Silicone foam containing BLM and implanted in the cavity resulting from the resection of a tumor seemed to act against any tumor cells remaining in the resection site in microscopic amounts by slowly releasing this carcinostatic agent. The silicone foam is molded in precise accordance with the shape of the wound surface as it foams and hardens, leaving no space between the material and the wound surface. The carcinostatic agent released can, therefore, act on the entire surface of the wound, and the implantation also has a hemostatic effect. High tissue concentrations of the agent can be maintained for a long time due to the slow-release properties of the silicone foam. Systemic side effects of the procedure seem to be negligible. Local recurrence of cancer was observed in 11 (33.4%) of our 32 patients. Three-year survival was seen in 1 (50%) of the 2 patients with T2 lesions, 11 (68.7%) of the 16 with T3 lesions and 4 (66.6%) of the 6 with T4 lesions.

Adenocarcinoma↗

PubMed1986

CAP therapy for advanced, recurrent and/or metastatic malignant tumors of the head and neck.

One-day CAP therapy utilizing CPM, THP-ADM and CDDP was performed on 33 patients with malignant tumors in the head and neck region which were able to be evaluated. As a result, CR was obtained in 6 patients and PR in 11 patients; thus the overall response rate was 51.5%. The present therapy is worthwhile as a neo-adjuvant chemotherapy and it was effective in patients with relatively severe systemic condition or those with lung metastasis. When the tissues were classified histologically, the present therapy was effective against anaplastic carcinoma and adenocarcinoma. Since agents significantly effective against adenocarcinoma have not been available so far, the present therapy is considered to be a useful method especially for the treatment of adenocarcinoma. Moreover, because irreversible side effects scarcely appeared and because the period for 1 course of treatment is short enough, the present therapy is considered to be a method with little burden on patients.

Adenocarcinoma↗

PubMed1986

Combination chemotherapy with CDDP and 5-FU in head and neck cancer.

Combination chemotherapy with CDDP and 5-FU was performed in 19 patients with evaluable head and neck cancer and 2 CR patients and 7 PR patients were obtained; thus the response rate was 47.4%. Histologically, the present therapy is considered to be especially effective against well differentiated squamous cell carcinoma (83.3%). The present therapy is considered to be useful as a neo-adjuvant chemotherapy (75.0%), but it is desirable to perform at least 2 courses of treatment. The side effects observed were nausea, vomiting, anemia, leukocytopenia and alopecia, etc., and most of them were reversible. However, there were 2 patients in which the continuation of chemotherapy was impossible due to renal disorders.

Adenocarcinoma↗

PubMed1986

Combination chemotherapy with CDDP, 5-FU and PEP in head and neck malignant tumors.

Multi-drug combination therapy with CDDP, 5-FU and PEP was performed in 23 patients with malignant tumors in the head and neck region, and 2 CR patients and 9 PR patients were obtained with a response rate of 47.8%. The present therapy (CFP therapy) is considered to be especially effective against patients at low performance status grades with poorly differentiated squamous cell carcinoma which is located in regions receiving an abundant blood supply like the oral cavity. It is advisable to perform more than 2 courses of treatment as an induction chemotherapy. With respect to the method of administration of PEP, further study will be made in the future.

Adult↗

PubMed1986

T-lymphocyte subsets in patients with squamous cell carcinoma of the head and neck.

T-lymphocyte subsets in the peripheral blood of patients previously untreated for squamous cell carcinoma of the head and neck were investigated using monoclonal antibodies under flow cytometry before starting treatment. T-lymphocyte subsets in the peripheral blood of patients with squamous cell carcinoma did not significantly differ from those in the peripheral blood of healthy subjects, patients with benign tumors of the head and neck, patients with chronic sinusitis and patients with benign otolaryngological diseases. The necessity to investigate the function of T-lymphocyte subsets was suggested. It was furthermore suggested that T-lymphocyte subsets in cancerous tissues should be investigated.

Adult↗

PubMed1985

[Dependence of radiosensitizing effect on the temperature of hyperthermia].

Explore the source record for details and available documents.

Animals↗

PubMed1985

Serum immunosuppressive acidic protein (IAP) in patients with malignant head and neck tumors.

Measurements were carried out on the serum immunosuppressive acidic protein (IAP) level of patients with malignant head and neck tumors. The serum IAP value in patients with malignancies was significantly higher than that in healthy subjects and those with benign tumors. Following treatment, in cases with favorable progress the high IAP values prior to treatment showed a decline, becoming normal. Whereas in cases showing poor progress, there was a delay in reverting to normal values and some were observed to retain the same high values.

B-Lymphocytes↗

PubMed1977

[Ultrastructural study of the chorda tympani nerve in man (author's transl)].

Chorda tympani nerve specimens of 10 patients were studied by the light and electron microscope. The nerve specimens were obtained while performing stapedectomy in 7 patients, a tympanoplasty in two patients with otitis media chronica, and from one patient whodied 8 months after hemiglossectomy, neck-dissection and radiotherapy because of squamous cell carcinoma. The chorda tympani nerve is built up by few 10 to 12 micron thick and numerous 3 to 4 micron thick myelinated fibers in the semithick sections. The 10 to 12 micron axons are largely reduced in patients with chronic middle ear infection and in older patients. In persons with otosclerosis degenerative alterations of the axons and inclusions in the cytoplasm of the Schwann cells can be demonstrated similar to those of the diabetic, alcohol induced and ischemic neuropathy. In patients with chronic middle ear disease the degenerative changes mainly occur in the myelin sheats and in axoplasma finally leading to axolysis. A total degeneration and fibrous transformation of the chorda tympani nerve can be observed after hemiglossectomy. By means of morphological criteria afferent and efferent axons can not be distinguished in this material.

Adult↗

PubMed1975

[Where lies the boundary between common sensation and taste perception in electrogustometry (author's transl)].

The shift of the electrogustatory threshold following section of the corda tympani has been investigated in 14 patients. Postoperatively the anterior half of the tongue showed complete ageusia. Two thirds of the patients were able to recognize stimulations of 50-127 muA as a burning, and not a sour metallic, sensation for at least 1-2 weeks. Probably the trigeminal nerve endings perceive this burning sensation during the period of taste bud degeneration. A similar situation exists in cases where the gustatory fibres are interrupted proximal to the gustatory ganglion, because the tasts buds do not degenerate. It is therefore important to ask the patient to describe the sensation experienced. Only a sour metallic taste during electrogustometry should be regarded as a true gustatory sensation.

Adult↗