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Biomedical subjects

A Kipps

Publications and source records attributed to A Kipps.

At least 19 recordsLinked to original sources
PubMed1981

Increased susceptibility to herpes simplex virus infections in children with acute measles.

Children with measles treated either in hospital or as outpatients were examined for clinical or laboratory evidence of oropharyngeal herpes simplex virus (HSV) infection. HSV was isolated from 43% of the hospitalized children and 37% of the outpatient children and an additional 9% of the hospitalized group had lesions without the virus being isolated. The incidence of both HSV isolation and clinical lesions in infected children was significantly greater in children hospitalized for measles than in a control group of children hospitalized for tuberculosis. Data from the outpatient group strongly suggest that malnourished children with measles are particularly susceptible to HSV infection. The immunosuppressed state of the children with acute measles was demonstrated by impaired lymphocyte transformation responses to phytohemagglutinin and the inability of their serum to support normal transformation responses by lymphocytes from normal individuals. However the extent of this immunosuppression was unrelated to the susceptibility of the children to HSV infection.

Child, Preschool↗
PubMed1980

Subacute sclerosing panencephalitis (SSPE) in southern Africa. Recent additions to the SSPE Registry.

Subacute sclerosing panencephalitis can no longer be regarded as a rare disease in all parts of southern Africa. Information derived from a third postal survey added to that from our own experience in Cape Town has brought to light 116 cases; 61 of the patients came from the Cape Province, 40 from the Transvaal and the remaining 15 from the other regions. This unequal distribution and the high prevalence in the Coloured community are important factors in any attempt to understand the epidemiology and the pathogenesis of this serious complication of measles.

Adolescent↗
PubMed1980

Atypical presentation of subacute sclerosing panencephalitis in 3 patients.

Experience with some of our patients suggests that the diagnosis of subacute sclerosing panencephalitis (SSPE) may be made early and confirmed by the demonstration of high levels of measles complement-fixing antibodies in the cerebrospinal fluid (CSF) and serum, in the absence of classic clinical, electroencephalographic or brain biopsy support for the diagnosis. It is not known when the measles-specific antibodies first appear in the CSF, but these 3 atypical cases suggest that they were present in high titre early in the disease.

Adolescent↗
PubMed1979

Serum complement concentrations, nutritional status and the outcome of measles and measles pneumonia.

A prospective study of children with measles has shown a significant association between malnutrition and a poor prognosis. Levels of a number of complement components bore no relationship to the severity of the disease or to its prognosis. Some of the children with acute measles had depressed serum concentrations of factor D, Clq or C3, but complement deficiency does not appear to be implicated in the heightened susceptibility to secondary bacterial and viral infection so commonly found after acute measles.

Body Weight↗
PubMed1977

Register of cases of subacute sclerosing panencephalitis (SSPE) in Southern Africa.

An analysis of cases of subacute sclerosing panencephalitis (SSPE) in Southern Africa to the end of 1976 is presented. In the 2 years since the last report in 1975, 15 new cases have been added to the register. Seven patients from the Cape Province were investigated in Groote Schuur and Red Cross War Memorial Children's Hospitals in Cape Town and a recent postal survey revealed 6 cases in the Transvaal and 1 each from South West Africa and Rhodesia. This analysis indicates that the high incidence and temporal clustering of cases in the Cape Province is continuing, and that the relatively constant annual number of cases in the Transvaal and the apparent absence of the disease in Natal and the Orange Free State are being maintained.

Adolescent↗
PubMed1977

Rubella--a reappraisal.

Rubella infection is reviewed and new information about congenital infection, possible sources of infection in pregnant women and the optimum ages and population groups for rubella vaccination is considered. Investigations required to confirm a suspected and possibly 'silent' infection during pregnancy are outlined.

Adolescent↗
PubMed1977

The epidemiology of rubella in Cape Town.

This preliminary study indicates that a high proportion of adult females in Cape Town are immune to rubella, and that, unlike the situation in the UK, natural rubella infections are common before 4 years of age. At least 10 children with the congenital rubella syndrome have been seen in the Cape Town group of teaching hospitals in a 5 1/2-year period since October 1971. Continuous serological surveillance is essential in order to implement the most effective programme of immunization in any particular area and also to be able to determine whether the vaccine is successfully preventing the birth of children with congenital rubella infection.

Adolescent↗
PubMed1976

Virus peneumonia following measles: a virological and histological study of autopsy material.

Adenovirus, measles virus and herpesvirus were found to be responsible for the serious non-bacterial bronchiolar and interstitial necrosis in post-measles pneumonia in underprivlieged non-White children less than 4 years of age in Cape Town. Secondary bacterial bronchopneumonia, possibly antibiotically suppressed, proved to be less important in accounting for the extensive lung damage in 18 fatal cases that were examined virologically and histologically.

Adenoviridae↗
PubMed1975

Subacute sclerosing panencephalitis in Southern Africa.

A first attempt to gather the available information on subacute sclerosing panencephalitis (SSPE) in Southern Africa has produced records of 79 cases which have occurred since 1955. An important feature of the epidemiology is the clustering of 48 cases in the 5-year period 1970-1974. Thirty of these patients were resident in the Cape Province, and most of them were from the Coloured community. An SSPE registry will be maintained at the MRC Virus Research Unit of the University of Cape Town and an appeal is made to all practitioners to contribute any relevant data on patients with this disease.

Adolescent↗
PubMed1975

A minimum age for measles vaccine administration to coloured children.

The antibody response to further-attenuated live virus measles vaccine was assessed in 67 Coloured children between the ages of 6 and 12 months. Children less than 9 months of age were found to have suboptimal seroconversion rates and it is recommended that the routine administration of measles vaccine should be restricted to children over the age of 8 months. High-risk groups and problems of vaccine administration and storage are discussed.

Black or African American↗