PubMed Health⌕ Search

Biomedical subjects

A Killam

Publications and source records attributed to A Killam.

5 recordsLinked to original sources
PubMed1998

Unconjugated estriol as an indication for prenatal diagnosis of steroid sulfatase deficiency by in situ hybridization.

BACKGROUND: Undetectable or very low unconjugated estriol (E3) levels in routine maternal serum screening are associated with steroid sulfatase deficiency, miscarriages, and anencephaly. CASES: Fluorescence in situ hybridization techniques were used in the diagnosis of steroid sulfatase deficiency prenatally in three cases with low or undetectable unconjugated E3 levels. Results showed a male fetus with a deleted steroid sulfatase region, but intact Kallmann syndrome region in all three cases. One mother was studied by fluorescence in situ hybridization and showed a similar deletion for steroid sulfatase gene in one copy of X chromosome (carrier). CONCLUSION: Women with undetectable or very low levels of estriol on serum screening should be counseled regarding steroid sulfatase deficiency with evaluation by fluorescence in situ hybridization.

Adult↗
PubMed1988

Expectant management of abdominal pregnancy. A report of two cases.

In two recent consecutive cases of abdominal pregnancy the diagnosis was made at 18 weeks' gestation, and the patients refused immediate surgery and elected to maintain the pregnancy until fetal viability developed. Both patients were managed expectantly with continuous antepartum hospitalization. Fetal assessment was by serial ultrasound assessment of growth and amniotic fluid volume and by nonstress testing. Planned operative delivery was accomplished at 28 1/2 weeks and 33 weeks' gestation. In the second case the diagnosis was confirmed by magnetic resonance imaging. That fetus was also assessed with umbilical artery Doppler flow studies. Despite significant morbidity, both the mothers and infants are alive and well.

Adult↗