Biomedical subjects

A Khelif

Publications and source records attributed to A Khelif.

At least 19 recordsLinked to original sources

PubMed2006

Complete band gaps in two-dimensional phononic crystal slabs.

The propagation of acoustic waves in a phononic crystal slab consisting of piezoelectric inclusions placed periodically in an isotropic host material is analyzed. Numerical examples are obtained for a square lattice of quartz cylinders embedded in an epoxy matrix. It is found that several complete band gaps with a variable bandwidth exist for elastic waves of any polarization and incidence. In addition to the filling fraction, it is found that a key parameter for the existence and the width of these complete band gaps is the ratio of the slab thickness, d, to the lattice period, a. Especially, we have explored how these absolute band gaps close up as the parameter d/a increases. Significantly, it is observed that the band gaps of a phononic crystal slab are distinct from those of bulk acoustic waves propagating in the plane of an infinite two-dimensional phononic crystal with the same composition. The band gaps of the slab are strongly affected by the presence of cutoff frequency modes that cannot be excited in infinite media.

Journal Article↗

PubMed2006

Evidence for complete surface wave band gap in a piezoelectric phononic crystal.

A complete surface acoustic wave band gap is found experimentally in a two-dimensional square-lattice piezoelectric phononic crystal etched in lithium niobate. Propagation in the phononic crystal is studied by direct generation and detection of surface waves using interdigital transducers. The complete band gap extends from 203 to 226 MHZ, in good agreement with theoretical predictions. Near the upper edge of the complete band gap, it is observed that radiation to the bulk of the substrate dominates. This observation is explained by introducing the concept of the sound line.

Journal Article↗

PubMed2006

Identification of the translocation t(15;17) in acute myeloid leukemia (AML) initially classified as FAB M1: case report and review of the literature.

We report a case of a patient aged about 53 years, who initially presented with hematological disorders (WBC: 44000/mm3, Hb: 11g/dl, Pit: 127000/mm3) without tumoral syndrome. The Wright-Giemsa stained bone marrow and peripheral blood smears showed a population of blast cells characterized by cells with high N/C and strongly basophilic cytoplasm without granules. The nuclei were predominantly round. Nuclear chromatin was fine and contained small nucleoli. Cytochemisty was positive for peroxidase activity. Immunophenotyping showed myeloid typical markers of granulocytic lineage (MP0+, CD13+, CD33+, CD117+, CD34-). The karyotype revealed the expression of t(15;17) chromosomal translocation. The diagnosis of acute myeloid leukaemia (AML) was then evoked initially. The cytological features corresponded closely to the M1 subtype as defined in the FAB classification. The patient was treated with induction therapy according to the 7/3 protocol. One month later, he was discharged from hospital on hematological and cytogenetic remission. He died at home because of a heart attack. From the biological findings the patient was retrospectively diagnosed as having promyelocytic leukemia (hyperbasophilic form).

Biomarkers, Tumor↗

PubMed2004

Guided elastic waves along a rod defect of a two-dimensional phononic crystal.

It was shown that elastic waves propagating out-of-plane in a two-dimensional phononic crystal can experience full-band-gaps for nonzero values of the wave-vector component parallel to the rods. By further inserting a rod defect, it is demonstrated that modes propagating along the rod defect can be localized within the band-gaps of the phononic crystal. Such waveguide modes are exhibited for a tungsten/epoxy composite containing an aluminum nitride rod as the rod defect. It is expected that guided modes of such a structure can be excited and detected electrically owing to the piezoelectric effect.

Journal Article↗

PubMed2004

Tunable filtering and demultiplexing in phononic crystals with hollow cylinders.

Acoustic band gap (ABG) materials constituted of steel hollow cylinders immersed in water can exhibit a tunable narrow pass band (NPB) located inside their gap. We theoretically investigate, using the finite difference time domain (FDTD) method, the properties of waveguides composed of a row of hollow cylinders in a two-dimensional (2D) phononic crystal made of filled steel cylinders. These waveguides exhibit NPB's at frequencies slightly higher than their infinite periodic ABG counterpart. The frequency of the waveguide's NPB can be selected by adjusting the inner radius of the hollow cylinders or by changing the nature of the fluid that fills them. We show that a waveguide constituted of a row of hollow cylinders with different inner radii can transport waves at two different frequencies. By selectively filling the cylinders with water or mercury we have created an active device that permits the transmission of waves at one, both, or neither of these frequencies. Finally, we examine the multiplexing and demultiplexing capabilities of Y shaped waveguides constituted of hollow cylinders.

