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Biomedical subjects

A Kh Kasymov

Publications and source records attributed to A Kh Kasymov.

At least 19 recordsLinked to original sources
PubMed2001

[Application of carbon sorbents in the treatment of experimental peritonitis].

Comparative estimation of efficacy of sorpents SKN-1K, KAU, AU-L in experimental peritonitis was performed. Most favourable effect was observed after performance of hemosorption using AU-L. Sorpent KAU caused very pronounced detoxicational effect, but while its application additional correction of the glucose level is necessary, and that's why it is contraindicated in hypoglycemia. SKN absorbs toxic products least actively, but corrects the carbohydrate metabolism indexes better than KAU.

Animals↗
PubMed1992

[The modelling of diffuse peritonitis].

Peritonitis is still an urgent problem and its solution is determined to a great measure by purposeful studies in the field of pathogenesis and treatment. The creation of adequate models of peritonitis acquires particular significance. Eighty-four animals (dogs) were used to create the model. It is shown in the work that a standard model of generalized peritonitis can be produced by two injections of a polymicrobial suspension consisting of the most commonly encountered peritoneal microbes E. coli and B. fragilis. The suspension is injected into different levels of the abdominal cavity. With this method of administration of the polymicrobial suspension the model was reproduced in 90% of cases. Thus, the developed model resembles human peritonitis in the clinical picture and the laboratory and morphological values.

Animals↗
PubMed1992

[Side effects of hemosorption in the treatment of acute hepatic insufficiency].

The authors have established that in hemosorption with the use of the KAU type sorbent, the biologically active substances, which are the substrates of carbohydrate, lipid and protein metabolism were eliminated from the blood. After termination of a seánce of hemosorption, levels of all the substances studied were normalized. However, total protein content was not reestablished.

Acute Disease↗
PubMed1991

[Effect of hemosorption and ultraviolet irradiation of blood on the blood levels of oligopeptides and biogenic amines in peritonitis].

Hemosorption permits more rapid and significant decrease in blood plasma concentration of oligopeptides. But at the same time, the decrease in concentration of a number of biogenic amines is noted. Under the influence of ultraviolet irradiation of the autologous blood, the reduction in manifestations of intoxication occurs slower, but norepinephrine production increases, contributing to improvement in the state of systemic hemodynamics and microcirculation.

Animals↗
PubMed1990

[Possibilities of hemosorption using a fibrous sorbent in acute hepatic failure (experimental study)].

The purpose of the experiment was study of the effect of hemosorption with the polymer sorbent PP-PAA (polypropylene-polyacrylic acid) on some hemodynamic values and level of metabolites in the blood of animals with acute hepatic failure. It was found that in perfusing blood through this sorbent there is practically no loss of total protein, the level of the studied metabolites in the blood reduces considerably, and the hepatic blood flow improves.

Acrylic Resins↗
PubMed1990

[Effects of benzonal on intracardiac hemodynamics in experimental myocardial infarct].

Benzonal was tested for effects on the natural history of experimental myocardial infarction. Systemic and intracardiac hemodynamic parameters were studied in 35 Shinshilla rabbits. Benzonal was found to exert a positive action of myocardial diastolic relaxation and to be beneficial on the natural history of experimental myocardial infarction.

Animals↗
PubMed1985

[Effect of hemosorption on the ultrastructure of hepatocytes in toxic liver damage].

Extracorporeal perfusion of toxic blood via carbonic sorbents is an effective method for correcting severe disturbances of hemostasis. Ultrastructural alterations in hepatic cells were studied in experimental toxic liver injury before and after hemosorption. It was established that after hemosorption the processes of intracellular regeneration were significantly activated in the liver parenchyma. The number of crysts in the mitochondria increased as did the electronic density of the matrix. At the same time the number of lysosomes rose as well. However, in persistent unresolved cholestasis, destructive alterations in the hepatic tissue progressed despite the performance of hemosorption.

Animals↗
PubMed1979

[Effect of auxilliary orthograde perfusion on lesser circulation hemodynamics].

The causes of disorders of the venous return of blood to the heart in development of acute experimental cardiovascular insufficiency were studied. It was established that grave hemodynamic disturbances in pulmonary circulation are the consequence but not the cause of the sharp decrease of venous blood return to the heart with the development of acute cardiovascular insufficiency.

Acute Disease↗
PubMedDate not supplied

[Efficacy of baxtims in eliminating dysfunction of the liver monooxygenase system in exotoxinemia].

The hepatoprotector activity of baxtims was studied with respect to hepatobiliary system pathologies. The tetrachloromethane and bulldok induced liver damage is accompanied by a significant decrease in activity of the monooxygenase system, which leads to violation of the detoxicant function and protein synthesis function of liver, followed by the development of engenous intoxication. Baxtims produced a pronounced hepatoprotector effect in the case of liver damage induced by toxicants of various chemical nature. The drug favors an increase in the concentration of cytochromes in liver microsomes, a decrease in the level of medium-molecular-mass peptides, and normalization of the protein synthesis. This hepatoprotector action justifies the drug administration in cases of exotoxinemia.

Animals↗