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Biomedical subjects

A Końca

Publications and source records attributed to A Końca.

16 recordsLinked to original sources
PubMed1996

Premictional volume and contractility of the urinary bladder in patients with systemic sclerosis.

Ultrasonographic measurements of the urinary bladder in 21 women with systemic sclerosis (SSc) revealed abnormal volume of the bladder in about 65% of patients; 6/21 had a smaller bladder and 7/21 had a larger bladder than the controls. The volume of the remaining urine after miction was higher in 7 patients. Fibrosis of the bladder wall leading to a small rigid bladder and ureteral obstruction resulting in a large bladder with low contractility are suggested as phenomena involved in disturbed function of the urinary bladder in SSc patients. Patients with symptoms lasting more than 14 yrs. were found to have larger premictional volume of the bladder than those with short-lasting disease. No correlation between age, number of deliveries and bladder volume was found.

Adult↗
PubMed1993

[Volume of the functioning gallbladder and its emptying in patients with progressive systemic sclerosis].

UNLABELLED: The aim of the study was to measure the gallbladder volume (GV) and its emptying after meal stimulus in patients with progressive systemic sclerosis (PSS). 18 women with PSS, aged 49.8 +/- 9.5 yr, participated in the study. Control values were obtained from 30 healthy women aged 26.5 +/- 3.5 yr. The duration of PSS symptoms ranged from 2 to 25 yr. Subjects with gallstones or cholecystitis as well those receiving drugs affecting the gastroduodenal motor function were excluded from the study. GV was measured according to Dodds et all (1985) with the real-time sonographic apparatus (Sonoline SL Siemens, Germany), after an overnight fast and after a test meal. Measurements were repeated in 10 min intervals through a 40 min duration of the study. Similar volumes of fasted gallbladder were found in the PSS group and in the control group: 25.4 cm3, SEM 3.0 (PSS), vs. 20.9 cm3, SEM 1.6 (control), p > 0.05. There was not any correlation between the fasted GV and duration of the disease symptoms. The test meal evoked in both groups a similar trend of the decrease in the GV during 40 min and the increase in the ejection fraction at this time. Although the changes observed were statistically not significant (p > 0.05) there were small differences in the gallbladder ejection fraction in two patients, not exceeding 14% and 18%, and being apparently below of any individual value in the control group. CONCLUSION: the gallbladder motor function is very rarely disturbed in patients with PSS.

Female↗
PubMed1991

Effect of cold stress on gallbladder contractility in humans.

The effect of cold stress in the form of repeated hand immersion in ice cold water or repeated application to a hand of extremely cold - nitrogen gas, at a temperature of -180 degrees C (93 K), on the emptying of a meal-stimulated gallbladder was examined in seven healthy volunteers of both sexes. The control procedure consisted of repeated application to a hand of air at neutral temperatures (+35 degrees(-)+37 degrees C). Each subject underwent three examinations on separate days, the procedures being applied in random order. Gallbladder volume was measured by means of real-time ultrasonography. Measurements of volumes of the fasted gallbladder were also made on the three study days and gave similar values: 20.3 cm3, SEM 2.7 (control), 22.1 cm3, SEM 2.5 (cryotherapy), and 20.0 cm3, SEM 2.5 (cold immersion), F(2, 12) = 2.47, P greater than 0.1. A significant delaying effect of cold stress on postprandial gallbladder contractility was observed: F(2, 72) = 7.44, P less than 0.005, and F(2, 72) = 4.45, P less than 0.025 for gallbladder volume and ejection fraction, respectively. A significant difference was detected between the local application of cold gas and the control procedure (P less than 0.005) and local cryotherapy and the cold pressor test (P less than 0.05) in the case of the postprandial gallbladder volume, as well as between the local application of cold gas and the control procedure (P less than 0.025) for the ejection fraction.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

Effect of a synthetic prostaglandin E1 derivative, misoprostol, on fasted gallbladder volume and on meal-induced gallbladder emptying in man.

The effect of a single oral dose of 400 micrograms of misoprostol versus placebo on the fasted gallbladder volume and on meal-induced gallbladder emptying was assessed in 10 healthy subjects according to a double-blind study protocol. Gallbladder volumes were measured by means of real-time ultrasonography. The fasted gallbladder volume before drug administration was 18.9 +/- 1.1 cm3 on the placebo day, and 18.8 +/- 1.4 cm3 on the misoprostol day. No significant change in the gallbladder volume was observed 30 minutes after drug administration (18.3 +/- 1.3 cm3 placebo vs 20.2 +/- 1.8 cm3 misoprostol). The gallbladder volume 10 min after the test meal was significantly larger after misoprostol (16.9 +/- 1.7 cm3) than after placebo (12.8 +/- 1.6 cm3), p less than 0.02. However, the differences at subsequent time points (i.e. 20, 30, and 40 min after the test meal) proved to be insignificant. An insignificant effect of misoprostol on gallbladder emptying was revealed also by the analysis of the respective gallbladder ejection fractions. We conclude that misoprostol does not have any significant effect on fasted gallbladder volume or on meal-induced gallbladder emptying in humans.