Journal Article↗

PubMed2003

Out-of-plane propagation of elastic waves in two-dimensional phononic band-gap materials.

We have used a plane-wave-expansion model to study the out-of-plane propagation of elastic waves in a two-dimensional phononic band-gap material. The case of quartz rods embedded in an epoxy matrix has been computed. Band gaps for nonzero values of the wave-vector component parallel to the rods are shown to exist and are investigated. For wavelengths smaller than the period of the structure, modes are found that are localized in the epoxy intersites, and propagate perpendicularly to the plane of the structure.

Journal Article↗

PubMed2003

Hydatid cyst of the right atrium and rheumatic mitral disease: a fortuitous association.

Ecchinococcal infestation of the heart accounts for only 0.5-2% of ecchinococcosis cases. A case is reported of right atrial hydatid cyst associated with rheumatic mitral valve disease in a 43-year-old woman. Physical examination and chest X-radiography revealed mitral disease. Transthoracic and transesophageal echocardiography demonstrated a single, large cystic mass of 4 x 4 cm located in the right atrium, and heavily calcified mitral rheumatic disease with commissural fusion. Confirmatory computed tomography and magnetic resonance imaging excluded other extracardiac locations. Radioisotopic lung perfusion scanning and angiographic scanning excluded pulmonary embolism. The patient underwent mitral valve replacement and the hydatid cyst was excised. An intraoperative examination and subsequent pathology confirmed a diagnosis of hydatid cyst.

Adult↗

PubMed2002

Evidence of fano-like interference phenomena in locally resonant materials.

Sonic crystals consisting of three-dimensional arrays of units which exhibit localized resonances have been discovered recently. Here, it is shown that their two-dimensional counterparts behave in a similar manner. Particularly, it is observed that the transmittance spectra show very asymmetric peaks which are explained as a Fano-like interference phenomenon. A finite difference time domain method is employed to perform a comprehensive study of the resonance line shape as a function of the mass density of the structural units. Also, a simple analytical model is introduced to give an intuitive account of the origin of the interference phenomenon.

Journal Article↗

PubMed2002

Phononic crystal with low filling fraction and absolute acoustic band gap in the audible frequency range: a theoretical and experimental study.

The propagation of acoustic waves in a two-dimensional composite medium constituted of a square array of parallel copper cylinders in air is investigated both theoretically and experimentally. The band structure is calculated with the plane wave expansion (PWE) method by imposing the condition of elastic rigidity to the solid inclusions. The PWE results are then compared to the transmission coefficients computed with the finite difference time domain (FDTD) method for finite thickness composite samples. In the low frequency regime, the band structure calculations agree with the FDTD results indicating that the assumption of infinitely rigid inclusion retains the validity of the PWE results to this frequency domain. These calculations predict that this composite material possesses a large absolute forbidden band in the domain of the audible frequencies. The FDTD spectra reveal also that hollow and filled cylinders produce very similar sound transmission suggesting the possibility of realizing light, effective sonic insulators. Experimental measurements show that the transmission through an array of hollow Cu cylinders drops to noise level throughout frequency interval in good agreement with the calculated forbidden band.

Journal Article↗

PubMed2002

Theory of acoustic scattering by supported ridges at a solid-liquid interface.

We combine a general Green's function formalism and an approach due to Nyborg [W. L. Nyborg, in Acoustic Streaming, Physical Acoustics, edited by W. P. Mason (Academic, London, 1965), Vol. II B, Chap. 11] to calculate the first-order pressure and second-order pressure gradient fields in the vicinity of solid inhomogeneities at a solid/liquid interface. We treat the problem of scattering of an incident acoustic plane wave by a single ridge and two parallel ridges separated by a trench on a planar substrate. The calculated vibrational density of states shows the existence of resonances at low frequencies, especially in the case of a trench. Excitation of a trench resonant vibrational mode enhances the magnitude of the first-order pressure and of the second-order pressure gradient. The resonant frequencies of a trench decrease and the pressure enhancement increases with increasing aspect ratio of the ridges (height to width).

