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Biomedical subjects

A Kefalides

Publications and source records attributed to A Kefalides.

6 recordsLinked to original sources
PubMed1985

Prostacyclin-synthesis stimulating plasma factor and platelet sensitivity in preeclampsia.

Hemostatic regulation is partly maintained by antiaggregatory and vasodilative prostaglandins (PGI2, PGE1, PGD2) and by the proaggregatory and vasoconstrictive Thromboxane A2. PGI2-Synthesis is regulated by a plasma factor (PF). This plasma factor and the platelet sensitivity (PS) to PGI2 and PGE1 decrease during pregnancy towards term. In preeclampsia PF and PS is more decreased than in healthy pregnant women. Both parameters increase significantly after delivery. The decreased values of PF and PS in preeclampsia demonstrate a dysregulation of hemostasis in preeclampsia.

Epoprostenol↗
PubMed1982

Reduced umbilical artery prostacyclin formation in complicated pregnancies.

Prostacyclin synthesis is severely depressed in the umbilical arteries of neonates of mothers with gestational diabetes mellitus, juvenile-onset diabetes mellitus, or preeclamptic symptoms, and of mothers who smoke during pregnancy and diabetic mothers who smoke. The reduced production of prostacyclin might be responsible for an increased abortion rate and a higher rate of intrauterine fetal death because of a decrease in placental perfusion and umbilical blood flow.

Adult↗
PubMed1982

[Plasma factors regulating prostacyclin synthesis during pregnancy].

Prostacyclin is the most potent endogenous inhibitor of platelet aggregation known so far, produced by endothelial and smooth muscle cells. This substance is assumed to play a key role in maintaining a sufficient blood flow in maternal and fetal circulation. There is now some evidence that there is a non-cellular component in human blood, which is able to influence the prostacyclin formation to a certain degree, the so-called "prostacyclin synthesis stimulating plasma factor". A change in the plasma factor activity in patients with a disturbance of PGI2 metabolism has been observed. We examined the activity of this plasma factor during pregnancy and one year after delivery. During the first and second trimenon increased values were observed, whereas at the end of pregnancy the values were significantly decreased. The values for plasma factor activity one year after delivery were comparable to those of the control group. In patients with diabetes mellitus decreased activity of the plasma factor was observed, but its course was similar to that seen in normal pregnancy.

Biological Products↗
PubMed1982

[Prostacyclin synthesis-stimulating plasma factor in different age groups].

The vascular synthesis of prostacyclin (PGI2), the most powerful endogenous inhibitor of platelet aggregation and vasodilator, plays a central role in prevention of vascular damages by uncontrolled platelet aggregation. PGI2 seems to be an important defense mechanism of vascular system against, among others, the development of atherosclerosis. The PGI2-production of blood vessels is stimulated and thereby decisively influenced by a plasma factor (PF). This PF participates in the pathogenesis of several diseases. This activity of PF is for instance increased in renal insufficiency, which explains partly the haemorrhagic diathesis occurring in this illness. On the other hand there seems to be a hereditary lack of PF in patients suffering from thrombotic-thrombocytopenic purpura or haemolytic-uraemic syndrome. The PF was estimated in 62 healthy subjects collected in 8 age groups by means of bioassays and RIA-determination of 6-oxo-PGF1 alpha, the stable PGI2-metabolite, in tissue cultures. No differences of PF in the different age groups could be demonstrated. These findings support the view, that the PF as an important regulator of vascular PGI2-synthesis is functioning absolutely normal in older age.

Adolescent↗