Biomedical subjects

A Kohonen

Publications and source records attributed to A Kohonen.

At least 19 recordsLinked to original sources

PubMed1987

Ceramic prostheses used as a columella.

Ceramic stems, their lateral end capped with a modelled ossicle, or ceramic prostheses manufactured with a cap-shaped head were used as a columella from the stapes footplate to the tympanic membrane or a fascia graft in 41 ears operated on during 1982-1985. Six ears had no membrane perforations and no severe disease of the tympanic mucosa. Twelve ears underwent primary operations for cholesteatoma and 23 ears had revision surgery. Good hearing improvement occurred in well-aerated ears while hearing in ears with extensive tympanic disease did not improve after surgery. No tissue reactions to the ceramic prosthesis were observed and no prosthesis was extruded. Ceramic can be regarded as an acceptable alternative to bone for columella grafts used in surgery for chronic middle ear disease when the stapes superstructure is missing.

Biocompatible Materials↗

PubMed1983

Penetration of trimethoprim--sulfadiazine into middle ear fluid in secretory otitis media.

Thirty-nine middle ear fluid samples from 23 patients with chronic secretory otitis media were studied. The patients received 3 doses of 3 mg of trimethoprim and 5 mg of sulfadiazine per kg body weight before tympanostomy, the last dose being given 80-270 min (mean 142 min) prior to operation. Mean trimethoprim concentrations were 1.62 micrograms/ml (range 0.8-3.5) and mean sulfadiazine concentrations 10.54 micrograms/ml (range 0-25.0). For most patients the levels exceeded the usual MIC-values for the two commonest pathogens; pneumococci and Haemophilus influenzae. Otitis media caused by beta-lactamase producing Haemophilus is an important indication for trimethoprim-sulfonamide therapy.

Adolescent↗

PubMed1976

Treatment of zygomatic fractures: internal wiring-antral-packing-reposition without fixation.

Fifty-two patients with zygomatic fractures were examined clinically and roentgenologically 1 to 4 years after treatment. Of these patients, 15 were treated with wiring fixation, 26 with antral packing using plastic tubing, and 11 with reduction only, without fixation. In the last group, the hospital stay was the shortest. These patients had also less complications and roentgenological changes when compared with the other groups. This was considered to be due to the fact that fractures not requiring fixation are initially less difficult than fractures requiring other treatment. At clinical examination, internal wiring fixation proved to be better than antral packing when hospital stay, restoration of the function of the infra-orbital nerve, the position of the eye, symmetry of the palpebral fissure and the final cosmetic results are considered. In the antral packing group, the result was better when jaw movements and occurrence of permanent diplopia were compared. The roentgenological examination revealed that the reduction results were more exact with internal fixation than with antral packing.

Adolescent↗

PubMed1975

Concentration of cephalexin in maxillary sinus mucosa and secretion.

Twenty patients hospitalized for unilateral or bilateral sinus surgery were given 500 mg or 15 mg/kg body weight of cephalexin by mouth two hours before operation. Samples of serum, sinus mucosa and secretion for cephalexin concentrations were taken during operation. There was a large variation in the mucosal and secretion concentrations and no definite correlation with serum levels. Drug levels effective against most gram-positive cocci were usually found in the mucosa. The mucosal concentrations were much larger than those in the secretion. There were no noteworthy differences between the patients with purulent infection and those in whom the infection was quiescent.

Adult↗

PubMed1972