Biomedical subjects
Publications and source records attributed to A Katsas.
Two cases of carcinoma developing on old frostbite scars of the heel are presented. A short review of the subject follows, stressing the rarity of these "secondary" tumors and their general context within the skin cancers and the tragic experience of Greece with frostbite in the campaign of 1940-1941.
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The distribution of HLA-A and B antigens was studied in 100 patients with cholelithiasis and in 202 healthy individuals all of Greek origin. An increased frequency of HLA-Aw19 was found in patients (33 per cent) compared with controls (22 per cent) (p less than 0.05, RR 1.7). The increase of Aw19 was even higher for patients with a family history of the disease (44 per cent, vs 22 per cent, p less than 0.01, RR 2.7) and for patients with cholesterol gall stones (44 per cent vs 22 per cent, p less than 0.01, RR 2.5). No difference was seen in patients without a family history of disease or with mixed gall stones. These results suggest a genetic basis for the development of cholesterol gall stone disease.