mean deviation is positive in case of sensitivity loss) (P < or = .02). The nerve fiber indicator also correlated with FDT-pattern standard deviation and SAP-corrected loss variance (P < or = .01). Using un-logged sensitivity values, no further correlations were found. CONCLUSION: Our results show that a similar structure-function relationship exists between polarimetric retinal nerve fiber layer thickness determined with variable corneal compensation and retinal sensitivity measured with SAP and FDT.

Adult↗