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Biomedical subjects

A Komender

Publications and source records attributed to A Komender.

18 recordsLinked to original sources
PubMed2001

Preserved tissue allografts in reconstructive surgery.

Results of treatment with three various kinds of allografts: lyophilized bone, deep frozen bone and cartilage preserved in physiological solution, all of them radiation-sterilized are presented. We believe that this presentation may be helpful in estimating the tissue bank's allografts and in establishing indications and contraindications in the application of allografts in surgery.The 'indices of coincidence' were compared in a group of 1014 patients after bone (lyophilized and radiation-sterilized) transplantation. It seems that such a variable as 'rebuilding of graft' may be of prognostic value in analysing the results of treatment in this group.The application of frozen and radiation-sterilized allogenic bone grafts for reconstructions is also described. An analysis of the results of treatment in 1125 patients reveals that the use of preserved bone reduces the extent and duration of surgery. Almost total substitution of grafts may be seen in 3-8 months after surgery.Allogenic, preserved cartilage is often used in facial reconstructions of face. Human costal cartilage, preserved in 0.9% NaCl and radiation-sterilized, was used for reconstruction. The patients were examined 24-190 months after surgery (in several clinical units) and results were collected in a special questionnaire by the team that performed surgery. In an analysed group of 437 patients after cartilage transplantation, 42.2% were operated because of posttraumatical changes, 29.0% because of congenital malformations and in 16.7% non-specific inflammations were the cause of reconstructive operations. Malformations were located mainly in the nose (59%), the ear concha (16.5%) and 10.9% were mandible.The results of treatment were compared with ages of patients, diagnosis and the locations of the changes. Very good results were achieved in 33.5% of the patients, and satisfactory in 41.8% of the patients. However, in 19.9% of the patients the result of treatment was unsatisfactory. Correlation between some clinical and biological characteristics and the result of treatment is under discussion.

Journal Article↗
PubMed1997

Allogenic preserved costal cartilage in reconstructive surgery.

Allogenic, preserved cartilage is often used for reconstruction of face. This study was undertaken to analyze the effects of cartilage transplantation. In analyzed group of 437 patients after cartilage transplantation, 42.2% were operated because of posttraumatical changes, 29.0% because of congenital malformations. In 16.7% nonspecific inflammations were the cause of reconstructive operations. Malformations were mainly localised in nose 59%, ear concha 16.5% and mandible 10.9%. Human costal cartilage, preserved in 0.9% NaCl and radiation-sterilized was used for reconstruction. 24-190 months after surgery (in several clinical units) patients were examined and results were collected in special questionnaire by the team who performed surgery. The results of treatment were compared with age, diagnosis and localisation of changes. It was found that very good result of treatment was achieved in 33.5% of patients, in 41.8% result was satisfactory. In 19.9% of operated patients result of treatment was unsatisfactory. Correlation of some clinical and biological characteristics with the result of treatment is discussed.

Adolescent↗
PubMed1996

Bone banking for transplantation in orthopaedic reconstructions.

Results of orthopaedic reconstructions in 1014 patients with the use of preserved allogenic bone grafts are presented. The method of grafts preservation seems to be of significance in surgical applications; deep-freezing is more favorable in more comparison with lyophilization. The result of treatment after bone transplantation is dependent on numerous biological and clinical variables.

Bone Diseases↗
PubMed1991

Therapeutic effects of transplantation of lyophilized and radiation-sterilized, allogeneic bone.

Lyophilized radiation-sterilized bone graft operations were analyzed according to 27 variables in 1014 patients with two-year follow-up results. In 91.3% of patients, the result of treatment was "very good" (full-health restoration) or "satisfactory" (restoration with some small disorders). In 5.1%, the results were unsatisfactory. There was no clear association between the results of treatment and the patient's age. A definite correlation was found in preoperative diagnosis and end results. Better results were achieved in benign tumors and congenital malformations than in post-traumatic and degenerative conditions. Preferred anatomic host beds for transplantation were the coxa, arm, and vertebral column. Less satisfactory results were found in the leg and forearm. The number of good results of treatment declined with increasing duration of preoperative or chronic illness and with increasing postoperation time. Supplementary autogeneic bone did not seem to improve the end result. Concomitant disease was not always a contraindication for bone graft surgery. The significance of various traits in analysis of the final "result of treatment," "fitness for work," and "role of the graft" was evaluated with the aid of Pearson's indices of coincidence.

Adolescent↗
PubMed1987

Biological properties of preserved human dura mater grafts from different-age donors, tested in xenogenic system of transplantation.

Selected biological properties of human mater grafts obtained from different-age donors and preserved with two methods were tested in a xenogenic system of transplantation. The Regional Lymph Node Blastic Cell Reaction Test revealed relatively low immunogenicity of the material. Microscopic analysis showed that trypsinized grafts are rebuilt at a slower rate and evoke less local reaction than the ethanol-stabilized grafts. No influence of the donors' age on immunogenicity and local reaction after transplantation was observed.

Adult↗
PubMed1984

Some biological properties of preserved bovine fascia enriched with pulverized calf cartilage.

The immunogenicity of trypsinized and radiation-sterilized bovine fascia enriched with pulverized calf cartilage was tested by the regional lymph node blastic cell reaction. The influence of these grafts on the adjacent tissue and on regeneration processes was examined histologically. After transplantation into mice the grafts stimulated growth of new connective tissue and did not evoke an increase of the blastic cell reaction in the regional lymph nodes.

Animals↗
PubMed1981

Some biological properties of bovine trypsinized fascia xenografts.

Trypsinized, lyophilized and radiation-sterilized bovine fascia grafts were used for treatment of muscle and peritoneal defects induced in mice. The survival rate, general and surgery region condition of normal and pregnant mice after transplantation were investigated. The influence of grafts on the adjacent tissues and on regeneration processes was also examined. It is suggested that the grafts prepared by this new method, owing to their good tolerance and long resorption time, could be used in a human clinic.

Abdominal Muscles↗
PubMed1978

Immunogenicity of fresh and preserved cortical and cancellous allogeneic bone grafts as tested by modified migration inhibition test in mice.

Mice were grafted with allogeneic compact and cancellous bone. The bone used was fresh and preserved by either lyophilization or deep freezing. Preserved grafts were radiosterilized by a dose of 3.3 MRads. The immunization of recipients was assessed by a modified migration inhibition test based on migration of cells from three-dimensional clot culture. Both preservation methods seem to change bone immunogenicity and enhancement of migration instead of inhibition occurring in the case of fresh bone was noted.

Animals↗