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A Keyeux

Publications and source records attributed to A Keyeux.

27 records · Page 2Linked to original sources
PubMed1975

The modification of sodium excretion after abdominal irradiation. A dose-effect relationship study in the rat.

Whole-body counting of radiosodium disappearance in the rat enabled us to evaluate the disturbance induced in sodium excretion after gamma abdominal irradiation at different doses (500, 750, 1000, 1250 and 1500 R). The observed modification is consistent with a sodium excretion loss depending on the dose. Two indices, the relative excretion rate (theta) and the recovery time (deltat), completely define the radio-induced modification and make feasible the quantitative assessment of its dependence on the dose. The development of the dose-response relationship established for each of these indices leads us to conclude that the reduction in the sodium-excretion rate, which can be related to a defect in sodium intake, is a linear function of the dose, while the time needed to recover the pre-irradiation sodium excretion rate increases exponentially with the dose.

Abdomen↗
PubMedDate not supplied

MR-monitored remitting-relapsing pattern of cortical involvement in Rasmussen syndrome: comparative evaluation of serial MR and PET/SPECT features.

We report the serial MR and PET/SPECT findings in a 2 1/2-year-old boy presenting with Rasmussen syndrome and highlight the close qualitative correlations between the results of the imaging modality and the functional isotopic techniques. The latter demonstrated a wider field of extension of the disease process. Routine MRI demonstrated its ability to detect brain changes matching the more sensitive PET and SPECT data and correlated well with the clinical evolution.

Brain Diseases↗
PubMedDate not supplied

Potentiation of radiotherapy by nontoxic pretreatment with combined vitamins C and K3 in mice bearing solid transplantable tumor.

BACKGROUND: The effect of intraperitoneal and oral pretreatment with combined vitamins C and K3 on the single dose radiotherapy of a transplantable solid mouse tumor have been investigated. MATERIALS AND METHODS: Groups of mice bearing intramuscularly transplanted liver tumors, were orally and parenterally pretreated with combined vitamins C and K3 and locally irradiated with single doses of 20, 30, or 40 Gy of X-rays. After this treatment tumor dimensions were measured twice weekly and the approximate tumor volume in groups of pretreated vitamins and irradiated mice was compared to the groups of mice only irradiated and to the absolute control groups without any therapy. RESULTS: This nontoxic pretreatment produced statistically significant potentiation of radiotherapy induced by 20 to 40 Gy of X-rays doses in groups of 11 to 20 mice. Combined vitamins C with K3 most probably constitute a redox-cycling system producing hydrogen peroxide and other active oxygen species to which cancer cells are selectively sensitive due to their frequent deficiency in enzymatic defense system against free oxyradicals agression. CONCLUSIONS: A possible introduction of such nontoxic and selective potentiation procedure into classical protocols of human cancer therapy appears to be generally accessible and without any additional risk for patients.

Animals↗