Journal Article↗

PubMed2001

Stopping of acoustic waves by sonic polymer-fluid composites.

A two-dimensional periodic array of air cylinders in water is known to have giant acoustic stop bands [M.S. Kushwaha and B. Djafari-Rouhani, J. Appl. Phys. 84 (1998) 4677]. It is shown in the present paper that hollow cylinders made of an elastically-soft polymer containing air inside and arranged on a square lattice in water can still give rise to large acoustic band gaps. Similar properties can also be obtained with a close-packed array of tubes containing water when arranged on a honeycomb lattice in air. The transmission coefficient of films made of such polymer-fluid composites has been calculated by finite difference time domain method. With film thickness not exceeding 75 mm, a deep sonic attenuation band was found with, in the best cases, a lower limit below 1 kHz and an upper limit above 10 kHz.

Journal Article↗

PubMed2000

Diffusion monte carlo methods with a fixed number of walkers

In this paper we discuss various aspects of diffusion Monte Carlo methods using a fixed number of walkers. First, a rigorous proof of the divergence of pure diffusion Monte Carlo (PDMC) methods (DMC without branching in which the weights are carried along trajectories) is given. Second, a bias-free Monte Carlo method combining DMC and PDMC approaches, and based on a minimal stochastic reconfiguration of the population, is discussed. Finally, some illustrative calculations for a system of coupled quantum rotators are presented.

Journal Article↗

PubMed2000

[Acquired amegakaryocytic thrombocytopenic purpura treated with intravenous immunoglobulins].

Acquired amegakaryocytic thrombocytopenic purpura is a rare disorder characterized by severe thrombocytopenia due to the absence of bone marrow megakaryocytes. The pathogenic mechanisms of this disorder have not well defined; consequently, several empirical therapies are used. We reported the case of a 38-year-old mean who was hospitalized for serious bleeding syndrome. The platelet count was 10 yen10(9)/L. The bone marrow aspirate and biopsy showed the absence of megakaryocytes but otherwise normal granulocyte and erythroid precursors. No definable etiology has been found. After the unsuccessful use of prednisone, intravenous immunoglobulin therapy was started and resulted in favorable reponse.

Adult↗

PubMed1997

[Hemorrhagic syndrome and isolated alpha 2-antiplasmin deficiency. Apropos of a case].

An isolated alpha 2 plasmin inhibitor deficiency is reported in a 33 years old male, presenting repeated intramuscular hematomas since 5 years, spontaneously or after minor traumas. None of other family members were suffering from abnormal bleeding. Screening hemostatic examinations were normal except for a moderately shorted euglobulin lysis time (2 hours). Evaluation of fibrinolysis parameters (plasminogen, plasminogen activator inhibitor type 1, tissue plasminogen activator, fibrin and fibrinogen degradation products, alpha 2 plasmin inhibitor) showed normal values except for alpha 2 plasmin inhibitor which is markedly decreased (activity: 14%, antigen: < 5%). Familial hemostasis investigations have not been performed. This isolated alpha 2 plasmin inhibitor deficiency has been confirmed by two repeated control prelevments. Bleedings episodes were treated with antifibrinolytics agents (tranexamic acid). This case report shows the importance of the diagnostic approach in the laboratory to detect such rare hemostatic abnormalities associated with bleeding tendency.

Adult↗

PubMed1996

[Infantile visceral leishmaniasis: difficult diagnosis in cases complicated by hemophagocytosis].

