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Biomedical subjects

A Kohút

Publications and source records attributed to A Kohút.

At least 55 records · Page 3Linked to original sources
PubMed1978

Age-dependent variations in the intensity of isoprenaline-induced myocardial lesions in rats.

Isoprenaline dosed 50 mg/kg was injected intraperitoneally into rats aged 42 days, 3 months, and 18 months. At intervals of 12, 18, 24, 48 hours and 5 days the degree of myocardial lesion was checked by the technetium-labeled oxytetracycline [99mTc-Sn-oxytetracycline] method. Three hours after its i. v. injection the myocardial radioactivity was measured in a control group and in the group treated with isoprenaline. Markedly higher radioactivity was found in animals given isoprenaline than in the controls. Besides, the degree of myocardial lesion considerably varied in dependence on the animals' age, being lowest in the 42-days-old and highest in the 18-months-old rats. In all age groups a biphasic alteration was observed, consisting of a phase of rapid decrease in radioactivity up to 24 hours, and a phase of slow decrease from the 24th hour till the 5th day after injection of isoprenaline. The authors consider the method using technetium-labeled oxytetracycline convenient for assessing the degree of myocardial lesion.

Age Factors↗
PubMed1978

Development of tolerance to morphine and pethidine in rats in dependence on age.

The development of tolerance to the analgesic effect of morphine (10 mg/kg.i.p.) and to pethidine 40 mg)/kg i.p.), given every 3 hours 13 times in succession or every 6 or 24 hours 7 times in succession, was studied in rats of different age groups (21 days, 42 days, 3 months and 18 months old). Pain threshold was determined by electric algic stimulation. The rate of tolerance development to the analgetic effect of morphine and pethidine decreased with age and changed only slightly with the frequency of application. In young animals (21 days old) the analgesic effect was very intensive after the first application of pethidine as well as morphine, after further applications the analgesic effect was reduced sharply until its complete disappearance. In animals aged 42 days and 3 months the analgesic effect was not so strong after the first applicaion but the decrease, too, was slower. In 18 months old animals the analgesic effect after the first dose was high and declined very moderately after further doses. It is assumed that the development of tolerance to the effect of strong analgesics is related to the rate of protein synthesis in the central nervous system.

Age Factors↗
PubMed1975

[Effect of ethanol on blood serotonin level].

The level of blood serotonin was determined in 11 healthy young men after administration of 1.0 g ethanol per 1 kg of body weight and in healthy dogs after administration of 2.0 g of ethanol per 1 kg of body weight. In men there was no substantial change in the blood level of serotonin. After administration of 2.0 g of ethanol per 1 kg of body weight in dogs, the blood level of serotonin was not found changed in the 60th minute of the experiment. After 4 hours after administration of ethanol already a significant decrease of the serotonin level appeared. After 24 hours following administration of ethanol there was a slight increase of the serotonin level as compared with the initial level. Slight changes of the serotonin level observed in the 30th and 60th minute of the experiment cannot explain the negative inotropic effect of ethanol.

Adult↗
PubMed1975

Changes in blood serotonin during hemodialysis.

Authors studied serotonin (5-hydroxytryptamin) in blood in patients with severe renal failure. Changes of serotonin in platelets and plasma in renal failure possibly play a part in clotting disorders of uremia. The authors found increased levels of serotonin in the patients, who suffered from acute and chronic renal failure. 15 patients were dialysed in regular dialysis treatment. Serotonin increased in blood after each dialysis. Platelets remained unchanged during hemodialysis. The authors discuss these new findings and correlate the above mentioned changes with electrolytes and some other laboratory findings.

Acute Kidney Injury↗
PubMed1975

Antiphlogistic action of phenylbutazone in normal and adrenalectomized rats of different ages relation to the 5-hydroxytryptamine blood concentration.

The authors have attempted to demonstrate the effect of bilateral adrenalectomy on carrageenin-induced oedema and on the antiphlogistic action of phenylbutazone in relation to the changes of blood 5-hydroxtryptamine (5-HT) in rats of different ages (21 days, 42 days, 3 months and 18 months old). It was found that the influence of adrenalectomy on the antiphlogistic action of phenylbutazone and on the blood 5-HT concentration is related to the age of rats. The lowest antiphlogistic action of phenylbutazone was found in 21-day-old rats and highest in the 18-month-old ones. In adrenalectomized 21- and 42-day-old rats the antiphlogistic action is decreased and fully suppressed in rats 3 and 18 months old. Adrenalectomy does not influenced basal values of blood 5-HT concentration. Blood 5-HT in adrenalectomized rats with inflammationadrenalectomized rats 42 days and 3 months old with inflammation after injection of phenylbutazone an increase of 5-HT was observed, but in 18-month-old animals in which antiphlogistic action is highest a decrease of 5-HT was observed.

Adrenalectomy↗