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Biomedical subjects

A Koĭchev

Publications and source records attributed to A Koĭchev.

15 recordsLinked to original sources
PubMed1988

[A comparison of the diagnostic reliability of the results of isotopic and routine clearance studies in essential and symptomatic hypertension].

40 patients with arterial hypertension II stage, 51 patients with chronic pyelonephritis and glomerulonephritis and a control group of IO healthy persons were examined during a free from medicamentous treatment period by a group of clearance tests in order to study the excretory system function and the degree of its affection in the earliest phases of the diseases studied. By means of the isotopic clearances of 169Yb-EDTA for determinations of the glomerular filtration, 131-I-hippuran for effective renal plasma circulation, the electrolytic clearances of Na, K, Ca, Cl and creatinine, the volume of the water excretion and the lithium clearance, the degree of the renal lesion was determined in every patient examined by the deviations from the normal values and the role of the different nephron sections as well. The results of the study revealed that the best tests for evaluation of the renal function in chronic renal diseases are the electrolyte clearances of Na, K, Ca, Cl, and in arterial hypertension--the lithium clearance.

Chronic Disease↗
PubMed1986

[Treatment with Pharmachim's Chlophazolin of hypertension and symptomatic hypertonia].

A total of 127 patients with arterial hypertension--64 with symptomatic and 63 with essential, were treated with chlophazolin "Pharmachim" at the Clinic of Therapy of Internal Diseases and Clinical Pharmacology for a period of one year. The drug was used alone in part of the patients and in the rest--in combination with other drugs. Satisfactory effect on the clinical symptoms and the level of blood pressure was attained in all patients treated and in only a small part of them diuretics and beta-blockers were necessary so as to attain better effect in coping with the arterial hypertension. In all patients the drug gave no toxic and allergic reactions, the most frequent adverse affects being the dryness of the mouth and sleepiness.

Adrenergic beta-Antagonists↗
PubMed1986

[Plasma levels and the antihypertensive effect of the preparation celiprolol].

The antihypertensive activity of the new cardioselective adrenergic blocker celiprolol in hypertonic disease, stage I-II, according to WHO as compared with the preparation acebutolol was assessed under the conditions of double blind study. Thirty patients with arterial hypertension were included in the study if after one week placebo period, met the criteria for inclusion. Blood samples from each patient, were collected for the determination of plasma concentrations of celiprolol before the beginning, by 2, 15 and 29 day of the treatment, 24 hour after the last intake and before the following intake. At the same time, each patient was subjected to complete physical and clinical-laboratory investigation. At a level of significance 99%, celiprolol and acebutolol reduced the systolic and diastolic arterial blood pressure to normal values by the end of the second and fourth week without any statistically significant difference between their antihypertensive activity. No significant difference was established between the values of blood pressure, recorded by the end of second and fourth week, in the patients treated with celiprolol and acebutolol. The analysis of the dependence of the reduced diastolic blood pressure on the value of plasma celiprolol concentration by the end of 14-day dose interval established a significant negative correlation (r = -0.737, p less than 0.1). The reduction of systolic blood pressure does not correlate with statistical significance, with the plasma levels of the preparation. The results from the study revealed that the preparations celiprolol and acebutolol have equivalent therapeutic effectiveness in the treatment of hypertonic disease, stage I-II according to WHO.(ABSTRACT TRUNCATED AT 250 WORDS)

Acebutolol↗
PubMed1985

[Clinical trial of drugs for treating urological infections--pipemidic acid].

A method was elaborated for clinical trial of pharmaceuticals for the treatment of infections of kidneys and urinary ducts. The main requirements are as follows: definitive diagnostic criteria for urological infection, monotherapy, systematic control for the drug intake, precisely formulated indices for assessment of the effect, strict follow-up of adverse and toxic effects. The effect was assessed according to a three-stage scale: very good, good and poor, consideration given not only to the clinical and laboratory indices but to adverse effects as well. Pipemidic acid was studied according to that model--the acid being a new chemotherapeutic, similar to nalidixic acid according to chemical composition and action. Out of all 29 patients treated, 19 were with very good effect, with good--6, and with poor--4. The adverse effects were negligible--one patient had light urticarial rash and pruritus.

Adult↗
PubMed1985

[Mycoplasma as the causative agent of kidney infections].

A total of 185 patients were investigated for M. hominis and mycoplasmal infection was established in 28 patients. In 2 of the patients mixed infection with E. coli was established and I with Staphylococcus aureus. Fifteen had pyelonephritis and 6--arterial hypertension, without positive data for pyelonephritis. The patients were treated with gentamycin and tetracycline according to the data of antibiograms of the isolated microorganisms. The criteria for admittance of the presence of mycoplasmal pyelonephritis are discussed.

Adolescent↗
PubMed1982

[Clinical trial of a Plantago major preparation in the treatment of chronic bronchitis].

Plantago major, according to literature data, has expectorant, antiphlogistic, pain-relieving effect. The experimental studies confirmed a spastic effect upon the smooth musculature of bronchi as well. Twenty five patients with chronic bronchitis were examined, with or without spastic character, with light and moderately severe deviations in ventilation indices. The treatment period was 25-30 days. A rapid effect on subjective complaints and objective findings was obtained in 80 per cent. Some indices of external respiration were favourably affected. The preparation is with a good tolerance, with no toxic effect on gastrointestinal tract, liver, kidneys, hemopoiesis.

Adult↗
PubMed1981

[Treanntment of duodenal ulcers and gastroduodenitis with a herbal combination of Symphitum officinalis and Calendula officinalis with and without antacids].

A total of 170 patients were treated--137 only with the herb combination (78 with duodenal ulcer and 59 with gastroduodenitis), 33--with the herb combination together with antacid (21 with duodenal ulcer and 12 with gastroduodenitis). As a result from the treatment, the spontaneous pains disappeared in 90 per cent of the patients--in the group with and in the group without antacid, the dyspeptic complaints faded in over 85 per cent but in the patients, treated with herbs and antacid the mentioned complaints disappeared several days earlier. The palpitation pains, in both groups, disappeared in more than 90 per cent of the patients within the same time. Gastric acidity, in both groups, showed a statistically insignificant tendency to decrease prior and post treatment. The gastroscopically control revealed that the ulcer niche, in both groups, was healed in almost the same percentage of the patients.

Adolescent↗
PubMed1981

[Use of an herbal combination with laxative action on duodenal peptic ulcer and gastroduodenitis patients with a concomitant obstipation syndrome].

Thirty two patients were treated--19 with duodenal ulcer and 19 with gastroduodenitis, all of them with concomitant obstipation syndrome. The patients were treated with a combination of Symphitum officinalis and Calendula officinales form the main disease. The obstipation syndrome was treated with a combination of Rhamus frangula, Citrus aurantium, Carum carvi. The laxative herb combination was effective in 100 per cent of the patients--daily defecation in 90.6 per cent and every second day in 9.4 per cent of the patients was attained. No effect on gastric mucosa was established as well as on the clinical effect of the main disease and on the percentage of the ulcer niche healing.

Adult↗
PubMed1981

[Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinaliss, Calendula officinalis and Foeniculum vulgare].

Twenty four patients with chronic non-specific colitis were treated with a herb combination. As a result from the treatment, the spontaneous and palpable pains along the large intestine disappeared in 95.83 per cent of the patients by the 15th day of their admission to the clinic. Defecation became daily in the patients with obstipation syndrome, but a combination of Rhamus frangula, Citrus aurantium, C. carvi was added to the herb combination already indicated. Defecation was normalized in patients with diarrhea syndrome. The pathological admixtures in feces disappeared.

Adult↗