BACKGROUND: Hemophagocytosis has already been reported in cases of visceral leishmaniasis and thus may complicate search for diagnosis. CASE REPORT: A previously healthy 2 year-old boy was referred for fever and splenomegaly with pancytopenia. An initial diagnosis of kala-azar was refuted because of absence of biological inflammatory syndrome, negativity of bone-marrow aspiration and splenic ponction and of specific serology. After three months of clinical deterioration and apparition of active hemophagocytosis, both bone marrow aspiration and specific serology for visceral leishmaniasis became positive. The boy was given sodium stibogluconate for 20 days; he improved gradually with complete and definitive remission. CONCLUSION: Diagnosis of visceral leishmaniasis may be difficult, even in countries where this condition is relatively frequent; the association with hemophagocytosis is possible and does not constitute a poor factor of prognosis if specific therapy is proposed.

Antimony↗

PubMed1996

A nonsense mutation in the GPIIb heavy chain (Ser 870-->stop) impairs platelet GPIIb-IIIa expression.

Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding disorder, caused by a quantitative or qualitative defect of the GPIIb-IIIa integrin (alpha IIb beta 3), which functions as the platelet fibrinogen receptor. We report a case of type I GT due to a homozygous mutation resulting in Ser 870 to stop codon substitution. This residue is located near the proteolytic cleavage site of proGPIIb. The mutation results in a GPIIb truncated of 138 amino acids, including transmembrane and intracytoplasmic domains. Cotransfection of an expression vector containing the mutant GPIIb and wild-type GPIIIa showed that the mutant Ser 870-->stop GPIIb was able to associate to GPIIIa. However, this heterodimer failed to mature as shown by endoglycosidase-H digestion and was therefore not expressed at the COS-7 cell surface. This report is the first description of a homozygous nonsense mutation in the GPIIb gene and highlights the role of the GPIIb light chain.

Adolescent↗

PubMed1995

First study of immunoglobulin and T cell receptor gene rearrangements in chronic and acute lymphoblastic leukemias from Tunisia.

We report the first characterization at the immunological and molecular level of 12 cases of chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL) from Tunisia. Our results show biallelic IgH gene rearrangement in B-CLL (6/6). A high ratio of T-ALL (4/6) was observed in Tunisian ALL leukemias. One T-ALL expressed CD10 (common ALL) which has already been found in some other cases of T-ALL. We report the occurrence of T cell receptor (TCR) beta and/or gamma gene rearrangements in two precursor B-ALL patients who had normally rearranged Ig genes. In one precursor B-ALL case, multiple rearranged IgH and TCR gamma bands allowed the identification of three clones. Such an oligoclonal ALL is interesting since only rare biclonal TCR beta or gamma gene rearrangements have been described.

Blotting, Southern↗

PubMed1994

[Screening of hemoglobinopathies and molecular analysis of beta-thalassemia in Central Tunisia].

BACKGROUND: Previous investigations have permitted to locate 16 beta-thalassemic mutations in different samples of the Tunisian population. One of them (IVS I nt 2: T--G) had been found only in the central region of Tunisia. Our research was carried out in this part of the country to estimate the prevalence of this mutation and to establish a prenatal diagnosis using appropriate probes. POPULATION AND METHODS: One thousand one hundred and five blood samples taken from 1987 to 1990 from healthy blood donors and 346 samples taken from 1985 to 1992 from patients were analysed. Detection of hemoglobinopathies was carried out by means of specific hematological tests and different electrophoretic and chromatographic techniques. Mutations were detected by means of the usual techniques of molecular biology. RESULTS: Sickle cell anemia and beta-thalassemia were the most frequent in the samples studied. The molecular analysis carried out on eight patients native of the Essouassi-El-Djem region point out that all these patients carry the same point mutation (IVS I nt 2: T-G) detected for the first time in 1988 in a patient native of the same region. One of these patients, aged 43, who did not suffer from anemia and did not show the usual symptoms of beta O thalassemia, had one hemolytic attack at the age of 17. CONCLUSIONS: The high number of persons carrying Hb S and beta-thalassemia trait increase the risk of appearance of homozygous forms. The presence of the same mutation IVS I nt 2: (T-G) in all beta O-thalassemic patients from Essouassi-El Djem region may indicate that it may have its origin there. The heterogeneity of clinical phenotype of these patients shows the difficulty of establishing a unique strategy of prenatal diagnosis by DNA analysing which can be applied in all cases.

Anemia, Sickle Cell↗