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A Kemény

Publications and source records attributed to A Kemény.

16 recordsLinked to original sources
PubMed1984

[Prolactin-producing hypophyseal adenomas].

It is a report about the diagnostic and the therapy of 10 women with a hyperprolactinemia caused by microadenomas of the hypophysis. The diagnose was made by reason of clinical symptomatology and hormonal and neuroradiological investigations. In six cases the tumor was removed by transsphenoidal route. One women does not give her consent to the microsurgical operation. In three patients the operation seemed not to be indicated absolutely. We gave them a longlasting therapy with bromocriptine. After operation galactorrhea decreased and we found ovulatory cycles in any case. It was concluded, that the results may be better, if the patients are dealt with bromocriptine for a long time, so abolishing the still existing complaints.

Adenoma↗
PubMed1983

Management of hormone-secreting pituitary microadenomas.

Experience with 22 patients with pituitary microadenoma is discussed. The diagnosis was based on examination of the contour of the normally sized sella turcica by multidirectional thin-layer tomography, and measurement of the pituitary hormone reserve capacity. Of the patients 13 had a microprolactinoma and 9 a microsomatotropinoma; 13 were subjected to trans-sphenoidal microadenomectomy and 14 received drug treatment. The problems of diagnostics and the choice of therapy are discussed.

Adenoma↗
PubMed1980

Purification of an endopeptide to homogenity and the verification of its selective inhibitory action on myeloid cell proliferation.

The purification of an endogenous regulatory peptide to homogeneity which selectively inhibits the proliferation of normal and leukaemic myeloid cells is described. Leucocytes isolated from calf spleen or horse blood were homogenized, extracted by acetone, chloroform and distilled water, ultrafiltrated by Amicon Diaflo XM 50 and PM 10 membranes. The lyophilized filtrate was chromatographed on Sephadex G-15 and G-10 columns. Fractions were tested for the selective inhibition of myeloid proliferation by 3H-TdR incorporation and capillary colony formation. The active fractions were submitted to paper electrophoresis at pH 6.5 and 1.9, and the peptides were re-tested. Finally a ninhydrin negative and chlor-tolidine positive oligopeptide was identified as granulocyte-specific inhibitor, effective at 0.2 to 3.0 pmol/ml MED value in vitro. The peptide is negatively charged at pH 6.5, its electrophoretic mobility as compared to aspartic acid is -0.60. The peptide has no charge at pH 1.9, the mobility related to epsilon-DNP lysine is 0.26. Details of the structure analysis of the inhibitory endopeptide is described in our next paper.

Animals↗