Adult↗
PubMed1989

[Effect of calcitonin on gallbladder volume between food intake and on its emptying after meals in humans].

The effect of increasing i.v. doses of synthetic salmon calcitonin: 0.0044, 0.0088, 0.0175, and 0.0350 i.u..kg-1 min-1 versus placebo on the fasted gallbladder volume was assessed in 7 normal subjects according to a double-blind study protocol. In addition the action of calcitonin on meal-induced gallbladder emptying was examined. Gallbladder volumes were measured by means of real-time ultrasonography. An excellent day-to-day reproducibility of the fasted gallbladder volume was reflected by a coefficient of variation amounting to 12.2%, whereas the correlation coefficient between the fasted gallbladder volumes on day 1 and 2 amounted to r = 0.98, p less than 0.001. Calcitonin evoked a dose-dependent relaxation of the fasted gallbladder. A statistically significant increase of the fasted gallbladder volume was observed with 0.0175 (23.4 +/- 5.50 cm3 placebo vs 33.9 +/- 7.74 cm3 calcitonin, p less than 0.001) and 0.0350 (21.4 +/- 4.62 cm3 placebo vs 36.1 +/- 8.42 cm3 calcitonin, p less than 0.01) i.u..kg-1 min-1 calcitonin, where as mean increase of the gallbladder volume amounted to 32.1 and 46.5%, respectively. A significant delay of the gallbladder emptying after calcitonin was reflected by a decrease of the ejection fraction: 23.2 +/- 8.33% calcitonin vs 57.8 +/- 6.94% placebo (p less than 0.02) at 20 min, and 40.5 +/- 8.76% calcitonin vs 67.2 +/- 3.75% placebo (p less than 0.02) at 30 min after the test meal. Calcitonin is concluded to increase significantly the interdigestive gallbladder volume and to delay the meal-induced gallbladder emptying in humans.

Adult↗
PubMed1982

The influence of noise and vibration upon creatine kinase activity in blood serum.

The investigations comprised part of the workers employed in a factory of prefabricated concrete elements. The creatine kinase (CK) activity was determined before and after a day's work in the following groups of workers: I-exposed to noise and vibration exceeding the allowed norm, II- exposed to noise, performing the same hard physical work as group I and exposed to vibration not exceeding 79dB in particular octave bands, III- practising physical work a group I and II but in environment free from noise and vibration, and a control group of persons (C) not exposed to any of the tested factors (vibration, noise, work). The obtained results indicate that the determination of the CK activity may serve as a test of exposure to vibration and noise.

Adult↗
PubMed1982

Hypersensitivity to tobacco antigens in smokers and nonsmokers.

The examinations were carried out in 336 tobacco smokers, 91 persons who gave up smoking, 175 persons exposed to tobacco smoke indirectly and 112 persons who had nothing to do with tobacco smoke. Together 714 persons were examined. The examinations, which were carried out on the grounds of the clinic observations and the data obtained from interviews, aimed at the discovering of the causal nexus between the attacks of atopic bronchial asthma as well as the occurrence of acute urticaria and the exposure to tobacco smoke. All the patients underwent the dermic allergometric test with the extract from cigarette tobacco. The results of these examinations have not delivered any evidence concerning the allergenic reaction of the immediate type to tobacco smoke.

Allergens↗
PubMedDate not supplied

Effect of calcitonin on gall-bladder volume in man.

The effect of increasing intravenous doses of synthetic salmon calcitonin (0.0044, 0.0088, 0.0175, and 0.0350 iu/kg per min) versus placebo on the fasted gall-bladder volume was assessed in seven normal subjects according to a double-blind study protocol. In addition, the action of calcitonin on meal-induced gall-bladder emptying was examined. Gall-bladder volumes were measured by means of real-time ultrasonography. Calcitonin evoked a dose-dependent relaxation of the fasted gall-bladder. A statistically significant increase of the fasted gall-bladder volume was observed with 0.0175 (23.4 +/- 5.5 cm3 placebo versus 33.9 +/- 7.7 cm3 calcitonin, P less than 0.001) and 0.0350 (21.4 +/- 4.6 cm3 placebo versus 36.1 +/- 8.4 cm3 calcitonin, P less than 0.01) iu/kg per min calcitonin, whereas a mean increase of the gall-bladder volume amounted to 32.1% and 46.5%, respectively. A significant delay of the gall-bladder emptying after calcitonin was reflected by a decrease of the ejection fraction: 23.2 +/- 8.3% calcitonin versus 57.8 +/- 6.9% placebo (P less than 0.02) at 20 min, and 40.5 +/- 8.8% calcitonin versus 67.2 +/- 3.8% placebo (P less than 0.02) at 30 min after the test meal. Calcitonin is concluded to have a potent relaxing effect on the human gall-bladder.

Adult↗